U932 – Immunity and Cancer

Teams in this unit work to better understand the immunological responses to tumours, and to learn how to use the immune system to fight cancer.

Research projects range from analysis of the most fundamental aspects of intracellular transport in cells of the immune system to functional aspects of immune responses to tumours in animal models and to clinical immunotherapy in cancer patients. Approaches include, on one hand molecular biology, biochemistry and imaging techniques, based on both in vitro and in vivo experimental models, and on the other hand, immunomonitoring, diagnosis, prognosis and immunotherapeutic studies in cancer patients.

U932 retreat group photo

Key publications

Year of publication 2017

Christel Goudot, Alice Coillard, Alexandra-Chloé Villani, Paul Gueguen, Adeline Cros, Siranush Sarkizova, Tsing-Lee Tang-Huau, Mylène Bohec, Sylvain Baulande, Nir Hacohen, Sebastian Amigorena, Elodie Segura (2017 Sep 21)

Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages.

Immunity : 582-596.e6 : DOI : S1074-7613(17)30374-6
Mercedes Tkach, Joanna Kowal, Andres E Zucchetti, Lotte Enserink, Mabel Jouve, Danielle Lankar, Michael Saitakis, Lorena Martin-Jaular, Clotilde Théry (2017 Sep 20)

Qualitative differences in T-cell activation by dendritic cell-derived extracellular vesicle subtypes.

The EMBO journal : DOI : e201696003
SILVIN Aymeric, YU Chun, LAHAYE Xavier, IMPERATORE Francesco, BRAULT Jean-Baptiste, CARDINAUD Sylvain, BECKER Christian, KWAN Wing-Hong, CONRAD Cécile, MAURIN Mathieu, GOUDOT Christel, MARQUES-LADEIRA Santy, WANG Yuanyuan, PASCUAL Virginia, ANGUIANO Esperanza, ALBRECHT Randy, IANNACONE Matteo, GARCÍA-SASTRE Adolfo, GOUD Bruno, DALOD Marc, MORIS Arnaud, MERAD Miriam, PALUCKA Karolina, MANEL Nicolas (2017 Jul 7)

Constitutive resistance to viral infection in human CD141+ dendritic cells

Science Immunology : DOI : 10.1126/sciimmunol.aai8071
Andrés Alloatti, Derek C Rookhuizen, Leonel Joannas, Jean-Marie Carpier, Salvador Iborra, Joao G Magalhaes, Nader Yatim, Patrycja Kozik, David Sancho, Matthew L Albert, Sebastian Amigorena (2017 Jul 1)

Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity.

The Journal of experimental medicine : 2231-2241 : DOI : 10.1084/jem.20170229
Michael Saitakis, Stéphanie Dogniaux, Christel Goudot, Nathalie Bufi, Sophie Asnacios, Mathieu Maurin, Clotilde Randriamampita, Atef Asnacios, Claire Hivroz (2017 Jun 9)

Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity.

eLife : DOI : 10.7554/eLife.23190
Jérémie Decalf, Marion Desdouits, Vasco Rodrigues, François-Xavier Gobert, Matteo Gentili, Santy Marques-Ladeira, Célia Chamontin, Marylène Mougel, Bruna Cunha de Alencar, Philippe Benaroch (2017 May 12)

Sensing of HIV-1 Entry Triggers a Type I Interferon Response in Human Primary Macrophages.

Journal of virology : DOI : e00147-17