Cell & Tissue Imaging Platform

The Cell and Tissue Imaging Platform (PICT) provides services, training and technological innovation in cellular imaging to academic and private scientific communities, in life science and health.

The platform is labelled “Infrastructure in Biology, Health and Agronomy” (IBiSA) and is a member of the France-BioImaging & Euro-Bioimaging infrastructures.

Our expertise covers multi-scale imaging from the molecule to the organism in the field of cancer research. The imaging center is composed of 3 poles: photonic microscopy, electron microscopy & CryoEM and high-content screening (HCS, Biophenics).

PICT_intro

Mission

  • Provide state-of-the-art technologies and expertise in photonic, electron & CryoEM microscopy, HCS (Biophenics) and image analysis,
  • Provide training, assistance and advice to users,
  • Carry out technical, methodological and software developments,
  • Collaborate on science and technology projects,
  • Participate in the dissemination of knowledge (training courses, congresses, open lab, etc.) at national and international level.

The platform is open to all researchers, both internal and external to the Institut Curie.

 

Newsletter

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April 2020
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Dec 2019
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Sept 2019
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June 2019

 

 

 

 

 

 

A little about the facility history…

PICT-IBiSA at Institut Curie won official recognition as an operational platform in life sciences (“Cell Imaging” Platforms coordination RIO) in 2003. This recognition has been renewed by the labeling of the PICT by the GIS IBiSA (Infrastructure in biology, health and agronomy – https://www.ibisa.net/) in 2008. PICT-IBiSA is a member of the consortium France BioImaging (https://france-bioimaging.org/) since 2011.

Since 2007, in close collaboration with Nikon France, Nikon BV and other industrial partners, PICT-IBiSA also hosts and administers the Nikon Imaging Centre @ Institut Curie-CNRS (http://nimce.curie.fr/), one of three centers of this kind in Europe, one of the nine, worldwide.

 

Key publications

Year of publication 2019

Denis Krndija, Fatima El Marjou, Boris Guirao, Sophie Richon, Olivier Leroy, Yohanns Bellaiche, Edouard Hannezo, Danijela Matic Vignjevic. (2019 Aug 16)

Active cell migration is critical for steady-state epithelial turnover in the gut.

Science : 365(6454) : 705-710 : DOI : 10.1126/science.aau3429
Anna Guadall, Sylvie Cochet, Olivier Renaud, Yves Colin, Caroline Le Van Kim, Alexandre G de Brevern, Wassim El Nemer (2019 Aug 16)

Dimerization and phosphorylation of Lutheran/basal cell adhesion molecule are critical for its function in cell migration on laminin.

The Journal of biological chemistry : 14911-14921 : DOI : 10.1074/jbc.RA119.007521
Jamecna D, Polidori DJ, Mesmin B, Dezi M, Lévy D, Bigay J, Antonny B (2019 Mar 22)

An intrinsically disordered region in OSBP acts as an entropic barrier to control protein dynamics and orientation at membrane contact sites

Developmental cell * : * highlighted Trend in Cell Biology 2019 : DOI : 10.1016/j.devcel.2019.02.021
Beber A, Taveneau C, Nania M, Tsai FC, Di Cicco A, Bassereau P, Lévy D, Cabral JT, Isambert H, Mangenot S*, Bertin A* (2019 Jan 24)

Membrane reshaping by micrometric curvature sensitive septin filaments

Nature communications : DOI : 10.1038/s41467-019-08344-5

Year of publication 2018

Antoine Hocher, Myriam Ruault, Petra Kaferle, Marc Descrimes, Mickaël Garnier, Antonin Morillon, Angela Taddei (2018 Oct 26)

Expanding heterochromatin reveals discrete subtelomeric domains delimited by chromatin landscape transitions.

Genome research : DOI : gr.236554.118
Anna M Lilja, Veronica Rodilla, Mathilde Huyghe, Edouard Hannezo, Camille Landragin, Olivier Renaud, Olivier Leroy, Steffen Rulands, Benjamin D Simons, Silvia Fre (2018 May 23)

Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland.

Nature cell biology : DOI : 10.1038/s41556-018-0108-1
All publications