UMR144 – Cell biology and cancer

The mission of this unit is to understand the biogenesis of the cell compartments and the molecular mechanisms that govern normal cellular functions.

The main research themes of the unit include:

  • Transport pathways between compartments,
  • The dynamics of the actin- and microtubule-based cytoskeletons,
  • Three-dimensional structures of molecular motors,
  • Mechanisms of cell division and cell migration,
  • The mechanisms involved in establishing the polarity of epithelia and their differentiation,
  • Signalling pathways associated with tumour progression in several mouse models and human tumours,
  • Regulation of adhesive systems during morphogenesis and development.

Key publications

Year of publication 2019

Marie Dumont, Riccardo Gamba, Pierre Gestraud, Sjoerd Klaasen, Joseph T Worrall, Sippe G De Vries, Vincent Boudreau, Catalina Salinas-Luypaert, Paul S Maddox, Susanne Ma Lens, Geert Jpl Kops, Sarah E McClelland, Karen H Miga, Daniele Fachinetti (2019 Nov 22)

Human chromosome-specific aneuploidy is influenced by DNA-dependent centromeric features.

The EMBO journal : e102924 : DOI : 10.15252/embj.2019102924
Simon Gemble, Anthony Simon, Carole Pennetier, Marie Dumont, Solène Hervé, Franz Meitinger, Karen Oegema, Raphaël Rodriguez, Geneviève Almouzni, Daniele Fachinetti, Renata Basto (2019 Sep 10)

Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity.

Current biology : CB : 3072-3080.e5 : DOI : S0960-9822(19)30932-7
Andrea Scelfo, Daniele Fachinetti (2019 Aug 21)

Keeping the Centromere under Control: A Promising Role for DNA Methylation.

Cells : DOI : E912
Clotilde Cadart, Larisa Venkova, Pierre Recho, Marco Cosentino Lagomarsino, Matthieu Piel (2019 Aug 19)

The physics of cell-size regulation across timescales

Nature Physics : 15 : 993–1004 : DOI : 10.1038/s41567-019-0629-y
Denis Krndija, Fatima El Marjou, Boris Guirao, Sophie Richon, Olivier Leroy, Yohanns Bellaiche, Edouard Hannezo, Danijela Matic Vignjevic. (2019 Aug 16)

Active cell migration is critical for steady-state epithelial turnover in the gut.

Science : 365(6454) : 705-710 : DOI : 10.1126/science.aau3429
Federica Arbizzani, Sergio A Rincon, Anne Paoletti (2019 Jun 21)

Increasing ergosterol levels delays formin-dependent assembly of F-actin cables and disrupts division plane positioning.

Journal of cell science : DOI : jcs.227447