Chemistry and Modelling for Protein Recognition

Team Members

Sandrine Piguel

S. PIGUEL

Sandrine Piguel Team Mahuteau-Betzer Associate Professor - Univiversité Paris-Saclay Tel: Back to the list

Key publications

Year of publication 2020

Breton-Patient C., Naud-Martin D., Mahuteau-Betzer F., Piguel S. (2020 Oct 14)

Three-component C-H bond sulfonylation of imidazoheterocycles via visible-light organophotoredox catalysis.

European Journal of Organic Chemistry : Accepted Article : DOI : 10.1002/ejoc.202001219
Leandro H. Zucolotto Cocca, Luis M. G. Abegão, Lucas F. Sciuti, Roxane Vabre, Jonathas de Paula Siqueira, Kenji Kamada, Cleber R. Mendonca, Sandrine Piguel, and Leonardo De Boni (2020 Jun 11)

Two-Photon Emissive Dyes Based on Push–Pull Purines Derivatives: Toward the Development of New Photoluminescence Bioprobes

The Journal of Physical Chemistry C : 124 : 12185-12864 : DOI : 10.1021/acs.jpcc.0c01859
Julie Le Bescont, Chloé Breton‐Patient et Sandrine Piguel (2020 Apr 16)

Unconventional Reactivity with DABCO-Bis(sulfur dioxide): C–H Bond Sulfenylation of Imidazopyridines

European Journal of Organic Chemistry : 2020 : 2101-2109 : DOI : 10.1002/ejoc.202000112

Year of publication 2019

Abegão L.M.G., Fonseca R.D., Santos F.A., Rodrigues J.J., Kamada K., Mendonça C.R., Piguel S., De Boni L. (2019 Aug 23)

First molecular electronic hyperpolarizability of series of π-conjugated oxazole dyes in solution: an experimental and theoretical study

RSC Adv. : 9 : 26476-26482 : DOI : 10.1039/C9RA05246A

Year of publication 2018

Tom Baladi, Jessy Aziz, Florent Dufour, Valentina Abet, Véronique Stoven, François Radvanyi, Florent Poyer, Ting-Di Wu, Jean-Luc Guerquin-Kern, Isabelle Bernard-Pierrot, Sergio Marco Garrido, Sandrine Piguel (2018 Nov 1)

Design, synthesis, biological evaluation and cellular imaging of imidazo[4,5-b]pyridine derivatives as potent and selective TAM inhibitors.

Bioorganic & medicinal chemistry : 26 : 5510-5530 : DOI : 10.1016/j.bmc.2018.09.031
Luis M.G. Abegão, Ruben D Fonseca, Tárcius N Ramos, Florence Mahuteau-Betzer, Sandrine PIGUEL, José J. Rodrigues Jr, Cleber R. Mendonca, Sylvio Canuto, Daniel Luis Silva, and Leonardo De Boni (2018 Apr 12)

Oxazole dyes with potential for photoluminescence bioprobes: A two-Photon absorption study

The Journal of Physical Chemistry C : 122 : 10526-10534 : DOI : 10.1021/acs.jpcc.8b01904
Marius Mamone, Jessy Aziz, Julie Le Bescont, Sandrine Piguel (2018 Jan 18)

Aminocarbonylation of N-Containing Heterocycles with Aromatic Amines Using Mo(CO)6

Synthesis : 50 : 1521-1526 : DOI : 10.1055/s-0037-1609152

Year of publication 2017

Aziz Jessy, Piguel Sandrine (2017 Aug 25)

An update on direct C–H bond functionalization of nitrogen-containing fused heterocycles

Synthesis : 49 : 4562-4585 : DOI : 10.1055/s-0036-1590859

Year of publication 2016

Baladi T., Granzhan A., Piguel S. (2016 May 1)

Microwave-Assisted C-2 Direct Alkenylation of Imidazo[4,5-b]pyridines: Access to Fluorescent Purine Isosteres with Remarkably Large Stokes Shifts

European Journal of Organic Chemistry : 2016 : 2421-2434 : DOI : 10.1002/ejoc.201600166
Jessy Aziz, Tom Baladi, Sandrine Piguel (2016 Apr 26)

Direct Alkynylation of 3H-Imidazo[4,5-b]pyridines Using gem-Dibromoalkenes as Alkynes Source.

The Journal of organic chemistry : 81 : 4122-4133 : DOI : 10.1021/acs.joc.6b00406

Year of publication 2015

Tom Baladi, Valentina Abet, Sandrine Piguel (2015 Nov 13)

State-of-the-art of small molecule inhibitors of the TAM family: the point of view of the chemist.

European journal of medicinal chemistry : 105 : 220-37 : DOI : 10.1016/j.ejmech.2015.10.003

Year of publication 2014

Vabre R., Legraverend M., Piguel S. (2014 Jun 1)

Synthesis and evaluation of spectroscopic properties of newly synthesized push–pull 6-amino-8-styryl purines

Dyes and Pigments : 105 : 145-151 : DOI : 10.1016/j.dyepig.2014.01.025
Vabre R., Couradin J., Naud-Martin D., Legraverend M., Piguel S. (2014 Jan 1)

Palladium-Catalyzed Cross-Coupling between 8-Substituted 6-Thiophenyl­purines and Boronic Acids

Synthesis : 46 : 933-942 : DOI : 10.1055/s-0033-1340734

Year of publication 2013

Ténin Traoré, Andrea Cavagnino, Nicolas Saettel, François Radvanyi, Sandrine Piguel, Isabelle Bernard-Pierrot, Véronique Stoven, Michel Legraverend (2013 Nov 19)

New aminopyrimidine derivatives as inhibitors of the TAM family.

European journal of medicinal chemistry : 70 : 789-801 : DOI : 10.1016/j.ejmech.2013.10.037
Mahuteau-Betzer F., Piguel S. (2013 Jun 12)

Synthesis and evaluation of photophysical properties of Series of π-conjugated oxazole dyes

Tetrahedron Letters : 54 : 3188-3193 : DOI : https://doi.org/10.1016/j.tetlet.2013.04.037
Rosa M Suárez, Franciane Chevot, Andrea Cavagnino, Nicolas Saettel, François Radvanyi, Sandrine Piguel, Isabelle Bernard-Pierrot, Véronique Stoven, Michel Legraverend (2013 Mar 1)

Inhibitors of the TAM subfamily of tyrosine kinases: synthesis and biological evaluation.

European journal of medicinal chemistry : 2-25 : DOI : 10.1016/j.ejmech.2012.06.005

Year of publication 2012

Chevot F., Vabre R., Piguel S., Legraverend M. (2012 Apr 11)

Palladium-Catalyzed Amidation and Amination of 8-Iodopurine

European Journal of Organic Chemistry : 2012 : 2889-2893 : DOI : 10.1002/ejoc.201200168

Year of publication 2011

Vabre R., Chevot F., Legraverend M., Piguel S. (2011 Jan 1)

Microwave-Assisted Pd/Cu-Catalyzed C-8 Direct Alkenylation of Purines and Related Azoles: An Alternative Access to 6,8,9-Trisubstituted Purines

The Journal of Organic Chemistry : 76 : 9542-9547 : DOI : 10.1021/jo201893h

Year of publication 2010

Pacheco Berciano B., Lebrequier S., Besselièvre F., Piguel S. (2010 Sep 1)

1,1-Dibromo-1-alkenes as Valuable Partners in the Copper-Catalyzed Direct Alkynylation of Azoles

Organic Letters : 12 : 4038-4041 : DOI : 10.1021/ol1016433

Year of publication 2009

François Besselièvre, Sandrine Piguel (2009 Dec 7)

Copper as a powerful catalyst in the direct alkynylation of azoles.

Angewandte Chemie (International ed. in English) : 48 : 9553-9556 : DOI : 10.1002/anie.200904776
François Besselièvre, Sabrina Lebrequier, Florence Mahuteau-Betzer, Sandrine Piguel (2009 Sep 3)

C-H Bond Activation: A Versatile Protocol for the Direct Arylation and Alkenylation of Oxazoles

Synthesis : 2009 : 3511-3518 : DOI : 10.1055/s-0029-1216987

Year of publication 2008

Besselièvre F., Piguel S., Mahuteau-Betzer F., Grierson D.S. (2008 Aug 23)

Stereoselective Direct Copper-Catalyzed Alkenylation of Oxazoles with Bromoalkenes

Organic Letters : 10 : 4029-4032 : DOI : 10.1021/ol801512q
François Besselièvre, Florence Mahuteau-Betzer, David S Grierson, Sandrine Piguel (2008 Mar 20)

Ligandless microwave-assisted Pd/Cu-catalyzed direct arylation of oxazoles

The Journal of organic chemistry : 3278-3280 : DOI : 10.1021/jo7027135