UMR 3347/U1021 – Signaling, Radiobiology and Cancer

Melanoma is a very aggressive tumor originating from neural-crest derived melanocytes. The transformation of normal melanocytes into melanoma cells is a multistep process. It is crucial to elucidate the molecular and cellular mechanisms of melanocyte development (specially the molecular network that controls the induction of neural crest) and transformation, to improve the prevention, early diagnosis, prognosis and therapy.

Our research combines molecular approaches based on an understanding of the signaling associated with extracellular factors, a cellular approach based on an understanding of the establishment/maintenance and alteration of the melanocyte lineage and an approach based on animal models that will be used to test specific innovative treatments. In fine, we expect that we can ultimately propose new prognostic markers for melanoma and improved therapeutic treatments.

Key publications

Year of publication 2021

Alexandre Leduc, Samia Chaouni, Frédéric Pouzoulet, Ludovic De Marzi, Frédérique Megnin-Chanet, Erwan Corre, Dinu Stefan, Jean-Louis Habrand, François Sichel, Carine Laurent (2021 Mar 13)

Differential normal skin transcriptomic response in total body irradiated mice exposed to scattered versus scanned proton beams.

Scientific reports : 11 : 5876 : DOI : 10.1038/s41598-021-85394-0
Marios Sotiropoulos, Elise Brisebard, Marine Le Dudal, Gregory Jouvion, Marjorie Juchaux, Delphine Crépin, Catherine Sebrie, Laurene Jourdain, Dalila Labiod, Charlotte Lamirault, Frederic Pouzoulet, Yolanda Prezado (2021 Jan 29)

X-rays minibeam radiation therapy at a conventional irradiator: Pilot evaluation in F98-glioma bearing rats and dose calculations in a human phantom.

Clinical and translational radiation oncology : 44-49 : DOI : 10.1016/j.ctro.2021.01.001

Year of publication 2020

Charlotte Lamirault, Elise Brisebard, Annalisa Patriarca, Marjorie Juchaux, Delphine Crepin, Dalila Labiod, Frederic Pouzoulet, Catherine Sebrie, Laurene Jourdain, Marine Le Dudal, David Hardy, Ludovic de Marzi, Remi Dendale, Gregory Jouvion, Yolanda Prezado (2020 Sep 29)

Spatially Modulated Proton Minibeams Results in the Same Increase of Lifespan as a Uniform Target Dose Coverage in F98-Glioma-Bearing Rats.

Radiation research : DOI : 10.1667/RADE-19-00013.1
Sofia Ferreira, Chloe Foray, Alberto Gatto, Magalie Larcher, Sophie Heinrich, Mihaela Lupu, Joel Mispelter, François D Boussin, Célio Pouponnot, Marie Dutreix (2020 Sep 9)

AsiDNA Is a Radiosensitizer with no Added Toxicity in Medulloblastoma Pediatric Models.

Clinical cancer research : an official journal of the American Association for Cancer Research : 5735-5746 : DOI : 10.1158/1078-0432.CCR-20-1729
Charlotte Lamirault, Valérie Doyère, Marjorie Juchaux, Frederic Pouzoulet, Dalila Labiod, Remi Dendale, Annalisa Patriarca, Catherine Nauraye, Marine Le Dudal, Grégory Jouvion, David Hardy, Nicole El Massioui, Yolanda Prezado (2020 Aug 13)

Short and long-term evaluation of the impact of proton minibeam radiation therapy on motor, emotional and cognitive functions.

Scientific reports : 13511 : DOI : 10.1038/s41598-020-70371-w
Hadi T Nia, Meenal Datta, Giorgio Seano, Sue Zhang, William W Ho, Sylvie Roberge, Peigen Huang, Lance L Munn, Rakesh K Jain (2020 Jul 19)

In vivo compression and imaging in mouse brain to measure the effects of solid stress.

Nature protocols : DOI : 10.1038/s41596-020-0328-2