U932 – Immunity and Cancer

Created in 2005, the INSERM U932 Unit is composed of 9 teams, spread over two buildings (Hôpital Curie and Constant-Burg building, rue Lhomond), with a total of about 120 people.

The teams of our department try to better understand the immune responses, and to direct the immune system to better fight against pathogens and/or tumours. Research projects range from fundamental immunology to translationnal immunology and cancer immunotherapy. These approaches include biology, biochemistry and molecular imaging techniques, based on both in vitro and in vivo experimental models, and immunological monitoring, diagnosis, prognosis and immunotherapy studies in cancer patients.

  • Immune responses and cancer (S. AMIGORENA)
  • Myeloid cells and immunity (P. BENAROCH)
  • Integrative analysis of T cell activation (C. HIVROZ)
  • Innate like and CD4+ T cells in cancer (O. LANTZ)
  • Spatio-temporal dynamics of immune cells (A.M. LENNON)
  • Innate immunity (N. MANEL)
  • Translational immunotherapy (E. PIAGGIO)
  • Stroma and immunity (H. SALMON)
  • Extracellular vesicles, immune responses and cancer (C. THERY)

Key publications

Year of publication 2021

Lorena Martin-Jaular, Nathalie Nevo, Julia P Schessner, Mercedes Tkach, Mabel Jouve, Florent Dingli, Damarys Loew, Kenneth W Witwer, Matias Ostrowski, Georg H H Borner, Clotilde Théry (2021 Mar 12)

Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.

The EMBO journal : e105492 : DOI : 10.15252/embj.2020105492

Year of publication 2020

Federico Cocozza, Nathalie Névo, Ester Piovesana, Xavier Lahaye, Julian Buchrieser, Olivier Schwartz, Nicolas Manel, Mercedes Tkach, Clotilde Théry, Lorena Martin-Jaular (2020 Dec 28)

Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus.

Journal of extracellular vesicles : e12050 : DOI : 10.1002/jev2.12050
A J Lomakin, C J Cattin, D Cuvelier, Z Alraies, M Molina, G P F Nader, N Srivastava, P J Sáez, J M Garcia-Arcos, I Y Zhitnyak, A Bhargava, M K Driscoll, E S Welf, R Fiolka, R J Petrie, N S De Silva, J M González-Granado, N Manel, A M Lennon-Duménil, D J Müller, M Piel (2020 Oct 16)

The nucleus acts as a ruler tailoring cell responses to spatial constraints.

Science (New York, N.Y.) : DOI : eaba2894
François Legoux, Marion Salou, Olivier Lantz (2020 Oct 14)

MAIT Cell Development and Functions: the Microbial Connection.

Immunity : 710-723 : DOI : S1074-7613(20)30403-9
Aleksandra S Chikina, Francesca Nadalin, Mathieu Maurin, Mabel San-Roman, Thibault Thomas-Bonafos, Xin V Li, Sonia Lameiras, Sylvain Baulande, Sandrine Henri, Bernard Malissen, Livia Lacerda Mariano, Jorge Barbazan, J Magarian Blander, Iliyan D Iliev, Danijela Matic Vignjevic, Ana-Maria Lennon-Duménil (2020 Sep 24)

Macrophages Maintain Epithelium Integrity by Limiting Fungal Product Absorption.

Cell : 411-428.e16 : DOI : S0092-8674(20)31090-4
Marianne Burbage, Sebastian Amigorena (2020 Aug 14)

A dendritic cell multitasks to tackle cancer.

Nature : 533-534 : DOI : 10.1038/d41586-020-02339-9