Systems Biology of Cell Polarity and Cell Division

Team Members

Matthieu Piel, PhD

Matthieu Piel

Matthieu Piel CNRS Research Director Team Piel Team Leader Tel:

Research Gate
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Biography

    2018 : CNRS (DR1), UMR 144 Institut Curie, IPGG

    2014 : CNRS (DR2), UMR 144 Institut Curie

    2005 : CNRS (CR2), UMR 144 Institut Curie

    2002-2005 : Postdoctorate fellowship with Prof. Andrew Murray, Harvard University MCB Cambridge USA. Subject: Quantitative study of baker's yeast response to sexual pheromone: from microfluidc to conjugation.

    1997-2002 : PhD (defended in Nov 2001), laboratory of Dr. Michel Bornens, Institut Curie UMR 144 Paris FRANCE. Subject: Functional and cinetic study of mammalian cells centrosomes.

    1996-1997 : DEA Physique des Liquides, Université Paris-VI, Option Polymères et Cristaux Liquides

    1993-1996 : Ecole Polytechnique, Option Physique Expérimentale et Biophysique


 Awards

    2018 : Grand Prix Jean Hamburger of research in medicine from the City of Paris

    2016 : EMBO Membership

    2012 : Médaille de Bronze du CNRS

    2002 : Prix Nine Choucroun


 Patents

    2016 : Matthieu Piel, Matteo Gentili, Matthew Raab, Nicolas Manel - Method to monitor and quantify interphase nuclear envelope rupture events (US20190033311A1)

    2015 : Maël Le Berre, Matthieu Piel, Yanjun Liu - Device for Guiding Cell Migration and Method of Guiding Cell Migration Implementing Such a Device (US20150184122)

    2010 : Ana-Maria Lennon-Dumenil, Matthieu Piel - Agent modulateur de CD74 pour la régulation de la migration de cellules dendritiques et dispositif pour l'étude de la capacité de motilité d'une cellule (EP2198879A1)

    2004 : Bornens M, Thery M and Piel M - Methods and Device for Adhesive Control of Internal Cell Organization. (# PCT/1B2003/003091)

Key publications

Year of publication 2019

Clotilde Cadart, Larisa Venkova, Pierre Recho, Marco Cosentino Lagomarsino, Matthieu Piel (2019 Aug 19)

The physics of cell-size regulation across timescales

Nature Physics : 15 : 993–1004 : DOI : 10.1038/s41567-019-0629-y
Hélène D Moreau, Carles Blanch-Mercader, Rafaele Attia, Mathieu Maurin, Zahraa Alraies, Doriane Sanséau, Odile Malbec, Maria-Graciela Delgado, Philippe Bousso, Jean-François Joanny, Raphaël Voituriez, Matthieu Piel, Ana-Maria Lennon-Duménil (2019 Apr 16)

Macropinocytosis Overcomes Directional Bias in Dendritic Cells Due to Hydraulic Resistance and Facilitates Space Exploration.

Developmental cell : 171-188.e5 : DOI : S1534-5807(19)30235-7

Year of publication 2018

Clotilde Cadart, Sylvain Monnier, Jacopo Grilli, Pablo J Sáez, Nishit Srivastava, Rafaele Attia, Emmanuel Terriac, Buzz Baum, Marco Cosentino-Lagomarsino, Matthieu Piel (2018 Aug 18)

Size control in mammalian cells involves modulation of both growth rate and cell cycle duration.

Nature communications : 3275 : DOI : 10.1038/s41467-018-05393-0

Year of publication 2016

M Raab, M Gentili, H de Belly, H R Thiam, P Vargas, A J Jimenez, F Lautenschlaeger, Raphaël Voituriez, A M Lennon-Duménil, N Manel, M Piel (2016 Apr 15)

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

Science (New York, N.Y.) : DOI : 10.1126/science.aad7611
Hawa-Racine Thiam, Pablo Vargas, Nicolas Carpi, Carolina Lage Crespo, Matthew Raab, Emmanuel Terriac, Megan C King, Jordan Jacobelli, Arthur S Alberts, Theresia Stradal, Ana-Maria Lennon-Dumenil, Matthieu Piel (2016 Mar 16)

Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments.

Nature communications : 10997 : DOI : 10.1038/ncomms10997
Pablo Vargas, Paolo Maiuri, Marine Bretou, Pablo J Sáez, Paolo Pierobon, Mathieu Maurin, Mélanie Chabaud, Danielle Lankar, Dorian Obino, Emmanuel Terriac, Matthew Raab, Hawa-Racine Thiam, Thomas Brocker, Susan M Kitchen-Goosen, Arthur S Alberts, Praveen Sunareni, Sheng Xia, Rong Li, Raphael Voituriez, Matthieu Piel, Ana-Maria Lennon-Duménil (2016 Jan 8)

Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells.

Nature cell biology : 43-53 : DOI : 10.1038/ncb3284

Year of publication 2015

Ewa Zlotek-Zlotkiewicz, Sylvain Monnier, Giovanni Cappello, Mael Le Berre, Matthieu Piel (2015 Nov 25)

Optical volume and mass measurements show that mammalian cells swell during mitosis.

The Journal of cell biology : 765-74 : DOI : 10.1083/jcb.201505056
Paolo Maiuri, Jean-François Rupprecht, Stefan Wieser, Verena Ruprecht, Olivier Bénichou, Nicolas Carpi, Mathieu Coppey, Simon De Beco, Nir Gov, Carl-Philipp Heisenberg, Carolina Lage Crespo, Franziska Lautenschlaeger, Maël Le Berre, Ana-Maria Lennon-Dumenil, Matthew Raab, Hawa-Racine Thiam, Matthieu Piel, Michael Sixt, Raphaël Voituriez (2015 Apr 9)

Actin flows mediate a universal coupling between cell speed and cell persistence.

Cell : 374-86 : DOI : 10.1016/j.cell.2015.01.056
Yan-Jun Liu, Maël Le Berre, Franziska Lautenschlaeger, Paolo Maiuri, Andrew Callan-Jones, Mélina Heuzé, Tohru Takaki, Raphaël Voituriez, Matthieu Piel (2015 Feb 12)

Confinement and low adhesion induce fast amoeboid migration of slow mesenchymal cells.

Cell : 659-72 : DOI : 10.1016/j.cell.2015.01.007

Year of publication 2014

Ana Joaquina Jimenez, Paolo Maiuri, Julie Lafaurie-Janvore, Séverine Divoux, Matthieu Piel, Franck Perez (2014 Jan 30)

ESCRT machinery is required for plasma membrane repair.

Science (New York, N.Y.) : 1247136 : DOI : 10.1126/science.1247136

Year of publication 2013

Julie Lafaurie-Janvore, Paolo Maiuri, Irène Wang, Mathieu Pinot, Jean-Baptiste Manneville, Timo Betz, Martial Balland, Matthieu Piel (2013 Mar 29)

ESCRT-III assembly and cytokinetic abscission are induced by tension release in the intercellular bridge.

Science (New York, N.Y.) : 1625-9 : DOI : 10.1126/science.1233866

Year of publication 2011

Maria-Isabel Fernandez, Mélina L Heuzé, Carolina Martinez-Cingolani, Elisabetta Volpe, Marie-Helene Donnadieu, Matthieu Piel, Bernhard Homey, Ana-Maria Lennon-Duménil, Vassili Soumelis (2011 Jul 19)

The human cytokine TSLP triggers a cell-autonomous dendritic cell migration in confined environments.

Blood : 3862-9 : DOI : 10.1182/blood-2010-12-323089
Jenny Fink, Nicolas Carpi, Timo Betz, Angelique Bétard, Meriem Chebah, Ammar Azioune, Michel Bornens, Cecile Sykes, Luc Fetler, Damien Cuvelier, Matthieu Piel (2011 Jun 12)

External forces control mitotic spindle positioning.

Nature cell biology : 771-8 : DOI : 10.1038/ncb2269

Year of publication 2008

Gabrielle Faure-André, Pablo Vargas, Maria-Isabel Yuseff, Mélina Heuzé, Jheimmy Diaz, Danielle Lankar, Veronica Steri, Jeremy Manry, Stéphanie Hugues, Fulvia Vascotto, Jérôme Boulanger, Graça Raposo, Maria-Rosa Bono, Mario Rosemblatt, Matthieu Piel, Ana-Maria Lennon-Duménil (2008 Dec 17)

Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain.

Science (New York, N.Y.) : 1705-10 : DOI : 10.1126/science.1159894