UMR168 – Physico Chimie Curie Lab

Open internship positions are available on teams websites.

The goal of the unit is to uncover the role of physical laws in the architecture and functions of cellular systems. To this end, the teams follow cross-disciplinary approaches involving physics, chemistry and biology.

Studies cover a breadth of topics ranging from single molecules (molecular motors, DNA-protein interactions, membrane proteins) to cellular functions (cell adhesion, cell division, cell motility, intracellular transport) and the collective behaviour of cells in tissues and organisms (wound healing, morphogenesis). They include the use of many experimental systems going from isolated molecular assemblies and biomimetic systems to cellular and multicellular systems.

The approaches combine theoretical studies – including statistical physics of non-equilibrium systems – and a variety of experimental techniques such as optical and electron microscopy, as well as microfluidics and micropatterning, optogenetics, or mechanical micromanipulation using optical or magnetic tweezers.

Key publications

Year of publication 2016

A Bertin, E Nogales (2016 Jul 31)

Preparing recombinant yeast septins and their analysis by electron microscopy.

Methods in cell biology : 21-34 : DOI : 10.1016/bs.mcb.2016.03.010
Aurélie Bertin, Eva Nogales (2016 Jan 15)

Characterization of Septin Ultrastructure in Budding Yeast Using Electron Tomography.

Methods in molecular biology (Clifton, N.J.) : 113-23 : DOI : 10.1007/978-1-4939-3145-3_9

Year of publication 2015

Maria-Elena Fernandez-Sanchez, Thibaut Brunet, Jens-Christian Röper, Emmanuel Farge (2015 Sep 24)

Mechanotransduction’s impact on animal development, evolution, and tumorigenesis.

Annual review of cell and developmental biology : 373-97 : DOI : 10.1146/annurev-cellbio-102314-112441
Leïla Perié, Ken R Duffy, Lianne Kok, Rob J de Boer, Ton N Schumacher (2015 Jul 20)

The Branching Point in Erythro-Myeloid Differentiation.

Cell : 1655-62 : DOI : 10.1016/j.cell.2015.11.059
Param Priya Singh, Jatin Arora, Hervé Isambert (2015 Jul 17)

Identification of Ohnolog Genes Originating from Whole Genome Duplication in Early Vertebrates, Based on Synteny Comparison across Multiple Genomes.

PLoS computational biology : e1004394 : DOI : 10.1371/journal.pcbi.1004394
María Elena Fernández-Sánchez, Sandrine Barbier, Joanne Whitehead, Gaëlle Béalle, Aude Michel, Heldmuth Latorre-Ossa, Colette Rey, Laura Fouassier, Audrey Claperon, Laura Brullé, Elodie Girard, Nicolas Servant, Thomas Rio-Frio, Hélène Marie, Sylviane Lesieur, Chantal Housset, Jean-Luc Gennisson, Mickaël Tanter, Christine Ménager, Silvia Fre, Sylvie Robine, Emmanuel Farge (2015 Jul 2)

Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure.

Nature : 92-5 : DOI : 10.1038/nature14329