UMR3666/U1143 – Chemical Biology of Membranes and Therapeutic Delivery

The objective of the Chemical Biology of Membranes and Therapeutic Delivery Unit is to use the power of synthetic chemistry to create innovative tools for the study and manipulation of membrane biological systems. This establishes a competitive basis for discovery at the forefront of biomedical research.

Our chemical biology research program has the potential to simultaneously produce novel insights into fundamental biological mechanisms, deliver new targets, and supply small-molecule modulators of target activity.

Specifically, we are addressing the following major challenges using these interdisciplinary approaches:

  • targeted delivery of compounds to tumors/immunotherapy
  • small molecule lead discovery (chemical genetics)
  • lysosomotropic targeting
  • glycosphingolipid localization and function
  • membrane mechanics
  • Chem-Seq/ Drug-Seq
  • vectorial proteomics
  • mechanotransduction
  • intracellular signaling

The unit is also involved in the Institut Curie chemical Library platform 

Key publications

Year of publication 2017

Trang Thi Mai, Ahmed Hamaï, Antje Hienzsch, Tatiana Cañeque, Sebastian Müller, Julien Wicinski, Olivier Cabaud, Christine Leroy, Amandine David, Verónica Acevedo, Akihide Ryo, Christophe Genestier, Daniel Birnbaum, Emmanuelle Charafe-Jauffret, Patrice Codogno, Maryam Mehrpour, Raphaël Rodriguez (2017 May 15)

Salinomycin kills cancer stem cells by sequestering iron in lysosomes

Nature Chemistry : DOI : 10.1038/nchem.2778
Emmanouil Zacharioudakis, Poonam Agarwal, Alexandra Bartoli, Nathan Abell, Lavaniya Kunalingam, Valérie Bergoglio, Blerta Xhemalce, Kyle M. Miller, Raphaël Rodriguez (2017 May 5)

Chromatin Regulates Genome Targeting with Cisplatin

Angewandte Chemie : DOI : 10.1002/anie.201701144
Guillaume Kellermann, Florent Dingli, Vanessa Masson, Daniel Dauzonne, Evelyne Ségal-Bendirdjian, Marie-Paule Teulade-Fichou, Damarys Loew, Sophie Bombard (2017 Mar 1)

Exploring the mechanism of inhibition of human telomerase by cysteine-reactive compounds.

FEBS letters : 591 : 863-874 : DOI : 10.1002/1873-3468.12589
Weria Pezeshkian, Haifei Gao, Senthil Arumugam, Ulrike Becken, Patricia Bassereau, Jean-Claude Florent, John Hjort Ipsen, Ludger Johannes, Julian C Shillcock (2017 Jan 24)

Mechanism of Shiga Toxin Clustering on Membranes

ACS Nano : 11 : 314-324 : DOI : DOI: 10.1021/acsnano.6b05706
Nathan S Abell, Marvin Mercado, Tatiana Cañeque, Raphaël Rodriguez, Blerta Xhemalce (2017 Jan 18)

Click Quantitative Mass Spectrometry Identifies PIWIL3 as a Mechanistic Target of RNA Interference Activator Enoxacin in Cancer Cells.

Journal of the American Chemical Society : 1400-1403 : DOI : 10.1021/jacs.6b11751

Year of publication 2016

Blouin CM, Hamon Y, Gonnord P, Boularan C, Kagan J, Viaris de Lesegno C, Ruez R, Mailfert S, Bertaux N, Loew D, Wunder C, Johannes L,Vogt G, Contreras FX, Marguet D, Casanova JL, Galès C, He HT, Lamaze C. (2016 Dec 11)

Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation

Cell : Volume 166, Issue 4 : 920–934 : DOI : doi.org/10.1016/j.cell.2016.07.003