New Approaches in Radiotherapy


Yolanda Prezado Team Leader

Radiotherapy (RT) is one of the most frequently used methods for cancer treatment (above 50% of patients will receive RT). Despite remarkable advancements, the dose tolerances of normal tissues continue being the main limitation in RT. Finding novel approaches that allow increasing normal tissue resistance is of utmost importance. This would make it possible to escalate tumour dose, resulting in an improvement in cure rate. Along this line, the team New Approaches in Radiotherapy (NARA) works on the exploration on novel  RT techniques.  NARA is a team pioneering the conception and development of innovative methods based on the use of the spatial fractionation of the dose. This strategy has already shown a remarkable reduction in side effects of the radiation.

Since we do not believe in frontiers, NARA was born with an interdisplinary and international character.  We work at the interphase between medical physics, computing (Monte Carlo simulations), and radiobiology.


image Site YP

Key publications

Year of publication 2020

P Lansonneur, H Mammar, C Nauraye, A Patriarca, E Hierso, R Dendale, Y Prezado, L De Marzi (2020 Apr 29)

First proton minibeam radiation therapy treatment plan evaluation.

Scientific reports : 7025 : DOI : 10.1038/s41598-020-63975-9

Year of publication 2019

Yolanda Prezado, Gregory Jouvion, Consuelo Guardiola, Wilfredo Gonzalez, Marjorie Juchaux, Judith Bergs, Catherine Nauraye, Dalila Labiod, Ludovic De Marzi, Frederic Pouzoulet, Annalisa Patriarca, Remi Dendale (2019 Feb 1)

Tumor Control in RG2 Glioma-Bearing Rats: A Comparison Between Proton Minibeam Therapy and Standard Proton Therapy.

International journal of radiation oncology, biology, physics : 266-271 : DOI : S0360-3016(19)30171-3

Year of publication 2018

Yolanda Prezado, Gregory Jouvion, Annalisa Patriarca, Catherine Nauraye, Consuelo Guardiola, Marjorie Juchaux, Charlotte Lamirault, Dalila Labiod, Laurene Jourdain, Catherine Sebrie, Remi Dendale, Wilfredo Gonzalez, Frederic Pouzoulet (2018 Nov 9)

Proton minibeam radiation therapy widens the therapeutic index for high-grade gliomas.

Scientific reports : 16479 : DOI : 10.1038/s41598-018-34796-8
Ludovic De Marzi, Annalisa Patriarca, Catherine Nauraye, Eric Hierso, Rémi Dendale, Consuelo Guardiola, Yolanda Prezado (2018 Oct 13)

Implementation of planar proton minibeam radiation therapy using a pencil beam scanning system: A proof of concept study.

Medical physics : 5305-5316 : DOI : 10.1002/mp.13209

Year of publication 2017

Y Prezado, M Dos Santos, W Gonzalez, G Jouvion, C Guardiola, S Heinrich, D Labiod, M Juchaux, L Jourdain, C Sebrie, F Pouzoulet (2017 Dec 13)

Transfer of Minibeam Radiation Therapy into a cost-effective equipment for radiobiological studies: a proof of concept.

Scientific reports : 17295 : DOI : 10.1038/s41598-017-17543-3
Yolanda Prezado, Gregory Jouvion, David Hardy, Annalisa Patriarca, Catherine Nauraye, Judith Bergs, Wilfredo González, Consuelo Guardiola, Marjorie Juchaux, Dalila Labiod, Remi Dendale, Laurène Jourdain, Catherine Sebrie, Frederic Pouzoulet (2017 Nov 2)

Proton minibeam radiation therapy spares normal rat brain: Long-Term Clinical, Radiological and Histopathological Analysis.

Scientific reports : 14403 : DOI : 10.1038/s41598-017-14786-y
All publications