DNA repair Archives - Centre de recherche de l'Institut Curie

DRUM Team (DNA Repair and Uveal Melanoma)

Our team DNA Repair and Uveal Melanoma (D.R.U.M.) is mainly interested (i) in genomic instabilities in breast/ovarian cancers and uveal melanoma and (ii) in genetics and genomics of uveal melanoma, using innovative bioinformatics and data mining approaches. 1- Genomic characterization of breast and ovarian carcinoma. Deleterious germline mutations of the two major susceptibility genes BRCA1 […]

Alternative DNA repair in cancer

Our goal is to understand DNA repair mechanisms that are essential for the survival of cancer cells. Unraveling the function and structure of these mechanisms will facilitate the identification of new targets for the tailored treatment of cancer. DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genomic integrity. Failure to repair a DSB can […]

DNA Repair, radiations and innovative cancer therapies

Our team develop new antitumoral therapies associated to radio- and/or chemo-therapy to fight cancer resistance to treatment while limiting adverse effects. New small molecules named DBAit that inhibit major DNA Repair pathways During these last years we have: Analyzed the mechanism of action of DBait (short double-stranded DNA mimicking double-strand break). Developed derived Dbait molecules […]

Genome Instability and Cancer Predisposition

We are interested in DNA repair and its link to tumorigenesis. In particular, we study BRCA2, a tumor suppressor involved in DNA repair by Homologous Recombination. Mutations in this gene cause susceptibility to breast and ovarian cancer. Homologous Recombination In humans, the central player of the HR process is RAD51; it catalyzes the homology search […]