Lipid membranes exhibit non-trivial properties Especially at length scales much larger than molecular sizes. Purely molecular description of membranes is Not Sufficient to Accomplish Accomplish Accomplish Accomplish Accomplish accomplish achieve a quantitative understanding of Their function, and meso-scale concepts coming from soft matter and statistical physics are considers. In addition, cell membranes involve a wide number of proteins that may have some activity and are inserted or interact with membranes, which completely Call Call Call Call Call Call the exchange physical description.
Our general goal is to contribute to a more comprehensive understanding of biological membranes and of Their role in cells.
Model bio-membranes and cell membranes
Our group HAS Develops Multidisciplinary approach, Largely based on synthetic biology, biomimetic systems and quantitative measurements of Physics, To Understand the role of lipid membranes and associated proteins in essential cellular functions , such as:
- intracellular trafficking, endo / exocytosis, cell infection, transmembrane transportation of ions ( “active membrane”) and protein diffusion.
We also Investigate Were Both live cells and on in vitro systems the Mechanisms leading to filopodia formation and power generation by thesis cell structures.
We Develop different model membrane systems, in PARTICULARLY based on Giant Unilamellar Vesicles (GUV) and purified proteins (cytosolic or transmembrane). Our quantitative confocal microscopy experiments combined Generally, optical tweezers, micromanipulation, micropipette aspiration, as well as single particle tracking for diffusion measurements. Since Many projects address issues related to membrane deformation (curvature) and membrane mechanics, the group HAS Developed assays with membrane nanotubes pulled from GUVs gold from cells.
Our Approaches and issues are motivated by our close cooperation with cell biologists at the Institut Curie and outside, with Microbiologists and with Theoreticians .