Membranes and Cellular Functions

Team Members

Patricia Bassereau, PhD

Bassereau

Patricia Bassereau Research Officer CNRS Team Bassereau Team Leader Tel: Back to the list

Link to CV

Short CV

Patricia Bassereau is CNRS Directrice de Recherche at the Institut Curie in Paris where she is the leader of the group "Membranes and cellular functions". She obtained a short PhD and a PhD in Soft Matter at the University of Montpellier where she started her carrier on the structure of self-assembled surfactant-based systems. She spent one year as a visiting scientist at the IBM Almaden Center (San Jose, USA) on thin polymer films. She moved to the Institut Curie in 1993 to work on questions related to "Physics of the cell". She develops a multidisciplinary approach, largely based on synthetic biology and biomimetic systems, as well as quantitative mechanical and microscopy methods to understand the role of biological membranes and of their organization in cellular functions such as intracellular trafficking, endo/exocytosis or adhesion. Additionally, she studies in vitro and in cellulo the mechanics and the generation of cellular protrusions. In parallel, she contributes to a more comprehensive physical description of biomembranes by studying the consequences of non-equilibrium transmembrane transport of ions on membrane mechanics ("active membranes"), the relation between membrane proteins' shape and their diffusion or their lateral distribution on membranes.

Education
Master: Solid State Physics (1983),
PhD (1985), PhD (1990)
Clearance (1999)

Positions
GDPC-Montpellier (1983-1991)
IBM Almaden (USA) (1992)
Physical Chemistry Curie-Paris (1993-Present)

Research themes
Soft Condensed Matter (Surfactants in solution, polymers, membranes), Physics for Biology, Physics of bio-membranes

Current research
Intracellular traffic, non-equilibrium membranes, membrane nanotubes, membranes in transportation, mechanics of filopodia

 

 

 

 

 

Key publications

Year of publication 2019

Beber A, Taveneau C, Nania M, Tsai FC, Di Cicco A, Bassereau P, Lévy D, Cabral JT, Isambert H, Mangenot S*, Bertin A* (2019 Jan 24)

Membrane reshaping by micrometric curvature sensitive septin filaments

Nature communications : DOI : 10.1038/s41467-019-08344-5

Year of publication 2018

Feng-Ching Tsai*, Aurelie Bertin*, Hugo Bousquet, John Manzi, Yosuke Senju, Meng-Chen Tsai, Laura Picas, Stephanie Miserey-Lenkei, Pekka Lappalainen, Emmanuel Lemichez, Evelyne Coudrier*, Patricia Bassereau* (2018 Sep 30)

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner.

elife : 7 : e37262 : DOI : 10.7554/eLife.37262

Year of publication 2017

Mijo Simunovic, Jean-Baptiste Manneville, Henri-François Renard, Emma Evergren, Krishnan Raghunathan, Dhiraj Bhatia, Anne K. Kenworthy, Gregory A. Voth, Jacques Prost, Harvey T. McMahon, Ludger Johannes, Patricia Bassereau, Andrew Callan-Jones (2017 Jun 22)

Friction mediates scission of tubular membranes scaffolded by BAR proteins

CellCell : 170 : 172-184 : DOI : 10.1016/j.cell.2017.05.047
Garten M., Mosgaard L.D., Bornschlögl T., Dieudonné S., Bassereau P., Toombes G.E.S. (2017 Jan 1)

Whole-GUV patch-clamping

Proceedings of the National Academy of Sciences : 114 : 328-333 : DOI : 10.1073/pnas.1609142114

Year of publication 2016

Mijo Simunovic, Emma Evergren, Ivan Golushko, Coline Prévost, Henri-François Renard, Ludger Johannes, Harvey T McMahon, Vladimir Lorman, Gregory A Voth, Patricia Bassereau (2016 Oct 4)

How curvature-generating proteins build scaffolds on membrane nanotubes.

Proceedings of the National Academy of Sciences of the United States of America : 113 : DOI : 10.1073/pnas.1606943113

Year of publication 2015

Coline Prévost, Hongxia Zhao, John Manzi, Emmanuel Lemichez, Pekka Lappalainen, Andrew Callan-Jones, Patricia Bassereau (2015 Feb 26)

IRSp53 senses negative membrane curvature and phase separates along membrane tubules.

Nature communications : 8529 : DOI : 10.1038/ncomms9529

Year of publication 2014

Laura Picas, Julien Viaud, Kristine Schauer, Stefano Vanni, Karim Hnia, Vincent Fraisier, Aurélien Roux, Patricia Bassereau, Frédérique Gaits-Iacovoni, Bernard Payrastre, Jocelyn Laporte, Jean-Baptiste Manneville, Bruno Goud (2014 Dec 9)

BIN1/​M-Amphiphysin2 induces clustering of phosphoinositides to recruit its downstream partner dynamin

Nature Communications5 : DOI : 10.1038/ncomms6647
Laura Picas, Julien Viaud, Kristine Schauer, Stefano Vanni, Karim Hnia, Vincent Fraisier, Aurélien Roux, Patricia Bassereau, Frédérique Gaits-Iacovoni, Bernard Payrastre, Jocelyn Laporte, Jean-Baptiste Manneville, Bruno Goud (2014 May 19)

BIN1/M-Amphiphysin2 induces clustering of phosphoinositides to recruit its downstream partner dynamin.

Nature communications : 5647 : DOI : 10.1038/ncomms6647
Ayako Yamada, Alexandre Mamane, Jonathan Lee-Tin-Wah, Aurélie Di Cicco, Coline Prévost, Daniel Lévy, Jean-François Joanny, Evelyne Coudrier, Patricia Bassereau (2014 Apr 7)

Catch-bond behaviour facilitates membrane tubulation by non-processive myosin 1b.

Nature communications : 3624 : DOI : 10.1038/ncomms4624
François Quemeneur, Jon K Sigurdsson, Marianne Renner, Paul J Atzberger, Patricia Bassereau, David Lacoste (2014 Mar 24)

Shape matters in protein mobility within membranes.

Proceedings of the National Academy of Sciences of the United States of America : 5083-7 : DOI : 10.1073/pnas.1321054111
Sophie Aimon, Andrew Callan-Jones, Alice Berthaud, Mathieu Pinot, Gilman E S Toombes, Patricia Bassereau (2014 Jan 27)

Membrane shape modulates transmembrane protein distribution.

Developmental cell : 212-8 : DOI : 10.1016/j.devcel.2013.12.012

Year of publication 2013

Thomas Bornschlögl, Stéphane Romero, Christian L Vestergaard, Jean-François Joanny, Guy Tran Van Nhieu, Patricia Bassereau (2013 Nov 6)

Filopodial retraction force is generated by cortical actin dynamics and controlled by reversible tethering at the tip.

Proceedings of the National Academy of Sciences of the United States of America : 18928-33 : DOI : 10.1073/pnas.1316572110
Manuela Dezi, Aurelie Di Cicco, Patricia Bassereau, Daniel Lévy (2013 Apr 15)

Detergent-mediated incorporation of transmembrane proteins in giant unilamellar vesicles with controlled physiological contents.

Proceedings of the National Academy of Sciences of the United States of America : 7276-81 : DOI : 10.1073/pnas.1303857110

Year of publication 2007

Winfried Römer, Ludwig Berland, Valérie Chambon, Katharina Gaus, Barbara Windschiegl, Danièle Tenza, Mohamed R E Aly, Vincent Fraisier, Jean-Claude Florent, David Perrais, Christophe Lamaze, Graça Raposo, Claudia Steinem, Pierre Sens, Patricia Bassereau, Ludger Johannes (2007 Aug 15)

Shiga toxin induces tubular membrane invaginations for its uptake into cells.

Nature : 670-5