U830 – Genetics and Biology of Cancers

Teams in this unit study various aspects of tumour development. Two main strategies are being developed:

  • the direct study of human malignancies to better understand their physiopathological mechanisms,

  • the uses experimental models (cells or animals) to address specific aspects of oncogenesis.

A variety of genetic methods including microarray, genotyping and next-generation sequencing analyses are developed to characterise human tumours, as well as molecular biology, cell biology and transgenesis approaches to create and investigate models are being used.

The main research themes of the unit include:

  • The link between oncogenesis, stemness and cell differentiation, especially in neural and mesenchymal cell lineages, with the goal of establishing similarities and differences between the biology of the tumour cells and their corresponding normal cells,
  • The genetic alterations in cancer cells, in particular the mechanisms of genetic instability that may be a cause or a consequence of tumour development,
  • The role of oxidative stress in angiogenesis, cell aging and tumour development,
  • The changes in intracellular traffic and in the cytoskeleton that are associated with malignant transformation.

Key publications

Year of publication 2020

Sebastian Müller, Fabien Sindikubwabo , Tatiana Cañeque, Anne Lafon, Antoine Versini, Bérangère Lombard, Damarys Loew, Ting-Di Wu, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Adeline Durand, Céline Vallot, Sylvain Baulande, Nicolas Servant, Raphaël Rodriguez (2020 Oct 1)

CD44 regulates epigenetic plasticity by mediating iron endocytosis

Nature Chemistry : 12 : 929-938 : DOI : 10.1038/s41557-020-0513-5

Year of publication 2018

Alculumbre SG, Saint-André V, Di Domizio J, Vargas P, Sirven P, Bost P, Maurin M, Maiuri P, Wery M, Roman MS, Savey L, Touzot M, Terrier B, Saadoun D, Conrad C, Gilliet M, Morillon A, Soumelis V (2018 Jan 1)

Diversification of human plasmacytoid predendritic cells in response to a single stimulus

Nature Immunology : 19(1) : 63-75 : DOI : 10.1038/s41590-017-0012-z

Year of publication 2015

Cristina Ghirelli, Fabien Reyal, Marine Jeanmougin, Raphaël Zollinger, Philémon Sirven, Paula Michea, Christophe Caux, Nathalie Bendriss-Vermare, Marie-Hélène Donnadieu, Martial Caly, Virginie Fourchotte, Anne Vincent-Salomon, Brigitte Sigal-Zafrani, Xavier Sastre-Garau, Vassili Soumelis (2015 May 16)

Breast Cancer Cell-Derived GM-CSF Licenses Regulatory Th2 Induction by Plasmacytoid Predendritic Cells in Aggressive Disease Subtypes.

Cancer research : 2775-87 : DOI : 10.1158/0008-5472.CAN-14-2386
Antonio Cappuccio, Raphaël Zollinger, Mirjam Schenk, Aleksandra Walczak, Nicolas Servant, Emmanuel Barillot, Philippe Hupé, Robert L Modlin, Vassili Soumelis (2015 Apr 21)

Combinatorial code governing cellular responses to complex stimuli.

Nature communications : 6847 : DOI : 10.1038/ncomms7847

Year of publication 2014

Maxime Touzot, Maximilien Grandclaudon, Antonio Cappuccio, Takeshi Satoh, Carolina Martinez-Cingolani, Nicolas Servant, Nicolas Manel, Vassili Soumelis (2014 May 29)

Combinatorial flexibility of cytokine function during human T helper cell differentiation.

Nature communications : 3987 : DOI : 10.1038/ncomms4987