Integrative analysis of T cell activation

T cells play a key role in the immune response against pathogens and tumor cells. The response of T lymphocytes is therefore one of the preferred targets of immunotherapy.  We apply multidisciplinary approaches that combine high resolution fluorescence microscopy, biochemistry, cell biology and mouse models, to elucidate how T cells are activated. Our goal is to determine the potential of these new mechanisms as future drug targets for immunotherapies.