UMR144 – Subcellular Structure and Cellular Dynamics

The mission of this unit is to understand the biogenesis of the cell compartments and the molecular mechanisms that govern normal cellular functions.

The main research themes of the unit include:

  • Transport pathways between compartments,
  • The dynamics of the actin- and microtubule-based cytoskeletons,
  • Three-dimensional structures of molecular motors,
  • Mechanisms of cell division and cell migration,
  • The mechanisms involved in establishing the polarity of epithelia and their differentiation,
  • Signalling pathways associated with tumour progression in several mouse models and human tumours,
  • Regulation of adhesive systems during morphogenesis and development.

Key publications

Year of publication 2018

Philip D Stahl, Graça Raposo (2018 May 17)

Exosomes and extracellular vesicles: the path forward.

Essays in biochemistry : 119-124 : DOI : 10.1042/EBC20170088
Guillaume van Niel, Gisela D'Angelo, Graça Raposo (2018 Jan 18)

Shedding light on the cell biology of extracellular vesicles.

Nature reviews. Molecular cell biology : 213-228 : DOI : 10.1038/nrm.2017.125
Frederik Johannes Verweij, Maarten P Bebelman, Connie R Jimenez, Juan J Garcia-Vallejo, Hans Janssen, Jacques Neefjes, Jaco C Knol, Richard de Goeij-de Haas, Sander R Piersma, S Rubina Baglio, Matthijs Verhage, Jaap M Middeldorp, Anoek Zomer, Jacco van Rheenen, Marc G Coppolino, Ilse Hurbain, Graça Raposo, Martine J Smit, Ruud F G Toonen, Guillaume van Niel, D Michiel Pegtel (2018 Jan 18)

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

The Journal of cell biology : 1129-1142 : DOI : 10.1083/jcb.201703206

Year of publication 2017

Alexandros Glentis, Philipp Oertle, Pascale Mariani, Aleksandra Chikina, Fatima El Marjou, Youmna Attieh, Francois Zaccarini, Marick Lae, Damarys Loew, Florent Dingli, Philemon Sirven, Marie Schoumacher, Basile G Gurchenkov, Marija Plodinec, Danijela Matic Vignjevic (2017 Oct 15)

Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane.

Nature communications : 924 : DOI : 10.1038/s41467-017-00985-8
Koceila Aizel, Andrew G Clark, Anthony Simon, Sara Geraldo, Anette Funfak, Pablo Vargas, Jérôme Bibette, Danijela Matic Vignjevic, Nicolas Bremond (2017 Oct 13)

A tuneable microfluidic system for long duration chemotaxis experiments in a 3D collagen matrix.

Lab on a chip : DOI : 10.1039/c7lc00649g
Youmna Attieh, Andrew G Clark, Carina Grass, Sophie Richon, Marc Pocard, Pascale Mariani, Nadia Elkhatib, Timo Betz, Basile Gurchenkov, Danijela Matic Vignjevic (2017 Sep 22)

Cancer-associated fibroblasts lead tumor invasion through integrin-β3-dependent fibronectin assembly.

The Journal of cell biology : DOI : jcb.201702033