UMR 3347/U1021 – Signaling, Radiobiology and Cancer

Melanoma is a very aggressive tumor originating from neural-crest derived melanocytes. The transformation of normal melanocytes into melanoma cells is a multistep process. It is crucial to elucidate the molecular and cellular mechanisms of melanocyte development (specially the molecular network that controls the induction of neural crest) and transformation, to improve the prevention, early diagnosis, prognosis and therapy.

Our research combines molecular approaches based on an understanding of the signaling associated with extracellular factors, a cellular approach based on an understanding of the establishment/maintenance and alteration of the melanocyte lineage and an approach based on animal models that will be used to test specific innovative treatments. In fine, we expect that we can ultimately propose new prognostic markers for melanoma and improved therapeutic treatments.

Key publications

Year of publication 2020

Hadi T Nia, Meenal Datta, Giorgio Seano, Sue Zhang, William W Ho, Sylvie Roberge, Peigen Huang, Lance L Munn, Rakesh K Jain (2020 Jul 19)

In vivo compression and imaging in mouse brain to measure the effects of solid stress.

Nature protocols : DOI : 10.1038/s41596-020-0328-2
Pierluigi Scerbo, Anne H Monsoro-Burq (2020 Jun 5)

The vertebrate-specific VENTX/NANOG gene empowers neural crest with ectomesenchyme potential.

Science advances : eaaz1469 : DOI : 10.1126/sciadv.aaz1469
Julie U Bertrand, Eirikur Steingrimsson, Fanélie Jouenne, Brigitte Bressac-de Paillerets, Lionel Larue (2020 Apr 30)

Melanoma Risk and Melanocyte Biology.

Acta dermato-venereologica : adv00139 : DOI : 10.2340/00015555-3494
P Lansonneur, H Mammar, C Nauraye, A Patriarca, E Hierso, R Dendale, Y Prezado, L De Marzi (2020 Apr 29)

First proton minibeam radiation therapy treatment plan evaluation.

Scientific reports : 7025 : DOI : 10.1038/s41598-020-63975-9

Year of publication 2019

Charles Fouillade, Sandra Curras-Alonso, Lorena Giuranno, Eddy Quelennec, Sophie Heinrich, Sarah Bonnet-Boissinot, Arnaud Beddok, Sophie Leboucher, Hamza Umut Karakurt, Mylène Bohec, Sylvain Baulande, Marc Vooijs, Pierre Verrelle, Marie Dutreix, Arturo Londoño-Vallejo, Vincent Favaudon (2019 Dec 5)

FLASH Irradiation Spares Lung Progenitor Cells and Limits the Incidence of Radio-induced Senescence.

Clinical cancer research : an official journal of the American Association for Cancer Research : DOI : 10.1158/1078-0432.CCR-19-1440
Giorgio Seano, Rakesh K Jain (2019 Nov 4)

Vessel co-option in glioblastoma: emerging insights and opportunities.

Angiogenesis : DOI : 10.1007/s10456-019-09691-z