Systems Biology of Cell Polarity and Cell Division

Team Members

Matthieu Piel, PhD

Matthieu Piel

Matthieu Piel CNRS Research Director Team Piel Team Leader Tel:

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Biography

    2018 : CNRS (DR1), UMR 144 Institut Curie, IPGG

    2014 : CNRS (DR2), UMR 144 Institut Curi

    2005 : CNRS (CR2), UMR 144 Institut Curie

    2002-2005 : Postdoctorate fellowship with Prof. Andrew Murray, Harvard University MCB Cambridge USA. Subject: Quantitative study of baker's yeast response to sexual pheromone: from microfluidc to conjugation.

    1997-2002 : PhD (defended in Nov 2001), laboratory of Dr. Michel Bornens, Institut Curie UMR 144 Paris FRANCE. Subject: Functional and cinetic study of mammalian cells centrosomes.

    1996-1997 : DEA Physique des Liquides, Université Paris-VI, Option Polymères et Cristaux Liquides

    1993-1996 : Ecole Polytechnique, Option Physique Expérimentale et Biophysique


 Awards

    2018 : Grand Prix Jean Hamburger of research in medicine from the City of Paris

    2016 : EMBO Membership

    2012 : Médaille de Bronze du CNRS

    2002 : Prix Nine Choucroun


 Patents

    2016 : Matthieu Piel, Matteo Gentili, Matthew Raab, Nicolas Manel - Method to monitor and quantify interphase nuclear envelope rupture events (US20190033311A1)

    2015 : Maël Le Berre, Matthieu Piel, Yanjun Liu - Device for Guiding Cell Migration and Method of Guiding Cell Migration Implementing Such a Device (US20150184122)

    2010 : Ana-Maria Lennon-Dumenil, Matthieu Piel - Agent modulateur de CD74 pour la régulation de la migration de cellules dendritiques et dispositif pour l'étude de la capacité de motilité d'une cellule (EP2198879A1)

    2004 : Bornens M, Thery M and Piel M - Methods and Device for Adhesive Control of Internal Cell Organization. (# PCT/1B2003/003091)

Key publications

Year of publication 2019

Clotilde Cadart, Larisa Venkova, Pierre Recho, Marco Cosentino Lagomarsino, Matthieu Piel (2019 Aug 19)

The physics of cell-size regulation across timescales

Nature Physics : 15 : 993–1004 : DOI : 10.1038/s41567-019-0629-y
Hélène D Moreau, Carles Blanch-Mercader, Rafaele Attia, Mathieu Maurin, Zahraa Alraies, Doriane Sanséau, Odile Malbec, Maria-Graciela Delgado, Philippe Bousso, Jean-François Joanny, Raphaël Voituriez, Matthieu Piel, Ana-Maria Lennon-Duménil (2019 Apr 16)

Macropinocytosis Overcomes Directional Bias in Dendritic Cells Due to Hydraulic Resistance and Facilitates Space Exploration.

Developmental cell : 171-188.e5 : DOI : S1534-5807(19)30235-7

Year of publication 2018

Clotilde Cadart, Sylvain Monnier, Jacopo Grilli, Pablo J Sáez, Nishit Srivastava, Rafaele Attia, Emmanuel Terriac, Buzz Baum, Marco Cosentino-Lagomarsino, Matthieu Piel (2018 Aug 18)

Size control in mammalian cells involves modulation of both growth rate and cell cycle duration.

Nature communications : 3275 : DOI : 10.1038/s41467-018-05393-0

Year of publication 2016

M Raab, M Gentili, H de Belly, H R Thiam, P Vargas, A J Jimenez, F Lautenschlaeger, Raphaël Voituriez, A M Lennon-Duménil, N Manel, M Piel (2016 Apr 15)

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

Science (New York, N.Y.) : DOI : 10.1126/science.aad7611
Hawa-Racine Thiam, Pablo Vargas, Nicolas Carpi, Carolina Lage Crespo, Matthew Raab, Emmanuel Terriac, Megan C King, Jordan Jacobelli, Arthur S Alberts, Theresia Stradal, Ana-Maria Lennon-Dumenil, Matthieu Piel (2016 Mar 16)

Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments.

Nature communications : 10997 : DOI : 10.1038/ncomms10997
Pablo Vargas, Paolo Maiuri, Marine Bretou, Pablo J Sáez, Paolo Pierobon, Mathieu Maurin, Mélanie Chabaud, Danielle Lankar, Dorian Obino, Emmanuel Terriac, Matthew Raab, Hawa-Racine Thiam, Thomas Brocker, Susan M Kitchen-Goosen, Arthur S Alberts, Praveen Sunareni, Sheng Xia, Rong Li, Raphael Voituriez, Matthieu Piel, Ana-Maria Lennon-Duménil (2016 Jan 8)

Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells.

Nature cell biology : 43-53 : DOI : 10.1038/ncb3284

Year of publication 2015

Paolo Maiuri, Jean-François Rupprecht, Stefan Wieser, Verena Ruprecht, Olivier Bénichou, Nicolas Carpi, Mathieu Coppey, Simon De Beco, Nir Gov, Carl-Philipp Heisenberg, Carolina Lage Crespo, Franziska Lautenschlaeger, Maël Le Berre, Ana-Maria Lennon-Dumenil, Matthew Raab, Hawa-Racine Thiam, Matthieu Piel, Michael Sixt, Raphaël Voituriez (2015 Apr 9)

Actin flows mediate a universal coupling between cell speed and cell persistence.

Cell : 374-86 : DOI : 10.1016/j.cell.2015.01.056

Year of publication 2014

Ana Joaquina Jimenez, Paolo Maiuri, Julie Lafaurie-Janvore, Séverine Divoux, Matthieu Piel, Franck Perez (2014 Jan 30)

ESCRT machinery is required for plasma membrane repair.

Science (New York, N.Y.) : 1247136 : DOI : 10.1126/science.1247136

Year of publication 2011

Maria-Isabel Fernandez, Mélina L Heuzé, Carolina Martinez-Cingolani, Elisabetta Volpe, Marie-Helene Donnadieu, Matthieu Piel, Bernhard Homey, Ana-Maria Lennon-Duménil, Vassili Soumelis (2011 Jul 19)

The human cytokine TSLP triggers a cell-autonomous dendritic cell migration in confined environments.

Blood : 3862-9 : DOI : 10.1182/blood-2010-12-323089

Year of publication 2008

Gabrielle Faure-André, Pablo Vargas, Maria-Isabel Yuseff, Mélina Heuzé, Jheimmy Diaz, Danielle Lankar, Veronica Steri, Jeremy Manry, Stéphanie Hugues, Fulvia Vascotto, Jérôme Boulanger, Graça Raposo, Maria-Rosa Bono, Mario Rosemblatt, Matthieu Piel, Ana-Maria Lennon-Duménil (2008 Dec 17)

Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain.

Science (New York, N.Y.) : 1705-10 : DOI : 10.1126/science.1159894