Controlling Microtubule Dynamics and Function with the tubulin code

Team Members

Carsten Janke, PhD

Carsten Janke

Carsten Janke CNRS Research Director Team Janke Team Leader Tel: Back to the list

1994: Diploma in Biochemistry, University of Leipzig, Germany
1998: PhD in Biochemistry-Neurochemistry, University of Leipzig, Germany
1998-1999: Postdoc in biophysics, CBM, CNRS Orléans, France
1999-2002: Postdoc in yeast cell biology, Beatson Institut for Cancer Research, Glasgow, UK
2002-2005: Postdoc & staff scientist (CR1), CRBM, CNRS Montpellier, France
2005-2010: Junior group leader, CRBM, CNRS Montpellier, France
2009: DR2 CNRS
2010 - today: Senior group leader at the Institut Curie, Orsay, France
2013: DR1 CNRS

Scientific achievements and prices

2008           EMBO Young Investigator
2014            EMBO member

Experience with network coordination and grant applications

  • Coordinator of 8 research grants (HFSP, ANR, INCA, …).
  • Co-funder and scientific coordinator of a European Initial Training Network (ITN)
  • 19 successful grant applications
  • 20 successful applications for fellowships in the Janke team.

Implications in the scientific community

  • Established a large number of scientific collaborations
  • Organizer of an EMBO conference series (2010, 2012, 2016), and an EMBL/EMBO symposium (2016) on Microtubules
  • Organizer of a French-Indian Cytoskeleton workshop (2015)
  • Reviewer for many grant agencies and scientific journals

Member for evaluation commissions, scientific advisory boards, editorial board of J Cell Science

Key publications

Year of publication 2021

Sudarshan Gadadhar, Gonzalo Alvarez Viar, Jan Niklas Hansen, An Gong, Aleksandr Kostarev, Côme Ialy-Radio, Sophie Leboucher, Marjorie Whitfield, Ahmed Ziyyat, Aminata Touré, Luis Alvarez, Gaia Pigino , Carsten Janke (2021 Jan 8)

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility

ScienceScience : DOI : 10.1126/science.abd4914

Year of publication 2020

Carsten Janke, Maria M Magiera (2020 Feb 27)

The tubulin code and its role in controlling microtubule properties and functions.

Nature reviews. Molecular cell biology : DOI : 10.1038/s41580-020-0214-3

Year of publication 2019

Satish Bodakuntla, A S Jijumon, Cristopher Villablanca, Christian Gonzalez-Billault, Carsten Janke (2019 Oct 29)

Microtubule-Associated Proteins: Structuring the Cytoskeleton.

Trends in cell biology : 804-819 : DOI : S0962-8924(19)30120-5
Tiziana Giordano, Sudarshan Gadadhar, Satish Bodakuntla, Jonas Straub, Sophie Leboucher, Guillaume Martinez, Walid Chemlali, Christophe Bosc, Annie Andrieux, Ivan Bieche, Christophe Arnoult, Stefan Geimer, Carsten Janke (2019 Feb 7)

Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility.

Journal of cell science : DOI : jcs226951

Year of publication 2018

Maria M Magiera, Satish Bodakuntla, Jakub Žiak, Sabrina Lacomme, Patricia Marques Sousa, Sophie Leboucher, Torben J Hausrat, Christophe Bosc, Annie Andrieux, Matthias Kneussel, Marc Landry, André Calas, Martin Balastik, Carsten Janke (2018 Nov 12)

Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport.

The EMBO journal. : DOI : e100440
Maria M Magiera, Puja Singh, Carsten Janke (2018 May 31)

SnapShot: Functions of Tubulin Posttranslational Modifications.

Cell : 1552-1552.e1 : DOI : 10.1016/j.cell.2018.05.032
Maria M Magiera, Puja Singh, Sudarshan Gadadhar, Carsten Janke (2018 May 31)

Tubulin Posttranslational Modifications and Emerging Links to Human Disease.

Cell : 1323-1327 : DOI : 10.1016/j.cell.2018.05.018
Renaud Chabrier, Carsten Janke (2018 Mar 1)

The comeback of hand drawing in modern life sciences.

Nature reviews. Molecular cell biology : DOI : 10.1038/nrm.2017.126
Carsten Janke (2018 Feb 19)

A unified reviewing format for grant applications and evaluations.

EMBO reports : 187-188 : DOI : 10.15252/embr.201745611

Year of publication 2017

Carsten Janke, Guillaume Montagnac (2017 Dec 4)

Causes and Consequences of Microtubule Acetylation.

Current biology : CB : R1287-R1292 : DOI : S0960-9822(17)31381-7
Sudarshan Gadadhar, Hala Dadi, Satish Bodakuntla, Anne Schnitzler, Ivan Bièche, Filippo Rusconi, Carsten Janke (2017 Sep 4)

Tubulin glycylation controls primary cilia length.

The Journal of cell biology : 2701-2713 : DOI : 10.1083/jcb.201612050
Kathiresan Natarajan, Sudarshan Gadadhar, Judith Souphron, Maria M Magiera, Carsten Janke (2017 Jun 1)

Molecular interactions between tubulin tails and glutamylases reveal determinants of glutamylation patterns.

EMBO reports : 1013-1026 : DOI : 10.15252/embr.201643751
Montserrat Bosch Grau, Christel Masson, Sudarshan Gadadhar, Cecilia Rocha, Olivia Tort, Patricia Marques Sousa, Sophie Vacher, Ivan Bieche, Carsten Janke (2017 Mar 1)

Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration.

Journal of cell science : DOI : 10.1242/jcs.199091

Year of publication 2015

Carsten Janke, Michel O Steinmetz (2015 Aug 13)

Optochemistry to control the microtubule cytoskeleton.

The EMBO journal : 2114-6 : DOI : 10.15252/embj.201592415

Year of publication 2014

Olivia Tort, Sebastián Tanco, Cecilia Rocha, Ivan Bièche, Cecilia Seixas, Christophe Bosc, Annie Andrieux, Marie-Jo Moutin, Francesc Xavier Avilés, Julia Lorenzo, Carsten Janke (2014 Oct 1)

The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids.

Molecular biology of the cell : 3017-27 : DOI : 10.1091/mbc.E14-06-1072
Cecilia Rocha, Laura Papon, Wulfran Cacheux, Patricia Marques Sousa, Valeria Lascano, Olivia Tort, Tiziana Giordano, Sophie Vacher, Benedicte Lemmers, Pascale Mariani, Didier Meseure, Jan Paul Medema, Ivan Bièche, Michael Hahne, Carsten Janke (2014 Oct 1)

Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon.

The EMBO journal : 2247-60 : DOI : 10.15252/embj.201488466
Carsten Janke (2014 Aug 18)

The tubulin code: molecular components, readout mechanisms, and functions.

The Journal of cell biology : 461-72 : DOI : 10.1083/jcb.201406055
Maria M Magiera, Carsten Janke (2014 May 5)

Post-translational modifications of tubulin.

Current biology : CB : R351-4 : DOI : 10.1016/j.cub.2014.03.032
Annemarie Wehenkel, Carsten Janke (2014 Apr 1)

Towards elucidating the tubulin code.

Nature cell biology : 303-5 : DOI : 10.1038/ncb2938

Year of publication 2013

Carsten Janke (2013 Oct 16)

Mysterious modification of tubulin.

Nature Reviews Molecular Cell BiologyNature Reviews Molecular Cell Biology
Maria M Magiera, Carsten Janke (2013 Aug 27)

Investigating tubulin posttranslational modifications with specific antibodies.

Methods in cell biology : 247-67 : DOI : 10.1016/B978-0-12-407757-7.00016-5
Montserrat Bosch Grau, Gloria Gonzalez Curto, Cecilia Rocha, Maria M Magiera, Patricia Marques Sousa, Tiziana Giordano, Nathalie Spassky, Carsten Janke (2013 Aug 5)

Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia.

The Journal of cell biology : 441-51 : DOI : 10.1083/jcb.201305041