UMR144 – Cell biology and cancer

The mission of this unit is to understand the biogenesis of the cell compartments and the molecular mechanisms that govern normal cellular functions.

The main research themes of the unit include:

  • Transport pathways between compartments,
  • The dynamics of the actin- and microtubule-based cytoskeletons,
  • Three-dimensional structures of molecular motors,
  • Mechanisms of cell division and cell migration,
  • The mechanisms involved in establishing the polarity of epithelia and their differentiation,
  • Signalling pathways associated with tumour progression in several mouse models and human tumours,
  • Regulation of adhesive systems during morphogenesis and development.

Key publications

Year of publication 2021

Daniel Jeffery, Alberto Gatto, Katrina Podsypanina, Charlène Renaud-Pageot, Rebeca Ponce Landete, Lorraine Bonneville, Marie Dumont, Daniele Fachinetti, Geneviève Almouzni (2021 Mar 26)

CENP-A overexpression promotes distinct fates in human cells, depending on p53 status

Communications Biology : 4 : 1-18 : DOI : 10.1038/s42003-021-01941-5
Simona Giunta, Solène Hervé, Ryan R White, Therese Wilhelm, Marie Dumont, Andrea Scelfo, Riccardo Gamba, Cheng Kit Wong, Giulia Rancati, Agata Smogorzewska, Hironori Funabiki, Daniele Fachinetti (2021 Mar 3)

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy.

Proceedings of the National Academy of Sciences of the United States of America : DOI : e2015634118

Year of publication 2020

A J Lomakin, C J Cattin, D Cuvelier, Z Alraies, M Molina, G P F Nader, N Srivastava, P J Sáez, J M Garcia-Arcos, I Y Zhitnyak, A Bhargava, M K Driscoll, E S Welf, R Fiolka, R J Petrie, N S De Silva, J M González-Granado, N Manel, A M Lennon-Duménil, D J Müller, M Piel (2020 Oct 16)

The nucleus acts as a ruler tailoring cell responses to spatial constraints.

Science (New York, N.Y.) : DOI : eaba2894
Dihia Moussaoui, James P Robblee, Daniel Auguin, Elena B Krementsova, Silvia Haase, Thomas Ca Blake, Jake Baum, Julien Robert-Paganin, Kathleen M Trybus, Anne Houdusse (2020 Oct 13)

Full-length myosin A and essential light chain PfELC structures provide new anti-malarial targets.

eLife : DOI : 10.7554/eLife.60581
Máté Gyimesi, Ádám I Horváth, Demeter Túrós, Sharad Kumar Suthar, Máté Pénzes, Csilla Kurdi, Louise Canon, Carlos Kikuti, Kathleen M Ruppel, Darshan V Trivedi, James A Spudich, István Lőrincz, Anna Á Rauscher, Mihály Kovács, Endre Pál, Sámuel Komoly, Anne Houdusse, András Málnási-Csizmadia (2020 Oct 9)

Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness.

Cell : 335-346.e13 : DOI : S0092-8674(20)31138-7
Aleksandra S Chikina, Francesca Nadalin, Mathieu Maurin, Mabel San-Roman, Thibault Thomas-Bonafos, Xin V Li, Sonia Lameiras, Sylvain Baulande, Sandrine Henri, Bernard Malissen, Livia Lacerda Mariano, Jorge Barbazan, J Magarian Blander, Iliyan D Iliev, Danijela Matic Vignjevic, Ana-Maria Lennon-Duménil (2020 Sep 24)

Macrophages Maintain Epithelium Integrity by Limiting Fungal Product Absorption.

Cell : 411-428.e16 : DOI : S0092-8674(20)31090-4