U932 – Immunity and Cancer

Teams in this unit work to better understand the immunological responses to tumours, and to learn how to use the immune system to fight cancer.

Research projects range from analysis of the most fundamental aspects of intracellular transport in cells of the immune system to functional aspects of immune responses to tumours in animal models and to clinical immunotherapy in cancer patients. Approaches include, on one hand molecular biology, biochemistry and imaging techniques, based on both in vitro and in vivo experimental models, and on the other hand, immunomonitoring, diagnosis, prognosis and immunotherapeutic studies in cancer patients.

U932 retreat group photo

Key publications

Year of publication 2018

SAEZ-CIRION Asier, MANEL Nicolas (2018 Jan 12)

Immune Responses to Retroviruses

Annual Review of ImmunologyAnnual Review of Immunology : DOI : 10.1146/annurev-immunol-051116-052155

Year of publication 2017

Fernando P Canale, Maria C Ramello, Nicolas Núñez, Cintia L Araujo Furlan, Sabrina N Bossio, Melisa Gorosito Serrán, Jimena Tosello Boari, Andrés Del Castillo, Marta Ledesma, Christine Sedlik, Eliane Piaggio, Adriana Gruppi, Eva V Acosta Rodríguez, Carolina L Montes (2017 Oct 26)

CD39 expression defines cell exhaustion in tumor-infiltrating CD8+ T cells.

Cancer research : DOI : canres.2684.2016
Sylvain Thierry, Wael Jdey, Solana Alculumbre, Vassili Soumelis, Patricia Noguiez-Hellin, Marie Dutreix (2017 Sep 27)

The DNA repair inhibitor Dbait is specific for malignant hematologic cells in blood.

Molecular cancer therapeutics : DOI : molcanther.0405.2017
Christel Goudot, Alice Coillard, Alexandra-Chloé Villani, Paul Gueguen, Adeline Cros, Siranush Sarkizova, Tsing-Lee Tang-Huau, Mylène Bohec, Sylvain Baulande, Nir Hacohen, Sebastian Amigorena, Elodie Segura (2017 Sep 21)

Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages.

Immunity : 582-596.e6 : DOI : S1074-7613(17)30374-6
Mercedes Tkach, Joanna Kowal, Andres E Zucchetti, Lotte Enserink, Mabel Jouve, Danielle Lankar, Michael Saitakis, Lorena Martin-Jaular, Clotilde Théry (2017 Sep 20)

Qualitative differences in T-cell activation by dendritic cell-derived extracellular vesicle subtypes.

The EMBO journal : DOI : e201696003
SILVIN Aymeric, YU Chun, LAHAYE Xavier, IMPERATORE Francesco, BRAULT Jean-Baptiste, CARDINAUD Sylvain, BECKER Christian, KWAN Wing-Hong, CONRAD Cécile, MAURIN Mathieu, GOUDOT Christel, MARQUES-LADEIRA Santy, WANG Yuanyuan, PASCUAL Virginia, ANGUIANO Esperanza, ALBRECHT Randy, IANNACONE Matteo, GARCÍA-SASTRE Adolfo, GOUD Bruno, DALOD Marc, MORIS Arnaud, MERAD Miriam, PALUCKA Karolina, MANEL Nicolas (2017 Jul 7)

Constitutive resistance to viral infection in human CD141+ dendritic cells

Science Immunology : DOI : 10.1126/sciimmunol.aai8071