UMR168 – Physico-Chimie Curie Lab

Open internship positions are available on teams websites.

The goal of the unit is to uncover the role of physical laws in the architecture and functions of cellular systems. To this end, the teams follow cross-disciplinary approaches involving physics, chemistry and biology.

Studies cover a breadth of topics ranging from single molecules (molecular motors, DNA-protein interactions, membrane proteins) to cellular functions (cell adhesion, cell division, cell motility, intracellular transport) and the collective behaviour of cells in tissues and organisms (wound healing, morphogenesis). They include the use of many experimental systems going from isolated molecular assemblies and biomimetic systems to cellular and multicellular systems.

The approaches combine theoretical studies – including statistical physics of non-equilibrium systems – and a variety of experimental techniques such as optical and electron microscopy, as well as microfluidics and micropatterning, optogenetics, or mechanical micromanipulation using optical or magnetic tweezers.

Key publications

Year of publication 2021

Vial Anthony, Taveneau Cyntia, Costa Luca , Chauvin Brieuc , Nasrallah Hussein , Godefroy Cédric, Dosset Patrice , Isambert Hervé , Ngo Kien Xuan, Mangenot Stéphanie , Levy Daniel , Bertin Aurélie* , Milhiet Pierre-Emmanuel * (2021 Jun 29)

Correlative AFM and fluorescence imaging demonstrate nanoscale membrane remodeling and ring-like and tubular structure formation by septins

Nanoscale : DOI : 10.1039/D1NR01978C
Eugenio de la Mora, Manuela Dezi, Aurélie Di Cicco, Joëlle Bigay, Romain Gautier, John Manzi, Joël Polidori, Daniel Castaño Díez, Bruno Mesmin, Bruno Antonny, Daniel Lévy. (2021 Jun 7)

Nanoscale architecture of a VAP-A-OSBP tethering complex at membrane contact sites

Nature Communications : DOI : 10.1038/s41467-021-23799-1
Stec Natalia, Doerfel Katja, Hills-Muckey Kelly, Ettorre Victoria, Ercan Sevinc, Keil Wolfgang, Hammell Christopher (2021 Feb 22)

An Epigenetic Priming Mechanism Mediated by Nutrient Sensing Regulates Transcriptional Output

Current Biology : 31 : 809-826.e6 : DOI : https://doi.org/10.1016/j.cub.2020.11.060

Year of publication 2020

R G Alonso, M Tobin, P Martin, A J Hudspeth (2020 Nov 17)

Fast recovery of disrupted tip links induced by mechanical displacement of hair bundles.

Proceedings of the National Academy of Sciences of the United States of America : 30722-30727 : DOI : 10.1073/pnas.2016858117
Aurélie Bertin , Nicola de Franceschi , Eugenio de la Mora , Sourav Maiti, Maryam Alqabandi, Nolwen Miguet, Aurélie di Cicco, Wouter H. Roos, Stéphanie Mangenot , Winfried Weissenhorn, Patricia Bassereau (2020 May 29)

Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation

Nature Communications : 11 : 2663 : DOI : 10.1038/s41467-020-16368-5

Year of publication 2019

Julien Pernier, Remy Kusters, Hugo Bousquet, Thibaut Lagny, Antoine Morchain, Jean-François Joanny*, Patricia Bassereau*, Evelyne Coudrier* (2019 Nov 15)

Myosin 1b is an actin depolymerase.

Nature Communications : 10 : 5200 : DOI : 10.1038/s41467-019-13160-y