The objective of the Chemical Biology of Membranes and Therapeutic Delivery Unit is to use the power of synthetic chemistry to create innovative tools for the study and manipulation of membrane biological systems. This establishes a competitive basis for discovery at the forefront of biomedical research.
Our chemical biology research program has the potential to simultaneously produce novel insights into fundamental biological mechanisms, deliver new targets, and supply small-molecule modulators of target activity.
Specifically, we are addressing the following major challenges using these interdisciplinary approaches:
- targeted delivery of compounds to tumors/immunotherapy
- small molecule lead discovery (chemical genetics)
- lysosomotropic targeting
- glycosphingolipid localization and function
- membrane mechanics
- Chem-Seq/ Drug-Seq
- vectorial proteomics
- intracellular signaling
The unit is also involved in the Institut Curie chemical Library platform