U932 – Immunity and Cancer

Teams in this unit work to better understand the immunological responses to tumours, and to learn how to use the immune system to fight cancer.

Research projects range from analysis of the most fundamental aspects of intracellular transport in cells of the immune system to functional aspects of immune responses to tumours in animal models and to clinical immunotherapy in cancer patients. Approaches include, on one hand molecular biology, biochemistry and imaging techniques, based on both in vitro and in vivo experimental models, and on the other hand, immunomonitoring, diagnosis, prognosis and immunotherapeutic studies in cancer patients.

U932 retreat group photo

Key publications

Year of publication 2020

Johnson JS1, De Veaux N2, Rives AW2, Lahaye X3, Lucas SY4, Perot BP5, Luka M5, Garcia-Paredes V5, Amon LM4, Watters A2, Abdessalem G5, Aderem A6, Manel N3, Littman DR7, Bonneau R8, Ménager MM9. (2020 Jan 21)

A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV.

Cell reports : 30 : Cell Rep. 2020 Jan 21;30(3):914-931.e9. doi: 10.1016/j.celrep.2019.12.054. : 914,931 : DOI : 10.1016/j.celrep.2019.12.054

Year of publication 2019

Salou M, Lantz O. (2019 Nov 1)

A TCR-Dependent Tissue Repair Potential of MAIT Cells.

Trends in immunology : 40(11) : 975-977 : DOI : 10.1016/j.it.2019.09.001
Kondratova M1, Czerwinska U1,2, Sompairac N1,2, Amigorena SD3, Soumelis V3, Barillot E1, Zinovyev A1, Kuperstein I4. (2019 Oct 22)

A multiscale signalling network map of innate immune response in cancer reveals cell heterogeneity signatures.

Nature communications : 10 : Nat Commun. 2019 Oct 22;10(1):4808. doi: 10.1038/s41467-019-12270-x. : 4808 : DOI : 10.1038/s41467-019-12270-x
Haifa B1, Ines Z1, Manel N2, Amira D3, Sonia Z3, Laila N2, Houda M4, Anis H1, Raja F1. (2019 Oct 14)

Clear cell gynecologic carcinomas: about 5 cases.

The Pan African Medical Journal : 34 : 87 : DOI : 10.11604/pamj.2019.34.87.18505

Year of publication 2017

Goudot C1, Coillard A1, Villani AC2, Gueguen P1, Cros A1, Sarkizova S3, Tang-Huau TL4, Bohec M5, Baulande S5, Hacohen N2, Amigorena S1, Segura E6. (2019 Sep 19)

Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages.

Immunity : 47 : Immunity. 2017 Sep 19;47(3):582-596.e6. doi: 10.1016/j.immuni.2017.08.016. : 582,596 : DOI : 10.1016/j.immuni.2017.08.016

Year of publication 2019

Scepanovic P, Hodel F, Mondot S, Partula V, Byrd A, Hammer C, Alanio C, Bergstedt J, Patin E, Touvier M, Lantz O, Albert ML, Duffy D, Quintana-Murci L, Fellay J; Milieu Intérieur Consortium. (2019 Sep 13)

xA comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals.

: 13;7(1) : 130 : DOI : 10.1186/s40168-019-0747-x