Normal and Pathological Development of Melanocytes

Team Members

Lionel Larue, PhD

Larue

Lionel Larue INSERM Research Director Team Larue Deputy Director Team Leader Tel: Back to the list

Key publications

Year of publication 2018

Pierre Sohier, Léa Legrand, Zackie Aktary, Christine Grill, Véronique Delmas, Florence Bernex, Edouard Reyes-Gomez, Lionel Larue, Béatrice Vergier (2018 May 31)

A histopathological classification system of Tyr::NRAS murine melanocytic lesions: A reproducible simplified classification.

Pigment cell & melanoma research : 423-431 : DOI : 10.1111/pcmr.12677
Pascal Laurent-Gengoux, Valérie Petit, Zackie Aktary, Stuart Gallagher, Luke Tweedy, Laura Machesky, Lionel Larue (2018 May 18)

Simulation of melanoblast displacements reveals new features of developmental migration.

Development (Cambridge, England) : DOI : dev160200
Veronica A Kinsler, Lionel Larue (2018 Jan 31)

The patterns of birthmarks suggest a novel population of melanocyte precursors arising around the time of gastrulation.

Pigment cell & melanoma research : 95-109 : DOI : 10.1111/pcmr.12645
C Grill, L Benzekri, A Rubod, Z Aktary, K Ezzedine, A Taïeb, Y Gauthier, L Larue, V Delmas (2018 Jan 18)

Epidermal melanocytes in segmental vitiligo show altered expression of E-cadherin, but not P-cadherin.

The British journal of dermatology : 1204-1206 : DOI : 10.1111/bjd.16352

Year of publication 2017

Juliette U Bertrand, Valérie Petit, Elke Hacker, Irina Berlin, Nicholas K Hayward, Marie Pouteaux, Evelyne Sage, David C Whiteman, Lionel Larue (2017 Feb 14)

UVB represses melanocyte cell migration and acts through β-catenin.

Experimental dermatology : DOI : 10.1111/exd.13318

Year of publication 2015

F Rambow, A Bechadergue, F Luciani, G Gros, M Domingues, J Bonaventure, G Meurice, J-C Marine, L Larue (2015 Dec 16)

Regulation of melanoma progression through the TCF4/miR-125b/NEDD9 cascade.

The Journal of investigative dermatology : DOI : 10.1016/j.jid.2016.02.803
Florian Rambow, Bastien Job, Valérie Petit, Franck Gesbert, Véronique Delmas, Hannah Seberg, Guillaume Meurice, Eric Van Otterloo, Philippe Dessen, Caroline Robert, Daniel Gautheret, Robert A Cornell, Alain Sarasin, Lionel Larue (2015 Oct 23)

New Functional Signatures for Understanding Melanoma Biology from Tumor Cell Lineage-Specific Analysis.

Cell reports : 840-53 : DOI : 10.1016/j.celrep.2015.09.037
Alejandro Conde-Perez, Gwendoline Gros, Christine Longvert, Malin Pedersen, Valérie Petit, Zackie Aktary, Amaya Viros, Franck Gesbert, Véronique Delmas, Florian Rambow, Boris C Bastian, Andrew D Campbell, Sophie Colombo, Isabel Puig, Alfonso Bellacosa, Owen Sansom, Richard Marais, Leon C L T Van Kempen, Lionel Larue (2015 Aug 27)

A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity.

Nature communications : 6 : 8093 : DOI : 10.1038/ncomms9093

Year of publication 2012

Agathe Valluet, Sabine Druillennec, Céline Barbotin, Coralie Dorard, Anne H Monsoro-Burq, Magalie Larcher, Celio Pouponnot, Manuela Baccarini, Lionel Larue, Alain Eychène (2012 Oct 2)

B-Raf and C-Raf are required for melanocyte stem cell self-maintenance.

Cell reports : 774-80 : DOI : 10.1016/j.celrep.2012.08.020

Year of publication 2011

Salvatore Cortellino, Jinfei Xu, Mara Sannai, Robert Moore, Elena Caretti, Antonio Cigliano, Madeleine Le Coz, Karthik Devarajan, Andy Wessels, Dianne Soprano, Lara K Abramowitz, Marisa S Bartolomei, Florian Rambow, Maria Rosaria Bassi, Tiziana Bruno, Maurizio Fanciulli, Catherine Renner, Andres J Klein-Szanto, Yoshihiro Matsumoto, Dominique Kobi, Irwin Davidson, Christophe Alberti, Lionel Larue, Alfonso Bellacosa (2011 Feb 18)

Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair.

Cell : 67-79 : DOI : 10.1016/j.cell.2011.06.020