UMR144 – Cell biology and cancer

The mission of this unit is to understand the biogenesis of the cell compartments and the molecular mechanisms that govern normal cellular functions.

The main research themes of the unit include:

  • Transport pathways between compartments,
  • The dynamics of the actin- and microtubule-based cytoskeletons,
  • Three-dimensional structures of molecular motors,
  • Mechanisms of cell division and cell migration,
  • The mechanisms involved in establishing the polarity of epithelia and their differentiation,
  • Signalling pathways associated with tumour progression in several mouse models and human tumours,
  • Regulation of adhesive systems during morphogenesis and development.

Key publications

Year of publication 2019

Denis Krndija, Fatima El Marjou, Boris Guirao, Sophie Richon, Olivier Leroy, Yohanns Bellaiche, Edouard Hannezo, Danijela Matic Vignjevic. (2019 Aug 16)

Active cell migration is critical for steady-state epithelial turnover in the gut.

Science : 365(6454) : 705-710 : DOI : 10.1126/science.aau3429
Federica Arbizzani, Sergio A Rincon, Anne Paoletti (2019 Jun 21)

Increasing ergosterol levels delays formin-dependent assembly of F-actin cables and disrupts division plane positioning.

Journal of cell science : DOI : jcs.227447
Lou Fourriere, Amal Kasri, Nelly Gareil, Sabine Bardin, Hugo Bousquet, David Pereira, Franck Perez, Bruno Goud, Gaelle Boncompain, Stéphanie Miserey-Lenkei (2019 May 31)

RAB6 and microtubules restrict protein secretion to focal adhesions.

The Journal of cell biology : DOI : 10.1083/jcb.201805002
Matteo Gentili, Xavier Lahaye, Francesca Nadalin, Guilherme P F Nader, Emilia Puig Lombardi, Solène Herve, Nilushi S De Silva, Derek C Rookhuizen, Elina Zueva, Christel Goudot, Mathieu Maurin, Aurore Bochnakian, Sebastian Amigorena, Matthieu Piel, Daniele Fachinetti, Arturo Londoño-Vallejo, Nicolas Manel (2019 Mar 28)

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus.

Cell reports : 3798 : DOI : S2211-1247(19)30365-1
Isabelle Loiodice, Marcel E Janson, Penny Tavormina, Sebastien Schaub, Divya Bhatt, Ryan Cochran, Julie Czupryna, Chuanhai Fu, Phong T Tran (2019 Mar 7)

Quantifying Tubulin Concentration and Microtubule Number Throughout the Fission Yeast Cell Cycle.

Biomolecules : DOI : E86
Lara Katharina Krüger, Jérémie-Luc Sanchez, Anne Paoletti, Phong Thanh Tran (2019 Feb 27)

Kinesin-6 regulates cell-size-dependent spindle elongation velocity to keep mitosis duration constant in fission yeast.

eLife : DOI : 10.7554/eLife.42182