UMR168 – Physico-Chimie Curie Lab

Open internship positions are available on teams websites.

The goal of the unit is to uncover the role of physical laws in the architecture and functions of cellular systems. To this end, the teams follow cross-disciplinary approaches involving physics, chemistry and biology.

Studies cover a breadth of topics ranging from single molecules (molecular motors, DNA-protein interactions, membrane proteins) to cellular functions (cell adhesion, cell division, cell motility, intracellular transport) and the collective behaviour of cells in tissues and organisms (wound healing, morphogenesis). They include the use of many experimental systems going from isolated molecular assemblies and biomimetic systems to cellular and multicellular systems.

The approaches combine theoretical studies – including statistical physics of non-equilibrium systems – and a variety of experimental techniques such as optical and electron microscopy, as well as microfluidics and micropatterning, optogenetics, or mechanical micromanipulation using optical or magnetic tweezers.

Key publications

Year of publication 2019

Jamecna D, Polidori DJ, Mesmin B, Dezi M, Lévy D, Bigay J, Antonny B (2019 Mar 22)

An intrinsically disordered region in OSBP acts as an entropic barrier to control protein dynamics and orientation at membrane contact sites

Developmental cell : DOI : doi.org/10.1016/j.devcel.2019.02.021
Simon C*, Kusters R*, Caorsi V*, Allard A, Abou-Ghali M, Manzi J, Di Cicco A, Lévy D, Lenz M, Joanny J-F, Campillo C, Plastino J, Sens P*, Sykes C* (2019 Mar 18)

Actin dynamics drive cell-like membrane deformation

Nature Physics : DOI : 10.1038/s41567-019-0464-1
Beber A, Taveneau C, Nania M, Tsai FC, Di Cicco A, Bassereau P, Lévy D, Cabral JT, Isambert H, Mangenot S*, Bertin A* (2019 Jan 24)

Membrane reshaping by micrometric curvature sensitive septin filaments

Nature communications : DOI : 10.1038/s41467-019-08344-5

Year of publication 2018

Cáceres R, Bojanala N, Kelley LC, Dreier J, Manzi J, Di Federico F, Chi Q, Risler T, Testa I, Sherwood DR, Plastino J (2018 Nov 6)

Forces drive basement membrane invasion in Caenorhabditis elegans

Proceedings of the National Academy of Sciences USA : 115 : 11537-11542 : DOI : 10.1073/pnas.1808760115
Kutscher LM, Keil W, Shaham S (2018 Oct 22)

RAB-35 and ARF-6 GTPases Mediate Engulfment and Clearance Following Linker Cell-Type Death

Developmental Cell : 47 : 222-238 : DOI : 10.1016/j.devcel.2018.08.015
Vincent Nier, Grégoire Peyret, Joseph d'Alessandro, Shuji Ishihara, Benoit Ladoux, Philippe Marcq (2018 Oct 11)

Kalman Inversion Stress Microscopy.

Biophysical journal : DOI : S0006-3495(18)31065-8