LABEX DCBIOL

The DCBIOL LabEx gathers ten teams of the Institut Curie in Paris and three from the Center of Immunology of Marseille-Luminy. It focuses on the study of the biology of dendritic cells. These latest, patrol boats of the organism, allow our immune system to react to pathogen agents, infected cells or cancerous cells. In 1973, the discovery of dendritic cells enabled Ralf Steinmann to obtain the Nobel Price of Physiology and medicine.

Sebastian Amigorena and Bernard Malissen, LabEx coordinators, started this program convinced that if dendritic cell biology was better understood, it would be possible to use their capacities in order to develop treatments against cancer.

The LabEx was officially started in autumn 2013. The heart of the Labex bits in laboratories at ” the lab bench”.

Main topics of research of DCBIOL:

  1. Epigenetic control of immune cell commitment
  2. Definition of DC subtypes in secondary lymphoid organs and tumors
  3. Innate DC functions and adjuvants
  4. Antigen presentation by DCs
  5. DC migration
  6. DC and T cell activation/differentiation
  7. DC and T cells in tumor microenvironment

DCBIOL recent achievements 2017-2018

  • 5th Annual retreats: March 2018 in Marseille
  • 5th Annual DC Biology course:  March 2018 in Marseille
  • 2nd Annual Inter-LabEx Meeting in Paris: Nov 2017 with 6 other LabEx in immunology
  • Sponsoring of 3 congresses: Conference Young Researchers in Life Sciences May 2017, “Club Francophone des Cellules Dendritiques”, Club Endo-Exo May 2018
  • Sponsoring of the Fanzine “Globule” on Dendritic Cell for children in 2017
  • Inauguration of the clinical part of the Center of Cancer Immunotherapies at Institut Curie: February 2018
  • 4 patents filed
  • Creation of 2 start-ups: Stimunity, Honing (common with CelTisPhyBio)

Coming:

  • 3rd Annual Inter-Labex Meeting in Paris: 21-22 Nov 2018
  • 6th Annual DC Biology course:  3 days 27-30 March 2019 in Lisbon in collaboration with Fondation Champalimaud and the IMOCA industrial chair shared with Sanofi
  • Creation of 2 additional start-ups
  • 2 patents in preparation
  • Sponsoring of 4 congresses: StemCellMathLab, Imaging the immune system, Systems Biology of Cancer, Quantitative Analysis of Clonality in Hematopoiesis in Sept 2018

Selection of 2017-2018 publications of the LabEx:

  1. The epigenetic control of stemness in CD8+ T cell fate commitment. Pace L, … Amigorena S. et al. Science. 2018 Jan 12;359(6372):177-186.
  2. Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages. Goudot C, .. Amigorena S, Segura E. et al. Immunity. 2017 Sep 19;47(3):582-596.e6.
  3. Constitutive resistance to viral infection in human CD141+ dendritic cells. Silvin A, … Manel N. et al. Sci Immunol. 2017 Jul 7;2(13). pii: eaai8071.
  4. Mapping the human DC lineage through the integration of high-dimensional techniques. See P, et al. Science. 2017 Jun 9;356(6342).
  5. Antigen-Primed CD8+ T Cells Call DCs for Back Up. Burbage M, Amigorena S. Immunity. 2017 Feb 21;46(2):163-164.