breast cancer Archives - Centre de recherche de l'Institut Curie

DRUM Team (DNA Repair and Uveal Melanoma)

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Dynamics of epigenetic plasticity in cancer

Considerable data have been accumulated across the past decades on the role of mutations in cancer. However, while a number of genetic mechanisms driving tumor progression or resistance processes has been discovered, in many cases genetic mechanisms driving these processes cannot be found, raising the possibility of non-genetic plasticity or rare cell variability. Hence, besides […]

Residual Tumor and Response to Treatment

Fabien Reyal followed a dual program and graduated both as a surgeon and as a scientist. After training in gynecological surgery as a resident in Paris between 1995 and 2002, he became a senior surgeon in 2008 in Institut Curie (Paris) and is now mainly involved in breast cancer, plastic and reconstructive surgery. He has […]

Molecular Oncology

Our goal is to identify genetic and epigenetic events involved in tumor progression and new therapeutic targets. We focus on two carcinomas, bladder and breast cancer, and on retinoblastoma, a pediatric cancer of the retina. We use bioinformatics, based on large-scale transcriptomic, genomic and sequencing data, to identify genes and pathways potentially involved in tumor […]

Molecular Mechanisms of Mammary Gland Development

Our aim is to characterize the molecular mechanisms controlling the functions of stem and progenitor cells residing in mammary epithelial bilayer (Fig. 1) and analyze the contribution of these cells to tumorigenesis. Characterisation of mammary stem and progenitor cells In cooperation with John Stingl (Cambridge University, UK) we have demonstrated that mammary myoepithelial cells possess […]

Membrane and Cytoskeleton Dynamics

In breast cancer, transition of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) is associated with increased metastatic risk and drop in survival rate. The invasive switch of breast cancer requires tumor cells to cross the basement membrane (BM), a specialized extracellular matrix (ECM) that separates epithelial cells from the stroma. Following BM […]

Genetic Epidemiology of Cancer

The main aim of the U900 Cancer Epidemiology team is to study the genetic factors likely to play a part in the etiology of cancer. Taking into account all known (or expected) risk factors, we examine the interactions between these factors, aided by advances in the techniques of molecular genetics. These studies are of increasing […]

Diversity and Plasticity of Childhood Tumors (DePiCT)

Childhood cancers represent the second cause of death in children in developed countries. Most of these tumours develop from embryonal tissues and constitute, at the difference of adult tumours, accidents of development rather than of tissue renewal or aging. Other differences with adult cancers include the limited exposure of children to environmental mutagenic factors and […]

Homologous Recombination and Cancer

We are interested in DNA repair and its link to tumorigenesis. In particular, we study BRCA2, a tumor suppressor involved in DNA repair by Homologous Recombination. Mutations in this gene cause susceptibility to breast and ovarian cancer. Homologous Recombination In humans, the central player of the HR process is RAD51; it catalyzes the homology search […]