DNA Recombination, Replication and Genome Stability | Institut Curie

Team

SARAH LAMBERT

DNA Recombination, Replication and Genome Stability

During an average human life span, each individual copies several light-years of DNA to ensure organism development and tissue homeostasis. Flaws in the DNA replication process, known as replication stress, result in inaccurate chromosome duplication and subsequent mitotic abnormalities.

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Members

Deputy Director of Research Unit

MOUNIRA AMOR-GUERET

Researcher Emeritus

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VINCENT PENNANEACH

Permanent Researcher

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ANISSIA AIT SAADA

Post-Doctoral Researcher

KAZI FAIZUL AZIM

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SHRENA CHAKRABORTY

Past members

ANISSIA AIT-SAADA

PhD Student

CHARLOTTE AUDOYNAUD

PhD Student

VIRGINIE BOUCHERIT

Engineer

DINGLI DAI

PhD Student

LOUISE DUPOIRON

Engineer assistant

JULIEN HARDY

Post-Doctoral Researcher

MY-ANNE HONG

Engineer

KAROL KRAMARZ

Post-Doctoral Researcher

ANA CAROLINA TEIXEIRA DA SILVA

PhD Student

Our projects

Illustration projet 1 équipe Lambert

Nuclear positioning and replication fork repair pathways choice

Illustration projet 2 équipe Lambert

Replication fork repair and Chromatin assembly

Works

manipulation

Recombination-Dependent Replication

Key publications

2021

Recombination-dependent replication: new perspectives from site-specific fork barriers
Current Opinion in Genetics & Development

Antony Carr, Sarah Lambert
(2021 01 Dec)
2021

Non-homologous end-joining at challenged replication forks: an RNA connection?
Trends in Genetics

Charlotte Audoynaud, Stéphan Vagner, Sarah Lambert
(2021 01 Nov)
2021

The Analysis of Recombination-Dependent Processing of Blocked Replication Forks by Bidimensional Gel Electrophoresis
Homologous Recombination

Karol Kramarz, Anissia Ait Saada, Sarah A. E. Lambert
(2021 01 Jan)
2020

The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal
Nature Communications

Karol Kramarz, Kamila Schirmeisen, Virginie Boucherit, Anissia Ait Saada, Claire Lovo, Benoit Palancade, Catherine Freudenreich, Sarah A. E. Lambert
(2020 01 Dec)
2020

Topoisomerase IIα prevents ultrafine anaphase bridges by two mechanisms
Open Biology

Simon Gemble, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Gaëlle Fontaine, Sarah Lambert, Mounira Amor-Guéret
(2020 01 May)
2020

Des mécanismes moléculaires aux applications cliniques. L’essentiel du Colloque Réplication-Réparation-Recombinaison 2019
Bulletin du Cancer

Sarah Lambert, Valérie Borde, Jean-Baptiste Charbonnier, Françoise Dantzer, Olivier Espéli, Josée Guirouilh-Barbat, Bertrand Llorente, Gaëlle Legube, Marie-Noëlle Prioleau, Pablo Radicella
(2020 01 Feb)

All publications

News

New major players in the protection of DNA replication forks are identified

In an article published on March 2, 2023, in the journal Molecular Cell, the team led by Sarah Lambert, in collaboration with researchers from the Institute for Integrative Biology of the Cell, revealed a mechanism that ensures the integrity of DNA replication forks. Based on the combination of RNA and the end-joining factor Ku, it represents a potential new therapeutic target to fight cancerous cells.

13/03/2023

Job offers

No job offers available.

Partners

Fondation ARC

ANR

INCa

La Ligue contre le cancer