U932 – Immunity and Cancer

Teams in this unit work to better understand the immunological responses to tumours, and to learn how to use the immune system to fight cancer.

Research projects range from analysis of the most fundamental aspects of intracellular transport in cells of the immune system to functional aspects of immune responses to tumours in animal models and to clinical immunotherapy in cancer patients. Approaches include, on one hand molecular biology, biochemistry and imaging techniques, based on both in vitro and in vivo experimental models, and on the other hand, immunomonitoring, diagnosis, prognosis and immunotherapeutic studies in cancer patients.

U932 retreat group photo

Key publications

Year of publication 2019

François Legoux, Déborah Bellet, Celine Daviaud, Yara El Morr, Aurelie Darbois, Kristina Niort, Emanuele Procopio, Marion Salou, Jules Gilet, Bernhard Ryffel, Aurélie Balvay, Anne Foussier, Manal Sarkis, Ahmed El Marjou, Frederic Schmidt, Sylvie Rabot, Olivier Lantz (2019 Aug 31)

Microbial metabolites control the thymic development of mucosal-associated invariant T cells.

Science (New York, N.Y.) : DOI : eaaw2719
François Legoux, Jules Gilet, Emanuele Procopio, Klara Echasserieau, Karine Bernardeau, Olivier Lantz (2019 Aug 22)

Molecular mechanisms of lineage decisions in metabolite-specific T cells.

Nature immunology : 1244-1255 : DOI : 10.1038/s41590-019-0465-3
Andres Ernesto Zucchetti, Laurence Bataille, Jean-Marie Carpier, Stéphanie Dogniaux, Mabel San Roman-Jouve, Mathieu Maurin, Michael W Stuck, Rosa M Rios, Cosima T Baldari, Gregory J Pazour, Claire Hivroz (2019 Jun 30)

Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse.

Nature communications : 2864 : DOI : 10.1038/s41467-019-10891-w
Anita Kumari, Judith Pineau, Pablo J Sáez, Mathieu Maurin, Danielle Lankar, Mabel San Roman, Katharina Hennig, Vanessa F Boura, Raphael Voituriez, Mikael C I Karlsson, Martial Balland, Ana-Maria Lennon Dumenil, Paolo Pierobon (2019 Jun 30)

Actomyosin-driven force patterning controls endocytosis at the immune synapse.

Nature communications : 2870 : DOI : 10.1038/s41467-019-10751-7
Olivier Lantz, François Legoux (2019 May 30)

MAIT cells: programmed in the thymus to mediate immunity within tissues.

Current opinion in immunology : 75-82 : DOI : S0952-7915(18)30079-7
Mélanie Durand, Thomas Walter, Tiphène Pirnay, Thomas Naessens, Paul Gueguen, Christel Goudot, Sonia Lameiras, Qing Chang, Nafiseh Talaei, Olga Ornatsky, Tatiana Vassilevskaia, Sylvain Baulande, Sebastian Amigorena, Elodie Segura (2019 May 11)

Human lymphoid organ cDC2 and macrophages play complementary roles in T follicular helper responses.

The Journal of experimental medicine : DOI : jem.20181994