Innate Immunity

Nicolas Manel

Nicolas Manel Team Leader, DR2 INSERM

Please go the lab website.

Innate immunity is an ancient and universal form of defence against damages, threats and pathogens such as viruses.

How the innate immunity distinguishes self from non-self (e.g. viruses) inside cells remains poorly understood. As a result, the ability to exploit innate immunity for anti-viral treatments, vaccines or cancer immunotherapy has remained limited.

The lab investigates the regulation, function and application of innate immunity.

Our goal is to discover the molecular mechanisms that enable the immune system to distinguish self from non-self inside cells. We study HIV, other viruses and auto-immunity and development of the immune system. We use primary human immune cells, mouse models, cell lines and computational tools. We develop applications of our research for clinical use.

Key publications

Year of publication 2020

A J Lomakin, C J Cattin, D Cuvelier, Z Alraies, M Molina, G P F Nader, N Srivastava, P J Sáez, J M Garcia-Arcos, I Y Zhitnyak, A Bhargava, M K Driscoll, E S Welf, R Fiolka, R J Petrie, N S De Silva, J M González-Granado, N Manel, A M Lennon-Duménil, D J Müller, M Piel (2020 Oct 16)

The nucleus acts as a ruler tailoring cell responses to spatial constraints.

Science (New York, N.Y.) : DOI : eaba2894
Johnson JS1, De Veaux N2, Rives AW2, Lahaye X3, Lucas SY4, Perot BP5, Luka M5, Garcia-Paredes V5, Amon LM4, Watters A2, Abdessalem G5, Aderem A6, Manel N3, Littman DR7, Bonneau R8, Ménager MM9. (2020 Jan 21)

A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV.

Cell reports : 30 : Cell Rep. 2020 Jan 21;30(3):914-931.e9. doi: 10.1016/j.celrep.2019.12.054. : 914,931 : DOI : 10.1016/j.celrep.2019.12.054

Year of publication 2019

Haifa B1, Ines Z1, Manel N2, Amira D3, Sonia Z3, Laila N2, Houda M4, Anis H1, Raja F1. (2019 Oct 14)

Clear cell gynecologic carcinomas: about 5 cases.

The Pan African Medical Journal : 34 : 87 : DOI : 10.11604/pamj.2019.34.87.18505
Gratia M1,2,3, Rodero MP4,5, Conrad C1, Bou Samra E2,3, Maurin M1, Rice GI6, Duffy D7, Revy P4, Petit F8, Dale RC9, Crow YJ#10,5,11, Amor-Gueret M#12,3,13, Manel N#14. (2019 May 6)

Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS.

Journal of experimental medecine : 216(5) : 1199-1213 : DOI : 10.1084/jem.20181329
Gentili M1, Lahaye X1, Nadalin F1, Nader GPF2, Puig Lombardi E3, Herve S4, De Silva NS1, Rookhuizen DC1, Zueva E1, Goudot C1, Maurin M1, Bochnakian A1, Amigorena S1, Piel M2, Fachinetti D4, Londoño-Vallejo A3, Manel N5. (2019 Feb 26)

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus.

Cell reports : 26(9) : 2377-2393 : DOI : 10.1016/j.celrep.2019.01.105
Manel N1, Di Santo JP2. (2019 Feb 2)

Editorial overview: Pillars of innate immunity: constantly learning and trying to remember. Manel N1,

Current opinion in immunology : 56 : DOI : 10.1016/j.coi.2019.03.002
All publications