Molecular Signaling, Epithelium-to-Mesenchyme transition, and Cell Motility in Embryogenesis

During embryogenesis, the epithelial-to-mesenchymal transition (EMT) is an essential morphogenetic process allowing epithelial cells to become separate migratory cells. This process is also activated when epithelial tumours develop metastases. In both cases, common gene activities such as Snail1 or Snail2 gene activation are involved. While the molecular mechanisms of Snail-induced EMT begin to be elucidated […]

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