DNA Recombination, Replication and Genome Stability

Team Members

Sarah Lambert, PhD

Sarah lambert

Sarah Lambert CNRS Research Director Team Lambert Team Leader Tel: Back to the list

Key publications

Year of publication 2017

Ana Teixeira-Silva, Anissia Ait Saada, Julien Hardy, Ismail Iraqui, Marina Charlotte Nocente, Karine Fréon, Sarah A E Lambert (2017 Dec 7)

The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks.

Nature communications : 1982 : DOI : 10.1038/s41467-017-02144-5
Anissia Ait Saada, Ana Teixeira-Silva, Ismail Iraqui, Audrey Costes, Julien Hardy, Giulia Paoletti, Karine Fréon, Sarah A E Lambert (2017 May 4)

Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges.

Molecular cell : 398-410.e4 : DOI : 10.1016/j.molcel.2017.04.002

Year of publication 2016

Simon Gemble, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Denis Biard, Sarah Lambert, Mounira Amor-Guéret (2016 Aug 15)

A balanced pyrimidine pool is required for optimal Chk1 activation to prevent ultrafine anaphase bridge formation.

Journal of cell science : 3167-77 : DOI : 10.1242/jcs.187781

Year of publication 2015

Simon Gemble, Akshay Ahuja, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Julien Dairou, Denis S F Biard, Sarah Lambert, Massimo Lopes, Mounira Amor-Guéret (2015 Jul 16)

Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.

PLoS genetics : e1005384 : DOI : 10.1371/journal.pgen.1005384

Year of publication 2014

Violena Pietrobon, Karine Fréon, Julien Hardy, Audrey Costes, Ismail Iraqui, Françoise Ochsenbein, Sarah A E Lambert (2014 Oct 14)

The chromatin assembly factor 1 promotes Rad51-dependent template switches at replication forks by counteracting D-loop disassembly by the RecQ-type helicase Rqh1.

PLoS biology : e1001968 : DOI : 10.1371/journal.pbio.1001968
Ellen Tsang, Izumi Miyabe, Ismail Iraqui, Jiping Zheng, Sarah A E Lambert, Antony M Carr (2014 Jul 1)

The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins.

Journal of cell science : 2983-94 : DOI : 10.1242/jcs.152678
Indiana Magdalou, Bernard S Lopez, Philippe Pasero, Sarah A E Lambert (2014 Jun 1)

The causes of replication stress and their consequences on genome stability and cell fate.

Seminars in cell & developmental biology : 154-64 : DOI : 10.1016/j.semcdb.2014.04.035
Martin Dutertre, Sarah Lambert, Aura Carreira, Mounira Amor-Guéret, Stéphan Vagner (2014 Mar 1)

DNA damage: RNA-binding proteins protect from near and far.

Trends in biochemical sciences : 141-9 : DOI : 10.1016/j.tibs.2014.01.003

Year of publication 2011

Pauline Chabosseau, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Sarah Lambert, Michelle Debatisse, Olivier Brison, Mounira Amor-Guéret (2011 Jun 28)

Pyrimidine pool imbalance induced by BLM helicase deficiency contributes to genetic instability in Bloom syndrome.

Nature communications : 368 : DOI : 10.1038/ncomms1363

Year of publication 2010

Sarah Lambert, Ken'ichi Mizuno, Joël Blaisonneau, Sylvain Martineau, Roland Chanet, Karine Fréon, Johanne M Murray, Antony M Carr, Giuseppe Baldacci (2010 Aug 13)

Homologous recombination restarts blocked replication forks at the expense of genome rearrangements by template exchange.

Molecular cell : 346-59 : DOI : 10.1016/j.molcel.2010.07.015