UMR 3347/U1021 – Normal & Pathological Signaling: from the embryo to the innovative therapy of cancers

Melanoma is a very aggressive tumor originating from neural-crest derived melanocytes. The transformation of normal melanocytes into melanoma cells is a multistep process. It is crucial to elucidate the molecular and cellular mechanisms of melanocyte development (specially the molecular network that controls the induction of neural crest) and transformation, to improve the prevention, early diagnosis, prognosis and therapy.

Our research combines molecular approaches based on an understanding of the signaling associated with extracellular factors, a cellular approach based on an understanding of the establishment/maintenance and alteration of the melanocyte lineage and an approach based on animal models that will be used to test specific innovative treatments. In fine, we expect that we can ultimately propose new prognostic markers for melanoma and improved therapeutic treatments.

Key publications

Year of publication 2018

Alexandra Garancher, Charles Y Lin, Morgane Morabito, Wilfrid Richer, Nathalie Rocques, Magalie Larcher, Laure Bihannic, Kyle Smith, Catherine Miquel, Sophie Leboucher, Nirmitha I Herath, Fanny Dupuy, Pascale Varlet, Christine Haberler, Christine Walczak, Nadine El Tayara, Andreas Volk, Stéphanie Puget, François Doz, Olivier Delattre, Sabine Druillennec, Olivier Ayrault, Robert J Wechsler-Reya, Alain Eychène, Franck Bourdeaut, Paul A Northcott, Celio Pouponnot (2018 Mar 14)

NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma.

Cancer cell : 435-449.e6 : DOI : S1535-6108(18)30059-X

Year of publication 2017

Giorgio Seano (2017 Nov 15)

Targeting the perivascular niche in brain tumors.

Current opinion in oncology : 54-60 : DOI : 10.1097/CCO.0000000000000417
Jean-Louis Plouhinec, Sofía Medina-Ruiz, Caroline Borday, Elsa Bernard, Jean-Philippe Vert, Michael B Eisen, Richard M Harland, Anne H Monsoro-Burq (2017 Oct 20)

A molecular atlas of the developing ectoderm defines neural, neural crest, placode, and nonneural progenitor identity in vertebrates.

PLoS biology : e2004045 : DOI : 10.1371/journal.pbio.2004045
Ana Leonor Figueiredo, Frédérique Maczkowiak, Caroline Borday, Patrick Pla, Meghane Sittewelle, Caterina Pegoraro, Anne H Monsoro-Burq (2017 Oct 18)

PFKFB4 control of AKT signaling is essential for premigratory and migratory neural crest formation.

Development (Cambridge, England) : 4183-4194 : DOI : 10.1242/dev.157644
Sylvain Thierry, Wael Jdey, Solana Alculumbre, Vassili Soumelis, Patricia Noguiez-Hellin, Marie Dutreix (2017 Sep 27)

The DNA repair inhibitor Dbait is specific for malignant hematologic cells in blood.

Molecular cancer therapeutics : DOI : molcanther.0405.2017
Biau J., Chautard E., De Koning L., Court F., Pereira B., Verrelle P., Dutreix M. (2017 Jul 1)

Predictive biomarkers of resistance to hypofractionated radiotherapy in high grade glioma

RADIATION ONCOLOGY : 12 : 123 : DOI : 10.1186/s13014-017-0858-0