Regulation of microtubule dynamics and functions

Team Members

Carsten Janke, PhD

Carsten Janke

Carsten Janke CNRS Research Director Team Janke Team Leader Tel: Back to the list

1994: Diploma in Biochemistry, University of Leipzig, Germany
1998: PhD in Biochemistry-Neurochemistry, University of Leipzig, Germany
1998-1999: Postdoc in biophysics, CBM, CNRS Orléans, France
1999-2002: Postdoc in yeast cell biology, Beatson Institut for Cancer Research, Glasgow, UK
2002-2005: Postdoc & staff scientist (CR1), CRBM, CNRS Montpellier, France
2005-2010: Junior group leader, CRBM, CNRS Montpellier, France
2009: DR2 CNRS
2010 - today: Senior group leader at the Institut Curie, Orsay, France
2013: DR1 CNRS

Scientific achievements and prices

2008           EMBO Young Investigator
2014            EMBO member

Experience with network coordination and grant applications

  • Coordinator of 8 research grants (HFSP, ANR, INCA, …).
  • Co-funder and scientific coordinator of a European Initial Training Network (ITN)
  • 19 successful grant applications
  • 20 successful applications for fellowships in the Janke team.

Implications in the scientific community

  • Established a large number of scientific collaborations
  • Organizer of an EMBO conference series (2010, 2012, 2016), and an EMBL/EMBO symposium (2016) on Microtubules
  • Organizer of a French-Indian Cytoskeleton workshop (2015)
  • Reviewer for many grant agencies and scientific journals

Member for evaluation commissions, scientific advisory boards, editorial board of J Cell Science

Key publications

Year of publication 2018

Maria M Magiera, Satish Bodakuntla, Jakub Žiak, Sabrina Lacomme, Patricia Marques Sousa, Sophie Leboucher, Torben J Hausrat, Christophe Bosc, Annie Andrieux, Matthias Kneussel, Marc Landry, André Calas, Martin Balastik, Carsten Janke (2018 Nov 12)

Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport.

The EMBO journal. : DOI : e100440
Vandana Shashi, Maria M Magiera, Dennis Klein, Maha Zaki, Kelly Schoch, Sabine Rudnik-Schöneborn, Andrew Norman, Osorio Lopes Abath Neto, Marina Dusl, Xidi Yuan, Luca Bartesaghi, Patrizia De Marco, Ahmed A Alfares, Ronit Marom, Stefan T Arold, Francisco J Guzmán-Vega, Loren Dm Pena, Edward C Smith, Maja Steinlin, Mohamed Oe Babiker, Payam Mohassel, A Reghan Foley, Sandra Donkervoort, Rupleen Kaur, Partha S Ghosh, Valentina Stanley, Damir Musaev, Caroline Nava, Cyril Mignot, Boris Keren, Marcello Scala, Elisa Tassano, Paolo Picco, Paola Doneda, Chiara Fiorillo, Mahmoud Y Issa, Ali Alassiri, Ahmed Alahmad, Amanda Gerard, Pengfei Liu, Yaping Yang, Birgit Ertl-Wagner, Peter G Kranz, Ingrid M Wentzensen, Rolf Stucka, Nicholas Stong, Andrew S Allen, David B Goldstein, , Benedikt Schoser, Kai M Rösler, Majid Alfadhel, Valeria Capra, Roman Chrast, Tim M Strom, Erik-Jan Kamsteeg, Carsten G Bönnemann, Joseph G Gleeson, Rudolf Martini, Carsten Janke, Jan Senderek (2018 Nov 12)

Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration.

The EMBO journal. : DOI : e100540
Maria M Magiera, Puja Singh, Carsten Janke (2018 May 31)

SnapShot: Functions of Tubulin Posttranslational Modifications.

Cell : 1552-1552.e1 : DOI : 10.1016/j.cell.2018.05.032
Maria M Magiera, Puja Singh, Sudarshan Gadadhar, Carsten Janke (2018 May 31)

Tubulin Posttranslational Modifications and Emerging Links to Human Disease.

Cell : 1323-1327 : DOI : 10.1016/j.cell.2018.05.018
Renaud Chabrier, Carsten Janke (2018 Mar 1)

The comeback of hand drawing in modern life sciences.

Nature reviews. Molecular cell biology : DOI : 10.1038/nrm.2017.126

Year of publication 2017

Sudarshan Gadadhar, Hala Dadi, Satish Bodakuntla, Anne Schnitzler, Ivan Bièche, Filippo Rusconi, Carsten Janke (2017 Sep 4)

Tubulin glycylation controls primary cilia length.

The Journal of cell biology : 2701-2713 : DOI : 10.1083/jcb.201612050
Kathiresan Natarajan, Sudarshan Gadadhar, Judith Souphron, Maria M Magiera, Carsten Janke (2017 Jun 1)

Molecular interactions between tubulin tails and glutamylases reveal determinants of glutamylation patterns.

EMBO reports : 1013-1026 : DOI : 10.15252/embr.201643751
Montserrat Bosch Grau, Christel Masson, Sudarshan Gadadhar, Cecilia Rocha, Olivia Tort, Patricia Marques Sousa, Sophie Vacher, Ivan Bieche, Carsten Janke (2017 Mar 1)

Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration.

Journal of cell science : DOI : 10.1242/jcs.199091

Year of publication 2016

Jeffrey J Nirschl, Maria M Magiera, Jacob E Lazarus, Carsten Janke, Erika L F Holzbaur (2016 Mar 22)

α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons.

Cell reports : 2637-52 : DOI : 10.1016/j.celrep.2016.02.046

Year of publication 2015

Marin Barisic, Ricardo Silva e Sousa, Suvranta K Tripathy, Maria M Magiera, Anatoly V Zaytsev, Ana L Pereira, Carsten Janke, Ekaterina L Grishchuk, Helder Maiato (2015 May 15)

Mitosis. Microtubule detyrosination guides chromosomes during mitosis.

Science (New York, N.Y.) : 799-803 : DOI : 10.1126/science.aaa5175

Year of publication 2014

Olivia Tort, Sebastián Tanco, Cecilia Rocha, Ivan Bièche, Cecilia Seixas, Christophe Bosc, Annie Andrieux, Marie-Jo Moutin, Francesc Xavier Avilés, Julia Lorenzo, Carsten Janke (2014 Oct 1)

The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids.

Molecular biology of the cell : 3017-27 : DOI : 10.1091/mbc.E14-06-1072
Cecilia Rocha, Laura Papon, Wulfran Cacheux, Patricia Marques Sousa, Valeria Lascano, Olivia Tort, Tiziana Giordano, Sophie Vacher, Benedicte Lemmers, Pascale Mariani, Didier Meseure, Jan Paul Medema, Ivan Bièche, Michael Hahne, Carsten Janke (2014 Oct 1)

Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon.

The EMBO journal : 2247-60 : DOI : 10.15252/embj.201488466

Year of publication 2011

Carsten Janke, Jeannette Chloë Bulinski (2011 Nov 16)

Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions.

Nature reviews. Molecular cell biology : 773-86 : DOI : 10.1038/nrm3227

Year of publication 2010

Krzysztof Rogowski, Juliette van Dijk, Maria M Magiera, Christophe Bosc, Jean-Christophe Deloulme, Anouk Bosson, Leticia Peris, Nicholas D Gold, Benjamin Lacroix, Montserrat Bosch Grau, Nicole Bec, Christian Larroque, Solange Desagher, Max Holzer, Annie Andrieux, Marie-Jo Moutin, Carsten Janke (2010 Nov 12)

A family of protein-deglutamylating enzymes associated with neurodegeneration.

Cell : 564-78 : DOI : 10.1016/j.cell.2010.10.014
Benjamin Lacroix, Juliette van Dijk, Nicholas D Gold, Julien Guizetti, Gudrun Aldrian-Herrada, Krzysztof Rogowski, Daniel W Gerlich, Carsten Janke (2010 Jun 14)

Tubulin polyglutamylation stimulates spastin-mediated microtubule severing.

The Journal of cell biology : 945-54 : DOI : 10.1083/jcb.201001024

Year of publication 2009

Krzysztof Rogowski, François Juge, Juliette van Dijk, Dorota Wloga, Jean-Marc Strub, Nicolette Levilliers, Daniel Thomas, Marie-Hélène Bré, Alain Van Dorsselaer, Jacek Gaertig, Carsten Janke (2009 Jun 12)

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.

Cell : 1076-87 : DOI : 10.1016/j.cell.2009.05.020

Year of publication 2007

Juliette van Dijk, Krzysztof Rogowski, Julie Miro, Benjamin Lacroix, Bernard Eddé, Carsten Janke (2007 May 11)

A targeted multienzyme mechanism for selective microtubule polyglutamylation.

Molecular cell : 437-48 : DOI : 10.1016/j.molcel.2007.04.012

Year of publication 2005

Carsten Janke, Krzysztof Rogowski, Dorota Wloga, Catherine Regnard, Andrey V Kajava, Jean-Marc Strub, Nevzat Temurak, Juliette van Dijk, Dominique Boucher, Alain van Dorsselaer, Swati Suryavanshi, Jacek Gaertig, Bernard Eddé (2005 Jun 17)

Tubulin polyglutamylase enzymes are members of the TTL domain protein family.

Science (New York, N.Y.) : 1758-62 : DOI : 10.1126/science.1113010