Research at the interface between physics and biology has been intensely pursued over the last 15 years at the Institut Curie. Nowadays, it is a hallmark of the Institut and greatly contributes to its international reputation. The main ambition of our Labex is to give a new impulse to the collaborations between physicists and biologists. Since its inception last year, several actions have been initiated, including a post-doctoral program that has allowed the funding of 5 post-docs and 6 research projects, the recruitment of one engineer for the imaging platform and the creation of one Chair of Excellence.  In the coming years, we wish to amplify these actions in order to strengthen the links between the Labex teams and to favor the emergence of new collaborative and ambitious projects. With this first Labex retreat, we had the opportunity to know better each other, both scientifically and personally, and also to discuss how the Labex can further help the research