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Unit
Genome Integrity, RNA and Cancer (UMR3348)
The research conducted at the « Genome Integrity, RNA and Cancer » Unit explores multiple aspects of genome dynamics that integrate RNA biology in the context of genome maintenance and expression in normal and pathological situations, including cancer.
Teams
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25
km from Paris
25
nationalities since 2015
25
INTERNATIONAL EVENTS ORGANISED
Key publications
All publications
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The plasticity of mRNA translation during cancer progression and therapy resistanceNature Reviews Cancer
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Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1Nature Communications
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Cytidine Deaminase Deficiency Reveals New Therapeutic Opportunities against CancerClinical Cancer Research
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News
All news
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World Triple Negative Breast Cancer Day: innovation to cure more womenWorld Triple Negative Breast Cancer Day, held on March 3rd, is a reminder that triple-negative breast cancers remain the most difficult to treat, and that only innovation and dynamic research can bring hope of curing more patients.01/03/2024 -
Dr. Albertas Navickas, winner of the prix Ruban Rose Avenir 2023Dr. Albertas Navickas, head of the RNA, Tumor Microenvironment and Metastasis team in the Genome integrity, RNA and Cancer unit (CNRS UMR3348/University Paris-Saclay), was recognized by the Ruban Rose association for his promising project on communication between cancer cells of the breast and the cells of the lungs.24/10/2023 -
New major players in the protection of DNA replication forks are identifiedIn an article published on March 2, 2023, in the journal Molecular Cell, the team led by Sarah Lambert, in collaboration with researchers from the Institute for Integrative Biology of the Cell, revealed a mechanism that ensures the integrity of DNA replication forks. Based on the combination of RNA and the end-joining factor Ku, it represents a potential new therapeutic target to fight cancerous cells.13/03/2023 -
Three research projects at Institut Curie financed by the ERC Synergy GrantThree projects at Institut Curie are laureate of the highly selective and prestigious Synergy Grant 2022 program, awarded by the European Research Council. These three grants, for an amount of 10 million euros each, shine a light on Institut Curie’s excellence and its teams in cellular biology. A breakthrough field to further the fight against cancer.28/10/2022 -
Carsten Janke awarded an ERC Advanced GrantLong-neglected, research on post-translational modifications of microtubules is now a promising field, thanks in particular to Carsten Janke, a world expert in this area. His excellence in this discipline and the hopes placed in his research have been recognized by the European Research Council (ERC).12/08/2022 -
Aglaia Therapeutics devient Ribonexus et signe avec Pierre Fabre un accord de licence exclusif portant sur de petites molécules ciblant la protéine eIF4A, une nouvelle cible en oncologieRibonexus (anciennement Aglaia Therapeutics), une entreprise de biotechnologie développant de nouveaux traitements capables de contrer la résistance aux thérapies ciblées chez les patients atteints de cancer, et le groupe pharmaceutique français Pierre Fabre annoncent aujourd’hui la signature d’un accord de licence exclusif portant sur une série de petites molécules brevetées par Pierre Fabre qui ciblent le facteur d’initiation eukaryotique de la traduction 4A (eIF4A). Fortement exprimée dans plusieurs cancers solides et hématologiques, notamment le mélanome, cette cible est associée à une résistance à de nombreuses thérapies actuelles.18/11/2021
Scientific events
All scientific events
26 Apr
2024
Seminar
11h-12h
On the multiple roads to cell fate decisions: Integrating transcription factors into RNA-regulatory networks
While the current view states that Transcription Factors (TFs) act on DNA regulatory elements to deploy precise gene programs, an emerging concept proposes that TFs also bind RNA and regulate splicing to promote molecular and cellular diversity. Yet, how the RNA regulatory functions of TFs contribute to their key role in cell fates remains puzzling. From in vitro interaction to tissue development,
3 Apr
2024
Seminar
11h-23h
Vimentin intermediate filaments: network architecture and crosstalk with microtubules
The spatial organization and dynamics of the cytoskeleton play crucial roles for various cellular functions. However, despite their essential roles in processes such as cell migration, mechanical stress resilience, and maintaining cellular integrity, the complex nature of vimentin intermediate filament networks continues to elude our understanding. Unlike actin and microtubules, recreating physiol
21 Mar
2024
Institutional seminar "Mayent - Rothschild"
11h-12h
A garden of forking paths: branching, switching and reversal in meiotic recombination
Meiotic recombination involves repair of double strand DNA breaks by homologous recombination to form crossovers and noncrossovers. Current models suggest that different mechanisms form these two products: noncrossovers by synthesis dependent strand annealing; COs by double Holliday junction formation and resolution. In testing these predictions, we found evidence for remarkable dynamism during me
15 Dec
2023
Seminar
11h-12h
The dangerous combination of DNA structures and chromosome gaps: implications for repeat instability and cell survival
The Freudenreich lab uses the yeast Saccharomyces cerevisiae (baker's yeast) as a model organism to study genome instability. In particular, we investigate the molecular basis of two related types of DNA mutations: repeat expansions and chromosome fragility. Expansion of repeat sequences is the cause of more than 20 inherited diseases including Huntington's disease, Fragil
15 Sep
2023
Orsay seminar series
11h-23h
Exploiting self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress
I will present two discoveries from my team dealing with precision medicine approaches and possibilities. The first part deals with widely used genotoxic cancer therapy, such as irradiation. These modalities operate through extensive induction of DNA breaks, yet cancer cells frequently display resistance to such interventions. Intriguingly, studies following the dynamics of radiation-induced DNA l
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