UMR 3347/U1021 – Signaling, Radiobiology and Cancer

Melanoma is a very aggressive tumor originating from neural-crest derived melanocytes. The transformation of normal melanocytes into melanoma cells is a multistep process. It is crucial to elucidate the molecular and cellular mechanisms of melanocyte development (specially the molecular network that controls the induction of neural crest) and transformation, to improve the prevention, early diagnosis, prognosis and therapy.

Our research combines molecular approaches based on an understanding of the signaling associated with extracellular factors, a cellular approach based on an understanding of the establishment/maintenance and alteration of the melanocyte lineage and an approach based on animal models that will be used to test specific innovative treatments. In fine, we expect that we can ultimately propose new prognostic markers for melanoma and improved therapeutic treatments.

Key publications

Year of publication 2020

P Lansonneur, H Mammar, C Nauraye, A Patriarca, E Hierso, R Dendale, Y Prezado, L De Marzi (2020 Apr 29)

First proton minibeam radiation therapy treatment plan evaluation.

Scientific reports : 7025 : DOI : 10.1038/s41598-020-63975-9

Year of publication 2019

Leruste A, Tosello J, Ramos RN, Tauziède-Espariat A, Brohard S, Han ZY, Beccaria K, Andrianteranagna M, Caudana P, Nikolic J, Chauvin C, Niborski LL, Manriquez V, Richer W, Masliah-Planchon J, Grossetête-Lalami S, Bohec M, Lameiras S, Baulande S, Pouponnot C, Coulomb A, Galmiche L, Surdez D, Servant N, Helft J, Sedlik C, Puget S, Benaroch P, Delattre O, Waterfall JJ, Piaggio E, Bourdeaut F. (2019 Dec 9)

Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors.

Cancer Cell : 36(6) : 597-612 : DOI : 10.1016/j.ccell.2019.10.008
Charles Fouillade, Sandra Curras-Alonso, Lorena Giuranno, Eddy Quelennec, Sophie Heinrich, Sarah Bonnet-Boissinot, Arnaud Beddok, Sophie Leboucher, Hamza Umut Karakurt, Mylène Bohec, Sylvain Baulande, Marc Vooijs, Pierre Verrelle, Marie Dutreix, Arturo Londoño-Vallejo, Vincent Favaudon (2019 Dec 5)

FLASH Irradiation Spares Lung Progenitor Cells and Limits the Incidence of Radio-induced Senescence.

Clinical cancer research : an official journal of the American Association for Cancer Research : DOI : 10.1158/1078-0432.CCR-19-1440
Giorgio Seano, Rakesh K Jain (2019 Nov 4)

Vessel co-option in glioblastoma: emerging insights and opportunities.

Angiogenesis : DOI : 10.1007/s10456-019-09691-z
Wael Jdey, Maria Kozlak, Sergey Alekseev, Sylvain Thierry, Pauline Lascaux, Pierre-Marie Girard, Françoise Bono, Marie Dutreix (2019 Jul 31)

AsiDNA Treatment Induces Cumulative Antitumor Efficacy with a Low Probability of Acquired Resistance.

Neoplasia (New York, N.Y.) : 863-871 : DOI : S1476-5586(19)30213-1
Francesca Bufalieri, Paola Infante, Flavia Bernardi, Miriam Caimano, Paolo Romania, Marta Moretti, Ludovica Lospinoso Severini, Julie Talbot, Ombretta Melaiu, Mirella Tanori, Laura Di Magno, Diana Bellavia, Carlo Capalbo, Stéphanie Puget, Enrico De Smaele, Gianluca Canettieri, Daniele Guardavaccaro, Luca Busino, Angelo Peschiaroli, Simonetta Pazzaglia, Giuseppe Giannini, Gerry Melino, Franco Locatelli, Alberto Gulino, Olivier Ayrault, Doriana Fruci, Lucia Di Marcotullio (2019 Jul 26)

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP.

Nature communications : 3304 : DOI : 10.1038/s41467-019-11093-0