U932 – Immunity and Cancer

Teams in this unit work to better understand the immunological responses to tumours, and to learn how to use the immune system to fight cancer.

Research projects range from analysis of the most fundamental aspects of intracellular transport in cells of the immune system to functional aspects of immune responses to tumours in animal models and to clinical immunotherapy in cancer patients. Approaches include, on one hand molecular biology, biochemistry and imaging techniques, based on both in vitro and in vivo experimental models, and on the other hand, immunomonitoring, diagnosis, prognosis and immunotherapeutic studies in cancer patients.

Key publications

Year of publication 2016

Matteo Gentili, Nicolas Manel (2016 Mar 25)

cGAS-STING do it again: pivotal role in RNase H2 genetic disease.

The EMBO journal : DOI : e201694226
Dorian Obino, Francesca Farina, Odile Malbec, Pablo J Sáez, Mathieu Maurin, Jérémie Gaillard, Florent Dingli, Damarys Loew, Alexis Gautreau, Maria-Isabel Yuseff, Laurent Blanchoin, Manuel Théry, Ana-Maria Lennon-Duménil (2016 Mar 19)

Actin nucleation at the centrosome controls lymphocyte polarity

Nature communications : 10969 : DOI : 10.1038/ncomms10969
Joanna Kowal, Guillaume Arras, Marina Colombo, Mabel Jouve, Jakob Paul Morath, Bjarke Primdal-Bengtson, Florent Dingli, Damarys Loew, Mercedes Tkach, Clotilde Théry (2016 Feb 8)

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes.

PNAS : 113: E968-977 : DOI : 10.1073/pnas.1521230113

Year of publication 2015

Alloatti A1, Kotsias F2, Pauwels AM3, Carpier JM, Jouve M, Timmerman E, Pace L, Vargas P, Maurin M, Gehrmann U, Joannas L, Vivar OI, Lennon-Duménil AM, Savina A, Gevaert K, Beyaert R, Hoffmann E, Amigorena S. (2015 Dec 15)

Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens.

Immunity : DOI : 10.1016/j.immuni.2015.11.006
Pablo Vargas, Paolo Maiuri, Marine Bretou, Pablo J Sáez, Paolo Pierobon, Mathieu Maurin, Mélanie Chabaud, Danielle Lankar, Dorian Obino, Emmanuel Terriac, Matthew Raab, Hawa-Racine Thiam, Thomas Brocker, Susan M Kitchen-Goosen, Arthur S Alberts, Praveen Sunareni, Sheng Xia, Rong Li, Raphael Voituriez, Matthieu Piel, Ana-Maria Lennon-Duménil (2015 Dec 8)

Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells

Nature cell biology : 43-53 : DOI : 10.1038/ncb3284
Louis Pérol, Eliane Piaggio (2015 Nov 5)

New Molecular and Cellular Mechanisms of Tolerance: Tolerogenic Actions of IL-2.

Methods in molecular biology (Clifton, N.J.) : 11-28 : DOI : 10.1007/978-1-4939-3139-2_2