immunotherapy Archives - Centre de recherche de l'Institut Curie

Translational Immunotherapy

Cancer immunotherapy can be viewed as “The Breakthrough of 2013”, switching cancer treatment from targeting the tumor to targeting the immune system. The blockade of immune checkpoints with antibodies (Ab) anti-CTLA-4, anti-PD1 and anti-PD-L1, has given impressive clinical results and manageable safety profiles. As reports of therapeutic efficacy with checkpoint inhibitors extend from metastatic melanoma, […]

Endocytic Trafficking and Intracellular Delivery

Amongst the major classes of biological macromolecules, carbohydrates remain the least well understood when it comes to molecular mechanisms of function. In the Endocytic Trafficking and Intracellular Delivery team, we have formulated the hypothesis that glycan-binding proteins (lectins) from pathogens (Shiga and cholera toxins, polyoma viruses such as SV40, norovirus) or cells (galectins) acquire curvature-active […]

Extracellular vesicles, immune responses and cancer

Cells release in their environment membrane-enclosed vesicles collectively called “Extracellular Vesicles” (EVs), which are thought to act as intercellular messengers. Exosomes are a type of EV formed inside endocytic compartments, the multivesicular bodies (MVBs) and secreted in vitro upon fusion of these MVBs with the plasma membrane. Other EVs, called microvesicles or ectosomes, are released […]