Stress and Cancer

Team Members

Fatima Mechta-Grigoriou, PhD

Fatima Mechta-Grigoriou

Fatima Mechta-Grigoriou Team Leader Team Mechta-Grigoriou Unit Deputy Director Stress and cancer Tel:

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Key publications

Year of publication 2019

G Gentric, Y Kieffer, V Mieulet, O Goundiam, C Bonneau, F Nemati, I Hurbain, G Raposo, T Popova, MH Stern, V Lallemand-Breitenbach, S Müller, T Cañeque, R Rodriguez, A Vincent-Salomon, H de Thé, R Rossignol, F Mechta-Grigoriou (2019 Jan 5)

PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers

Cell Metabolism

Year of publication 2018

Givel AM, Kieffer Y, Scholer-Dahirel A, Sirven P, Cardon M, Pelon F, Magagna I, Gentric G, Costa A, Bonneau C, Mieulet V, Vincent-Salomon A, Mechta-Grigoriou F (2018 Mar 13)

miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers.

Nature communications : DOI : 10.1038/s41467-018-03348-z.
Costa A, Kieffer Y, Scholer-Dahirel A, Pelon F, Bourachot B, Cardon M, Sirven P, Magagna I, Fuhrmann L, Bernard C, Bonneau C, Kondratova M, Kuperstein I, Zinovyev A, Givel AM, Parrini MC, Soumelis V, Vincent-Salomon A, Mechta-Grigoriou F (2018 Mar 12)

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer.

Cancer Cell : 463-479 : DOI : 10.1016/j.ccell.2018.01.011
Costa, A., Kieffer, Y., Scholer-Dahirel, A., Pelon, F., Bourachot, B., Cardon, M., Sirven, P., Magagna, I., Fuhrmann, L., Bernard, C., Bonneau, C., Kondratova, M., Kuperstein, I., Zinovyev, A., Givel, A.-M., Parrini, M.-C., Soumelis, V., Vincent-Salomon, A., and Mechta-Grigoriou, F (2018 Mar 12)

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

Cancer Cell : 33 : 463,479 : DOI : doi.org/10.1016/j.ccell.2018.01.011

Year of publication 2017

Gentric G, Mieulet V, Mechta-Grigoriou F (2017 Mar 20)

Heterogeneity in Cancer Metabolism: New Concepts in an Old Field.

Antioxidants & Redox Signaling : 26 : DOI : 10.1089/ars.2016.6750
Lefort, A Thuleau, Y Kieffer, P Sirven, I Bieche, E Marangoni, A Vincent-Salomon & F Mechta-Grigoriou (2017 Mar 2)

CXCR4 inhibitors could benefit to HER2 but not to triple-negative breast cancer patients

Oncogene : 1211–1222 : DOI : 10.1038

Year of publication 2016

Tina Gruosso, Virginie Mieulet, Melissa Cardon, Brigitte Bourachot, Yann Kieffer, Flavien Devun, Thierry Dubois, Marie Dutreix, Anne Vincent-Salomon, Kyle Malcolm Miller, Fatima Mechta-Grigoriou (2016 Mar 24)

Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients.

EMBO molecular medicine : 527-49 : DOI : 10.15252/emmm.201505891
Luciana Batista, Brigitte Bourachot, Bogdan Mateescu, Fabien Reyal, Fatima Mechta-Grigoriou (2016 Jan 5)

Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through.

Nature communications : 8959 : DOI : 10.1038/ncomms9959

Year of publication 2015

Tina Gruosso, Camille Garnier, Sophie Abelanet, Yann Kieffer, Vincent Lemesre, Dorine Bellanger, Ivan Bieche, Elisabetta Marangoni, Xavier Sastre-Garau, Virginie Mieulet, Fatima Mechta-Grigoriou (2015 Oct 13)

MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas.

Nature communications : 8583 : DOI : 10.1038/ncomms9583