Maintenance of Transcriptional Repression by Polycomb Proteins

Chromatin structure is defined by several parameters such as combination of histone post-translational marks, nucleosome occupancy, DNA methylation or incorporation of histone variants. Chromatin structure contributes to the epigenetic regulation of gene expression, DNA replication or DNA repair.   The polycomb machinery maintains gene silencing throughout development. Consequently, interfering with its function alters various biological […]

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