U932 – Immunity and Cancer

Teams in this unit work to better understand the immunological responses to tumours, and to learn how to use the immune system to fight cancer.

Research projects range from analysis of the most fundamental aspects of intracellular transport in cells of the immune system to functional aspects of immune responses to tumours in animal models and to clinical immunotherapy in cancer patients. Approaches include, on one hand molecular biology, biochemistry and imaging techniques, based on both in vitro and in vivo experimental models, and on the other hand, immunomonitoring, diagnosis, prognosis and immunotherapeutic studies in cancer patients.

U932 retreat group photo

Key publications

Year of publication 2019

Ruffin N1, Gea-Mallorquí E1, Brouiller F1, Jouve M2, Silvin A1,3, See P3, Dutertre CA3,4, Ginhoux F5, Benaroch P6. (2020 Mar 22)

Constitutive Siglec-1 expression confers susceptibility to HIV-1 infection of human dendritic cell precursors.

Proceedings of the National Academy of Sciences : 116 : Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21685-21693. doi: 10.1073/pnas.1911007116. Epub 2019 Oct 7. : 21685,21693 : DOI : 10.1073/pnas.1911007116

Year of publication 2020

Edwards-Jorquera SS1, Bosveld F2, Bellaïche YA2, Lennon-Duménil AM3, Glavic Á1. (2020 Mar 2)

Trpml controls actomyosin contractility and couples migration to phagocytosis in fly macrophages.

Journal of cell biology : 2 : J Cell Biol. 2020 Mar 2;219(3). pii: e201905228. doi: 10.1083/jcb.201905228. : DOI : 10.1083/jcb.201905228
Pace L1, Amigorena S2. (2020 Feb 14)

Epigenetics of T cell fate decision.

Current opinion in immunology : 63 : Curr Opin Immunol. 2020 Feb 14;63:43-50. doi: 10.1016/j.coi.2020.01.002. [Epub ahead of print] : 43,50 : DOI : 10.1016/j.coi.2020.01.002

Year of publication 2019

Manel N1, Di Santo JP2. (2020 Feb 2)

Editorial overview: Pillars of innate immunity: constantly learning and trying to remember. Manel N1,

Current opinion in immunology : 56 : DOI : 10.1016/j.coi.2019.03.002

Year of publication 2020

Johnson JS1, De Veaux N2, Rives AW2, Lahaye X3, Lucas SY4, Perot BP5, Luka M5, Garcia-Paredes V5, Amon LM4, Watters A2, Abdessalem G5, Aderem A6, Manel N3, Littman DR7, Bonneau R8, Ménager MM9. (2020 Jan 21)

A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV.

Cell reports : 30 : Cell Rep. 2020 Jan 21;30(3):914-931.e9. doi: 10.1016/j.celrep.2019.12.054. : 914,931 : DOI : 10.1016/j.celrep.2019.12.054

Year of publication 2019

Stankevicins L, Ecker N, Terriac E, Maiuri P, Schoppmeyer R, Vargas P, Lennon-Duménil AM, Piel M, Qu B, Hoth M, Kruse K, Lautenschläger F. (2020 Jan 14)

Deterministic actin waves as generators of cell polarization cues.

Proceedings of the National Academy of Sciences : 117 : Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):826-835. doi: 10.1073/pnas.1907845117. Epub 2019 Dec 27. : 826,835 : DOI : 10.1073/pnas.1907845117