cell division Archives - Centre de recherche de l'Institut Curie

Replication program and genome instability

DNA replication must adapt to changes in chromatin organization associated with cell differentiation and development, whose deregulation can challenge genome stability and leads to mutations, cancer and many other genetic diseases. However, despite intensive studies, the mechanisms that coordinate where and when replication initiates in the human genome remain poorly known. Our team focuses on […]

Cytoskeletal Architecture and Cell Morphogenesis

Our team explores how the cytoskeleton is organized, how it controls the establishment of functional membrane domains devoted to polarized cell growth or cell division, and how it is remodeled at mitotic entry for the assembly of the mitotic spindle and contractile ring, two complex molecular machines promoting chromosome segregation and cytokinesis. Most our studies […]

Systems Biology of Cell Polarity and Cell Division

Our latest publication in Cell: Link to the article Our latest publication in Science: The nucleus acts as a ruler tailoring cell responses to spatial constraints Science 16 Oct 2020: Vol. 370, Issue 6514 Our team studies different processes happening in the cell: cell migration, cell volume/mass […]

Biology of centrosomes and genetic instability

Known as the main microtubule organizing center of animal cells (MTOCs), the centrosome participates in the organization of the microtubule network within the cell. It is formed of two centrioles surrounded by a structured matrix of proteins called the pericentriolar material (PCM). While the centrioles are involved in the recruitment of the proteins that form […]

Controlling Microtubule Dynamics and Function with the tubulin code

Highlights Tubulin polyglutamylation induces neurodegeneration Tubulin glycylation coordinates sperm swimming Microtubules, key elements of the cytoskeleton, are involved in a large number of functions in eukaryotic cells. They assemble from a protein dimer of a- and b-tubulin, two highly similar and conserved proteins. Tubulins are subject to a large variety of posttranslational modifications (Fig. 1), which […]