Biology of centrosomes and genetic instability

Team

RENATA BASTO

Biology of centrosomes and genetic instability

Known as the main microtubule organizing center of animal cells (MTOCs), the centrosome participates in the organization of the microtubule network within the cell. It is formed of two centrioles surrounded by a structured matrix of proteins called the pericentriolar material (PCM).

Twitter: @basto_lab

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Members

RENATA BASTO

Deputy Director of Research Unit

SIMON GEMBLE

Permanent Researcher

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ANTHONY SIMON

Engineer

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FRANCES EDWARDS

Post-Doctoral Researcher

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FEDERICA SCOTTO DI CARLO

Post-Doctoral Researcher

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Past members

ALIX GOUPIL

PhD Student

CLARA BASTO

Engineer

CAROLE PENNETIER

Technician

DAVIDE GAMBAROTTO

PhD Student

DELPHINE GOGENDEAU

Post-Doctoral Researcher

DIANA VARGAS-HURTADO

PhD Student

JEAN-PHILIPPE MORRETTON

Engineer

MADDALENA NANO

PhD Student

MARIA ALEXANDRA RUJANO

Post-Doctoral Researcher

NATHALIE DA-SILVA

Engineer assistant

Nos projets

Polyploid lobe from Drosophila melanogatser larvae

Polyploidy paradox

Fuseau mitotique cerveau neurodevelopement

Mitotic spindle morphogenesis and function

Centrosome number alterations in cancer

Key publications

2023

Experimental Approaches to Generate and Isolate Human Tetraploid Cells
Methods in Molecular Biology

Sara Vanessa Bernhard, Simon Gemble, Renata Basto, Zuzana Storchova
(2023 01 Jan)
2022

Illuminati: a form of gene expression plasticity in Drosophila neural stem cells
Development

Alix Goupil, Jan Peter Heinen, Riham Salame, Fabrizio Rossi, Jose Reina, Carole Pennetier, Anthony Simon, Patricia Skorski, Anxela Louzao, Allison J. Bardin, Renata Basto, Cayetano Gonzalez
(2022 15 Nov)
2022

A catalog of numerical centrosome defects in epithelial ovarian cancers
EMBO Molecular Medicine

Jean‐Philippe Morretton, Anthony Simon, Aurélie Herbette, Jorge Barbazan, Carlos Pérez‐González, Camille Cosson, Bassirou Mboup, Aurélien Latouche, Tatiana Popova, Yann Kieffer, Anne‐Sophie Macé, Pierre Gestraud, Guillaume Bataillon, Véronique Becette, Didier Meseure, André Nicolas, Odette Mariani, Anne Vincent‐Salomon, Marc‐Henri Stern, Fatima Mechta‐Grigoriou, Sergio Roman Roman, Danijela Matic Vignjevic, Roman Rouzier, Xavier Sastre‐Garau, Oumou Goundiam, Renata Basto
(2022 07 Sep)
2022

Genetic instability from a single S phase after whole-genome duplication
Nature

Simon Gemble, René Wardenaar, Kristina Keuper, Nishit Srivastava, Maddalena Nano, Anne-Sophie Macé, Andréa E. Tijhuis, Sara Vanessa Bernhard, Diana C. J. Spierings, Anthony Simon, Oumou Goundiam, Helfrid Hochegger, Matthieu Piel, Floris Foijer, Zuzana Storchová, Renata Basto
(2022 07 Apr)
2022

Microvilli-derived extracellular vesicles carry Hedgehog morphogenic signals for Drosophila wing imaginal disc development
Current Biology

Ilse Hurbain, Anne-Sophie Macé, Maryse Romao, Elodie Prince, Lucie Sengmanivong, Laurent Ruel, Renata Basto, Pascal P. Thérond, Graça Raposo, Gisela D’Angelo
(2022 01 Jan)
2021

Centrosomes in disease: how the same music can sound so different?
Current Opinion in Structural Biology

Oumou Goundiam, Renata Basto
(2021 01 Feb)
2020

CHRONOCRISIS: When Cell Cycle Asynchrony Generates DNA Damage in Polyploid Cells
BioEssays

Simon Gemble, Renata Basto
(2020 01 Oct)
2020

Centrosomes: The good and the bad for brain development
Biology of the Cell

Véronique Marthiens, Renata Basto
(2020 01 Jun)
2020

Chromosomes function as a barrier to mitotic spindle bipolarity in polyploid cells
Journal of Cell Biology

Alix Goupil, Maddalena Nano, Gaëlle Letort, Simon Gemble, Frances Edwards, Oumou Goundiam, Delphine Gogendeau, Carole Pennetier, Renata Basto
(2020 06 Apr)
2019

Cell-Cycle Asynchrony Generates DNA Damage at Mitotic Entry in Polyploid Cells
Current Biology

Maddalena Nano, Simon Gemble, Anthony Simon, Carole Pennetier, Vincent Fraisier, Veronique Marthiens, Renata Basto
(2019 01 Nov)
2019

Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity
Current Biology

Simon Gemble, Anthony Simon, Carole Pennetier, Marie Dumont, Solène Hervé, Franz Meitinger, Karen Oegema, Raphaël Rodriguez, Geneviève Almouzni, Daniele Fachinetti, Renata Basto
(2019 01 Sep)
2019

Differences in Mitotic Spindle Architecture in Mammalian Neural Stem Cells Influence Mitotic Accuracy during Brain Development
Current Biology

Diana Vargas-Hurtado, Jean-Baptiste Brault, Tristan Piolot, Ludovic Leconte, Nathalie Da Silva, Carole Pennetier, Alexandre Baffet, Véronique Marthiens, Renata Basto
(2019 01 Sep)
2019

Plk4 Regulates Centriole Asymmetry and Spindle Orientation in Neural Stem Cells
Developmental Cell

Davide Gambarotto, Carole Pennetier, John M. Ryniawec, Daniel W. Buster, Delphine Gogendeau, Alix Goupil, Maddalena Nano, Anthony Simon, Damien Blanc, Victor Racine, Yuu Kimata, Gregory C. Rogers, Renata Basto
(2019 01 Jul)
2018

Fast and furious . . . or not, Plk4 dictates the pace
Journal of Cell Biology

Simon Gemble, Renata Basto
(2018 02 Apr)

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