U932 – Immunity and Cancer

Teams in this unit work to better understand the immunological responses to tumours, and to learn how to use the immune system to fight cancer.

Research projects range from analysis of the most fundamental aspects of intracellular transport in cells of the immune system to functional aspects of immune responses to tumours in animal models and to clinical immunotherapy in cancer patients. Approaches include, on one hand molecular biology, biochemistry and imaging techniques, based on both in vitro and in vivo experimental models, and on the other hand, immunomonitoring, diagnosis, prognosis and immunotherapeutic studies in cancer patients.

U932 retreat group photo

Key publications

Year of publication 2020

Bellesoeur A1, Torossian N2, Amigorena S3, Romano E4. (2020 May 24)

Advances in theranostic biomarkers for tumor immunotherapy.

Cuurent opinion in chemical biology : 24;56 : DOI: 10.1016/j.cbpa.2020.02.005 : 79-90 : DOI : 10.1016/j.cbpa.2020.02.005
Erra Díaz F1, Ochoa V1, Merlotti A2, Dantas E1, Mazzitelli I1, Gonzalez Polo V1, Sabatté J1, Amigorena S2, Segura E2, Geffner J3. (2020 May 16)

Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic Cells.

Cell reports : 31(5) : DOI : 10.1016/j.celrep.2020.107613
Partula V1,2, Deschasaux M1, Druesne-Pecollo N1, Latino-Martel P1, Desmetz E1, Chazelas E1, Kesse-Guyot E1, Julia C1,3, Fezeu LK1, Galan P1, Hercberg S1,3, Mondot S4, Lantz O5,6, Quintana-Murci L7, Albert ML8, Duffy D9; Milieu Intérieur Consortium, Srour B1, Touvier M1. (2020 May 5)

Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort.

The American Journal of Clinical Nutrition : DOI : 10.1093/ajcn/nqaa063
Villar J1, Segura E2. (2020 Apr 24)

Recent advances towards deciphering human dendritic cell development.

Moecular immunology : 122 : 109 - 115 : DOI : DOI: 10.1016/j.molimm.2020.04.004
Ye M1, Goudot C1, Hoyler T1, Lemoine B2, Amigorena S3, Zueva E3. (2020 Apr 7)

Specific subfamilies of transposable elements contribute to different domains of T lymphocyte enhancers.

Proceedings of the National Academy of Sciences : 117 (14) : doi: 10.1073/pnas.1912008117 : 7905-7916 : DOI : 10.1073/pnas.1912008117
Zablocki-Thomas L1, Menzies SA2, Lehner PJ2, Manel N1, Benaroch P1. (2020 Apr 4)

A genome-wide CRISPR screen identifies regulation factors of the TLR3 signalling pathway.

Innate immunology : DOI : 10.1177/1753425920915507