Bioinformatics and Computational Systems Biology of Cancer

Team Members

Emmanuel Barillot, PhD

Emmanuel arillot

Emmanuel Barillot Chef d'équipe Team Barillot Unit Director Team Leader Tel: Back to the list

Key publications

Year of publication 2017

Boeva, V., Louis-Brennetot, C., Peltier, A., Durand, S., Pierre-Eugène, C., Raynal, V., Etchevers, H.C., Thomas, S., Lermine, A., Daudigeos-Dubus, E., Geoerger, B., Orth, M.F., Grünewald, T.G.P., Diaz, E., Ducos, B., Surdez, D., Carcaboso, A.M., Medvedeva, I., Deller, T., Combaret, V., Lapouble, E., Pierron, G., Grossetête-Lalami, S., Baulande, S., Schleiermacher, G., Barillot, E., Rohrer, H., Delattre, O., and Janoueix-Lerosey, I. (2017 Sep 1)

Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries.

Nature Genetics : DOI : 10.1038/ng.3921
Maud Borensztein, Laurène Syx, Katia Ancelin, Patricia Diabangouaya, Christel Picard, Tao Liu, Jun-Bin Liang, Ivaylo Vassilev, Rafael Galupa, Nicolas Servant, Emmanuel Barillot, Azim Surani, Chong-Jian Chen, Edith Heard (2017 Jan 31)

Xist-dependent imprinted X inactivation and the early developmental consequences of its failure.

Nature structural & molecular biology : DOI : 10.1038/nsmb.3365

Year of publication 2016

Wael Jdey, Sylvain Thierry, Christophe Russo, Flavien Devun, Muthana Al Abo, Patricia Noguiez-Hellin, Jian-Sheng Sun, Emmanuel Barillot, Andrei Zinovyev, Inna Kuperstein, Yves Pommier, Marie Dutreix (2016 Aug 26)

Drug Driven Synthetic Lethality: bypassing tumor cell genetics with a combination of Dbait and PARP inhibitors.

Clinical cancer research : an official journal of the American Association for Cancer Research : DOI : clincanres.1193.2016

Year of publication 2015

Antonio Cappuccio, Raphaël Zollinger, Mirjam Schenk, Aleksandra Walczak, Nicolas Servant, Emmanuel Barillot, Philippe Hupé, Robert L Modlin, Vassili Soumelis (2015 Apr 21)

Combinatorial code governing cellular responses to complex stimuli.

Nature communications : 6847 : DOI : 10.1038/ncomms7847

Year of publication 2014

Maia Chanrion, Inna Kuperstein, Cédric Barrière, Fatima El Marjou, David Cohen, Danijela Vignjevic, Lev Stimmer, Perrine Paul-Gilloteaux, Ivan Bièche, Silvina Dos Reis Tavares, Giuseppe-Fulvio Boccia, Wulfran Cacheux, Didier Meseure, Silvia Fre, Loredana Martignetti, Patricia Legoix-Né, Elodie Girard, Luc Fetler, Emmanuel Barillot, Daniel Louvard, Andreï Zinovyev, Sylvie Robine (2014 Apr 9)

Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut.

Nature communications : 5005 : DOI : 10.1038/ncomms6005
Anne Biton, Isabelle Bernard-Pierrot, Yinjun Lou, Clémentine Krucker, Elodie Chapeaublanc, Carlota Rubio-Pérez, Nuria López-Bigas, Aurélie Kamoun, Yann Neuzillet, Pierre Gestraud, Luca Grieco, Sandra Rebouissou, Aurélien de Reyniès, Simone Benhamou, Thierry Lebret, Jennifer Southgate, Emmanuel Barillot, Yves Allory, Andrei Zinovyev, François Radvanyi (2014 Jan 25)

Independent component analysis uncovers the landscape of the bladder tumor transcriptome and reveals insights into luminal and basal subtypes.

Cell reports : 1235-45 : DOI : 10.1016/j.celrep.2014.10.035

Year of publication 2013

Andrei Zinovyev, Inna Kuperstein, Emmanuel Barillot, Wolf-Dietrich Heyer (2013 Dec 14)

Synthetic lethality between gene defects affecting a single non-essential molecular pathway with reversible steps.

PLoS computational biology : e1003016 : DOI : 10.1371/journal.pcbi.1003016
Haitham Ashoor, Aurélie Hérault, Aurélie Kamoun, François Radvanyi, Vladimir B Bajic, Emmanuel Barillot, Valentina Boeva (2013 Sep 9)

HMCan: a method for detecting chromatin modifications in cancer samples using ChIP-seq data.

Bioinformatics (Oxford, England) : 2979-86 : DOI : 10.1093/bioinformatics/btt524
Virginie Maire, Céline Baldeyron, Marion Richardson, Bruno Tesson, Anne Vincent-Salomon, Eléonore Gravier, Bérengère Marty-Prouvost, Leanne De Koning, Guillem Rigaill, Aurélie Dumont, David Gentien, Emmanuel Barillot, Sergio Roman-Roman, Stéphane Depil, Francisco Cruzalegui, Alain Pierré, Gordon C Tucker, Thierry Dubois (2013 May 24)

TTK/hMPS1 is an attractive therapeutic target for triple-negative breast cancer.

PloS one : e63712 : DOI : 10.1371/journal.pone.0063712

Year of publication 2012

Virginie Maire, Fariba Némati, Marion Richardson, Anne Vincent-Salomon, Bruno Tesson, Guillem Rigaill, Eléonore Gravier, Bérengère Marty-Prouvost, Leanne De Koning, Guillaume Lang, David Gentien, Aurélie Dumont, Emmanuel Barillot, Elisabetta Marangoni, Didier Decaudin, Sergio Roman-Roman, Alain Pierré, Francisco Cruzalegui, Stéphane Depil, Gordon C Tucker, Thierry Dubois (2012 Nov 13)

Polo-like kinase 1: a potential therapeutic option in combination with conventional chemotherapy for the management of patients with triple-negative breast cancer.

Cancer research : 813-23 : DOI : 10.1158/0008-5472.CAN-12-2633
Eric Bonnet, Laurence Calzone, Daniel Rovera, Gautier Stoll, Emmanuel Barillot, Andrei Zinovyev (2012 Sep 7)

BiNoM 2.0, a Cytoscape plugin for accessing and analyzing pathways using standard systems biology formats.

BMC systems biology : 18 : DOI : 10.1186/1752-0509-7-18
Sofia I Bogiatzi, Maude Guillot-Delost, Antonio Cappuccio, Jean-Christophe Bichet, Olfa Chouchane-Mlik, Marie-Hélène Donnadieu, Emmanuel Barillot, Philippe Hupé, Katerina Chlichlia, Eleni I Efremidou, Selim Aractingi, Olivier Bayrou, Vassili Soumelis (2012 Mar 11)

Multiple-checkpoint inhibition of thymic stromal lymphopoietin-induced TH2 response by TH17-related cytokines.

The Journal of allergy and clinical immunology : 233-40.e5 : DOI : 10.1016/j.jaci.2012.04.038

Year of publication 2011

Elphège P Nora, Bryan R Lajoie, Edda G Schulz, Luca Giorgetti, Ikuhiro Okamoto, Nicolas Servant, Tristan Piolot, Nynke L van Berkum, Johannes Meisig, John Sedat, Joost Gribnau, Emmanuel Barillot, Nils Blüthgen, Job Dekker, Edith Heard (2011 Oct 3)

Spatial partitioning of the regulatory landscape of the X-inactivation centre.

Nature : 381-5 : DOI : 10.1038/nature11049

Year of publication 2009

Laurence Calzone, Laurent Tournier, Simon Fourquet, Denis Thieffry, Boris Zhivotovsky, Emmanuel Barillot, Andrei Zinovyev (2009 Aug 25)

Mathematical modelling of cell-fate decision in response to death receptor engagement.

PLoS computational biology : e1000702 : DOI : 10.1371/journal.pcbi.1000702
Elisabetta Volpe, Maxime Touzot, Nicolas Servant, Marie-Annick Marloie-Provost, Philippe Hupé, Emmanuel Barillot, Vassili Soumelis (2009 Aug 24)

Multiparametric analysis of cytokine-driven human Th17 differentiation reveals a differential regulation of IL-17 and IL-22 production.

Blood : 3610-4 : DOI : 10.1182/blood-2009-05-223768
Jennifer C Chow, Constance Ciaudo, Melissa J Fazzari, Nathan Mise, Nicolas Servant, Jacob L Glass, Matthew Attreed, Philip Avner, Anton Wutz, Emmanuel Barillot, John M Greally, Olivier Voinnet, Edith Heard (2009 Aug 21)

LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation.

Cell : 956-69 : DOI : 10.1016/j.cell.2010.04.042

Year of publication 2008

Bérengère Marty, Virginie Maire, Eléonore Gravier, Guillem Rigaill, Anne Vincent-Salomon, Marion Kappler, Ingrid Lebigot, Fathia Djelti, Audrey Tourdès, Pierre Gestraud, Philippe Hupé, Emmanuel Barillot, Francisco Cruzalegui, Gordon C Tucker, Marc-Henri Stern, Jean-Paul Thiery, John A Hickman, Thierry Dubois (2008 Dec 6)

Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells.

Breast cancer research : BCR : R101 : DOI : 10.1186/bcr2204