Light-based Observation and Control of Cellular Organization (LOCCO)

Team Publications

Publications since 2012:

  1. El Beheiry, S. Doutreligne, C. Caporal, C. Ostertag, M. Dahan, J.B. Masson. “Virtual Reality: Beyond Visualization”. Journal of Molecular Biology (2019)
  2. de Beco S., Vaidziulyte K., Manzi J., Dalier F., Di Frederico F., Cornilleau G., Dahan M., Coppey M. Optogenetic dissection of Rac1 and Cdc42 gradient shaping. Nature Communication (2018)
  3. Etoc F., Balloul E., Vicario C., Normanno D., Liße D., Sittner A., Piehler J., Dahan M., Coppey M. “Non-specific interactions govern cytosolic diffusion of nano-sized objects in mammalian cells”. Nature Materials (2018).
  4. Lucas T., Tran H., Angelica Perez Romero C., Guillou A., Fradin C., Coppey M., Walczak A., Dostatni N. 3 minutes to precisely measure morphogen concentration. PLOS Genetics (2018)
  5. Tran H., Desponds J., Angelica Perez Romero C., Coppey M., Fradin C., Dostatni N., Walczak A. Precision in a rush: trade-offs between positioning and steepness of the hunchback expression pattern. PLOS Computational Biology (2018)
  6. Zago G., Veith I., Singh M., Fuhrmann L, De Beco S., Remorino A., Takaoka S., Palmeri M., Berger F., Brandon N., El Marjou A., Vincent-Salomon A., Camonis J., Coppey M., Parrini MC. RalB directly triggers invasion downstream Ras by mobilizing the Wave complex. Elife (2018)
  7. Amanda Remorino, Simon De Beco, Fanny Cayrac, Fahima Di Federico, Gaetan Cornilleau, Alexis Gautreau, Maria Carla Parrini, Jean-Baptiste Masson, Maxime Dahan, Mathieu Coppey, « Gradients of Rac1 nanoclusters support spatial patterns of Rac1 signaling » (2017 Cell Reports)
  8. Monzel, C. Vicario, J. Piehler, M. Coppey, M. Dahan, « Magnetic Control of Cellular Processes using Biofunctional Nanoparticles » (2017 Chemical Science)
  9. Lisse, C. Monzel, C. Vicario, I. Maurin, J. Manzi, M. Coppey, J. Piehler, and M. Dahan, « Engineered Ferritin for Magnetogenetic Manipulation of Proteins and Organelles Inside Living Cells» (2017 Advanced Materials)
  10. Hajj, B., Oudjedi, L., Fiche, J.B., Dahan, M.*, and Nollmann, M.* (2017). Optimizing the design of binary diffraction gratings for multicolor multifocus microscopy. (2017 Scientific Reports).
  11. Hajj, B.*, El Beheiry, M.*, and Dahan, M. (2016). PSF engineering in multifocus microscopy for increased depth volumetric imaging. Biomedical optics express 7, 726-731.
  12. Ferraro, T., Esposito, E., Mancini, L., Ng, S., Lucas, T., Coppey, M., Dostatni, N., Walczak, A.M., Levine, M., and Lagha, M. (2016). Transcriptional Memory in the Drosophila Embryo. Current biology : CB 26, 212-218.
  13. El Beheiry, M., Turkcan, S., Richly, M.U., Triller, A., Alexandrou, A., Dahan, M., and Masson, J.B. (2016). A Primer on the Bayesian Approach to High-Density Single-Molecule Trajectories Analysis. Biophysical journal 110, 1209-1215.
  14. Desponds, J., Tran, H., Ferraro, T., Lucas, T., Perez Romero, C., Guillou, A., Fradin, C., Coppey, M., Dostatni, N., and Walczak, A.M. (2016). Precision of Readout at the hunchback Gene: Analyzing Short Transcription Time Traces in Living Fly Embryos. PLoS computational biology 12, e1005256.
  15. Delepine, C., Meziane, H., Nectoux, J., Opitz, M., Smith, A.B., Ballatore, C., Saillour, Y., Bennaceur-Griscelli, A., Chang, Q., Williams, E.C., et al. (2016). Altered microtubule dynamics and vesicular transport in mouse and human MeCP2-deficient astrocytes. Human molecular genetics 25, 146-157.
  16. Coulon, A., and Larson, D.R. (2016). Fluctuation Analysis: Dissecting Transcriptional Kinetics with Signal Theory. Methods in enzymology 572, 159-191.
  17. Abrahamsson, S., Ilic, R., Wisniewski, J., Mehl, B., Yu, L., Chen, L., Davanco, M., Oudjedi, L., Fiche, J.B., Hajj, B., et al. (2016). Multifocus microscopy with precise color multi-phase diffractive optics applied in functional neuronal imaging. Biomedical optics express 7, 855-869.
  18. Valon, L., Etoc, F., Remorino, A., di Pietro, F., Morin, X., Dahan, M., and Coppey, M. (2015). Predictive Spatiotemporal Manipulation of Signaling Perturbations Using Optogenetics. Biophysical journal 109, 1785-1797.
  19. Normanno, D., Boudarene, L., Dugast-Darzacq, C., Chen, J.J., Richter, C., Proux, F., Benichou, O., Voituriez, R., Darzacq, X., and Dahan, M. (2015). Probing the target search of DNA-binding proteins in mammalian cells using TetR as model searcher. Nat Commun 6.
  20. Maiuri, P., Rupprecht, J.F., Wieser, S., Ruprecht, V., Benichou, O., Carpi, N., Coppey, M., De Beco, S., Gov, N., Heisenberg, C.P., et al. (2015). Actin Flows Mediate a Universal Coupling between Cell Speed and Cell Persistence. Cell 161, 374-386.
  21. Knight, S.C., Xie, L.Q., Deng, W.L., Guglielmi, B., Witkowsky, L.B., Bosanac, L., Zhang, E.T., El Beheiry, M., Masson, J.B., Dahan, M., et al. (2015). Dynamics of CRISPR-Cas9 genome interrogation in living cells. Science 350, 823-826.
  22. Etoc, F., Vicario, C., Lisse, D., Siaugue, J.M., Piehler, J., Coppey, M., and Dahan, M. (2015). Magnetogenetic Control of Protein Gradients Inside Living Cells with High Spatial and Temporal Resolution. Nano Lett 15, 3487-3494.
  23. El Beheiry, M., Dahan, M., and Masson, J.B. (2015). InferenceMAP: mapping of single-molecule dynamics with Bayesian inference. Nat Methods 12, 594-595.
  24. Dupin, I., Lokmane, L., Dahan, M., Garel, S., and Studer, V. (2015). Subrepellent doses of Slit1 promote Netrin-1 chemotactic responses in subsets of axons. Neural development 10, 5.
  25. Caccianini, L., Normanno, D., Izeddin, I., and Dahan, M. (2015). Single molecule study of non-specific binding kinetics of LacI in mammalian cells. Faraday discussions 184, 393-400.
  26. Wisniewski, J., Hajj, B., Chen, J.J., Mizuguchi, G., Xiao, H., Wei, D., Dahan, M., and Wu, C. (2014). Imaging the fate of histone Cse4 reveals de novo replacement in S phase and subsequent stable residence at centromeres. eLife 3.
  27. Recamier, V., Izeddin, I., Bosanac, L., Dahan, M., Proux, F., and Darzacq, X. (2014). Single cell correlation fractal dimension of chromatin: a framework to interpret 3D single molecule super-resolution. Nucleus 5, 75-84.
  28. Masson, J.B., Dionne, P., Salvatico, C., Renner, M., Specht, C.G., Triller, A., and Dahan, M. (2014). Mapping the Energy and Diffusion Landscapes of Membrane Proteins at the Cell Surface Using High-Density Single-Molecule Imaging and Bayesian Inference: Application to the Multiscale Dynamics of Glycine Receptors in the Neuronal Membrane. Biophysical journal 106, 74-83.
  29. Izeddin, I., Recamier, V., Bosanac, L., Cisse, II, Boudarene, L., Dugast-Darzacq, C., Proux, F., Benichou, O., Voituriez, R., Bensaude, O., et al. (2014). Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus. eLife 3.
  30. Hajj, B., Wisniewski, J., El Beheiry, M., Chen, J.J., Revyakin, A., Wu, C., and Dahan, M. (2014). Whole-cell, multicolor superresolution imaging using volumetric multifocus microscopy. Proceedings of the National Academy of Sciences of the United States of America 111, 17480-17485.
  31. Chen, O., Riedemann, L., Etoc, F., Herrmann, H., Coppey, M., Barch, M., Farrar, C.T., Zhao, J., Bruns, O.T., Wei, H., et al. (2014). Magneto-fluorescent core-shell supernanoparticles. Nat Commun 5.
  32. Chen, J.J., Zhang, Z.J., Li, L., Chen, B.C., Revyakin, A., Hajj, B., Legant, W., Dahan, M., Lionnet, T., Betzig, E., et al. (2014). Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells. Cell 156, 1274-1285.
  33. Specht, C.G., Izeddin, I., Rodriguez, P.C., El Beheiry, M., Rostaing, P., Darzacq, X., Dahan, M., and Triller, A. (2013). Quantitative nanoscopy of inhibitory synapses: counting gephyrin molecules and receptor binding sites. Neuron 79, 308-321.
  34. Lucas, T., Ferraro, T., Roelens, B., Chanes, J.D., Walczak, A.M., Coppey, M., and Dostatni, N. (2013). Live Imaging of Bicoid-Dependent Transcription in Drosophila Embryos. Current Biology 23, 2135-2139.
  35. Etoc, F., Lisse, D., Bellaiche, Y., Piehler, J., Coppey, M., and Dahan, M. (2013). Subcellular control of Rac-GTPase signalling by magnetogenetic manipulation inside living cells. Nature nanotechnology 8, 193-198.
  36. El Beheiry, M., and Dahan, M. (2013). ViSP: representing single-particle localizations in three dimensions. Nat Methods 10, 689-690.
  37. Cisse, I.I., Izeddin, I., Causse, S.Z., Boudarene, L., Senecal, A., Muresan, L., Dugast-Darzacq, C., Hajj, B., Dahan, M., and Darzacq, X. (2013). Real-Time Dynamics of RNA Polymerase II Clustering in Live Human Cells. Science 341, 664-667.
  38. Abrahamsson, S., Chen, J.J.*, Hajj, B.*, Stallinga, S., Katsov, A.Y., Wisniewski, J., Mizuguchi, G., Soule, P., Mueller, F., Darzacq, C.D., et al. (2013). Fast multicolor 3D imaging using aberration-corrected multifocus microscopy. Nat Methods 10, 60-U80.
  39. Studer, V., Bobin, J., Chahid, M., Mousavi, H.S., Candes, E., and Dahan, M. (2012). Compressive fluorescence microscopy for biological and hyperspectral imaging. Proceedings of the National Academy of Sciences of the United States of America 109, E1679-E1687.
  40. Morel, M., Shynkar, V., Galas, J.C., Dupin, I., Bouzigues, C., Studer, V., and Dahan, M. (2012). Amplification and Temporal Filtering during Gradient Sensing by Nerve Growth Cones Probed with a Microfluidic Assay. Biophysical journal 103, 1648-1656.
  41. Morel, M., Galas, J.C., Dahan, M., and Studer, V. (2012). Concentration landscape generators for shear free dynamic chemical stimulation. Lab on a chip 12, 1340-1346.
  42. Izeddin, I., El Beheiry, M., Andilla, J., Ciepielewski, D., Darzacq, X., and Dahan, M. (2012). PSF shaping using adaptive optics for three-dimensional single-molecule super-resolution imaging and tracking. Optics express 20, 4957-4967.
  43. Izeddin, I., Boulanger, J., Racine, V., Specht, C.G., Kechkar, A., Nair, D., Triller, A., Choquet, D., Dahan, M., and Sibarita, J.B. (2012). Wavelet analysis for single molecule localization microscopy. Optics express 20, 2081-2095.
  44. Bouthour, W., Leroy, F., Emmanuelli, C., Carnaud, M., Dahan, M., Poncer, J.C., and Levi, S. (2012). A Human Mutation in Gabrg2 Associated with Generalized Epilepsy Alters the Membrane Dynamics of GABA(A) Receptors. Cereb Cortex 22, 1542-1553.