UMR3666/U1143 – Chemical Biology of Membranes and Therapeutic Delivery

The overall objective of the Chemical Biology of Membranes and Therapeutic Delivery unit is to use the enabling power of synthetic chemistry to create novel chemical structures and innovative tools for the study and manipulation of membrane biological systems such as to establish a competitive basis for discovery at the forefront of cognitive science and biomedical research.

We believe that our chemical biology research program has the potential to simultaneously produce novel insights into fundamental biological mechanisms, deliver new targets, and supply small-molecule modulators of target activity.

Specifically, we will address the following major challenges using chemical biology approaches: novel formulations for targeted delivery of therapeutic compounds to tumors, and for tumor immunotherapy; small molecules for discovery and biomedical research (chemical genetics); glycosphingolipid localization and function; vectorial proteomics; membrane mechanics, mechanotransduction, and intracellular signaling.

The Unit is also involved in the Chemical Library (platform of the Curie Institute)

Key publications

Year of publication 2017

Guillaume Kellermann, Florent Dingli, Vanessa Masson, Daniel Dauzonne, Evelyne Ségal-Bendirdjian, Marie-Paule Teulade-Fichou, Damarys Loew, Sophie Bombard (2017 Feb 11)

Exploring the mechanism of inhibition of human telomerase by cysteine-reactive compounds.

FEBS letters : DOI : 10.1002/1873-3468.12589

Year of publication 2016

Mijo Simunovic, Emma Evergren, Ivan Golushko, Coline Prévost, Henri-François Renard, Ludger Johannes, Harvey T McMahon, Vladimir Lorman, Gregory A Voth, Patricia Bassereau (2016 Oct 4)

How curvature-generating proteins build scaffolds on membrane nanotubes.

Proceedings of the National Academy of Sciences of the United States of America : 113 : DOI : 10.1073/pnas.1606943113

Year of publication 2015

Ahmed Alouane, Raphaël Labruère, Thomas Le Saux, Frédéric Schmidt*, Ludovic Jullien* (2015 Jun 9)

Self-immolative spacers: kinetic aspects, structure-property relationships, and applications.

Angewandte Chemie (International ed. in English) : 7492-509 : DOI : 10.1002/anie.201500088
Florence Mahuteau-Betzer (2015 May 12)

The French National Compound Library: advances and future prospects.

Médecine sciences : M/S : 31 : 417-22 : DOI : 10.1051/medsci/20153104016
Guillaume Kellermann, Markus Kaiser, Florent Dingli, Olivier Lahuna, Delphine Naud-Martin, Florence Mahuteau-Betzer, Damarys Loew, Evelyne Ségal-Bendirdjian, Marie-Paule Teulade-Fichou, Sophie Bombard (2015 May 11)

Identification of human telomerase assembly inhibitors enabled by a novel method to produce hTERT.

Nucleic acids research : e99 : DOI : 10.1093/nar/gkv425
Henri-François Renard, Mijo Simunovic, Joël Lemière, Emmanuel Boucrot, Maria Daniela Garcia-Castillo, Senthil Arumugam, Valérie Chambon, Christophe Lamaze, Christian Wunder, Anne K Kenworthy, Anne A Schmidt, Harvey T McMahon, Cécile Sykes, Patricia Bassereau, Ludger Johannes (2015 Jan 22)

Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis.

Nature : 493-6 : DOI : 10.1038/nature14064