Cryo-electron microscopy and cryo-tomography of biomimetic systems/PICT IBISA

Within the PICT and in collaboration, we also analyse different biomimetic systems by cryo-electron microscopy, cryo-tomography, single particle analysis in negative staining.


From left to right: exosomes (van Niel, Cell Reports 2014), Nanoparticles (Yang, Macromolecules 2010), Gold Nanorods (Boglioti, J. Coll. Res. 2011), Polymersomes (Jia, Soft Matter, 2011)

Related publications:

Jia, L., Cui, D., Bignon, J., Di Cicco, A., Wdzieczak-Bakala, J., Liu, J., and Li, M.H. (2014). Reduction-responsive cholesterol-based block copolymer vesicles for drug delivery. Biomacromolecules 15, 2206-2217.

Hocine, S., Cui, D., Rager, M.N., Di Cicco, A., Liu, J.M., Wdzieczak-Bakala, J., Brulet, A., and Li, M.H. (2013). Polymersomes with PEG corona: structural changes and controlled release induced by temperature variation. Langmuir 29, 1356-1369.

Bogliotti N, Oberleitner B, Di-Cicco A, Schmidt F, Florent JC, Semetey V. Optimizing the formation of biocompatible gold nanorods for cancer research: functionalization, stabilization and purification. J Colloid Interface Sci. 2011 May 1;357(1):75-81

Yang, H., Jia, L., Wang, Z., Di Cicco, A., Lévy, D., and Keller, P. (2011) Novel photolabile diblock copolymers bearing truxillic acid derivative, Macromolecules 44, 159-165.

Jia, L., Lévy, D., Durand, D., Impéror, M., Cao, A., and Li, M. H. (2011) Smectic Polymer Micellar Aggregates with Temperature-Controlled Morphologies, Soft Matter 7, 7395 – 7403.

Yang, H., Jia, L., Zhu, C., Di Cicco, A., Lévy, D., Albouy, P. A., Li, M., and Keller, P. (2010) Amphiphilic Poly(Ethylene Oxide)-block-Poly(Butadiene-graft-Liquid Crystal) Copolymers: Synthesis via Thiol-Ene Click Chemistry and Self-Assembly in Water, Macromolecules 43 10442-10451.

Jia, L., Cao, A., Lévy, D., Xu, B., Albouy, P. A., Xing, X., Bowick, M. J., and M.H.Li. (2009) Smectic polymers vesicles. , Soft Matter 5, 3446-3451.

Mabrouk, E., Cuvellier, D., Pontani, L. L., Xu, B., Lévy, D., Keller, P., Brochard-Wyart, F., Nassoy, P., and M.H.Li. (2009) Formation and material properties of giant liquid crystal polymersomes., Soft Matter 5, 1870-1878.

Xu, B., Piñol, R., Nono-Djamen, M., Pensec, S., Keller, P., Albouy, P. A., Lévy, D., and Li , M. H. (2009) Self-assembly of liquid crystal block copolymer PEG-b-smectic polymer in pure state and in dilute aqueous solution., Faraday Discussion 143, 235-250.

Piñol, R., Jia L., Gubellini, F., Lévy, D., Albouy, P. A., Keller, P., .A., C., and Li, M. H. (2007) Self-Assembly of PEG-b-Liquid Crystal Polymer: The Role of Smectic Order in the Formation of Nanofibers. , Macromolecules 40, 5625-5627.

Yang, J., Pinol, R., Gubellini, F., Lévy, D., Albouy, P. A., Keller, P., and Li, M. H. (2006) Formation of polymer vesicles by liquid crystal amphiphilic block copolymers, Langmuir 22, 7907-7911.

Yang, J., Lévy, D., Deng, W., Keller, P., and Li, M. H. (2005) Polymer vesicles formed by amphiphilic diblock copolymers containing a thermotropic liquid crystalline polymer block, Chem Commun (Camb), 4345-4347.