Modeling and Multimodal and Multiparametric Imaging

Our goal is to contribute, via integrated-imaging approaches and molecular modelling, to drug design and to the understanding of the effects and action mechanisms of diagnostic, therapeutic, and theranostic agents on cells, tissues and organisms.

 

Example of image processing and software development for chemical mapping: EFTEM-TomoJ user interface (left) and workflow including multivariate statistical analysis for signal-to-noise ratio improvement (right). From Messaoudi et al. 2013. Microsc. Microanal. 28:1-9).
Example of image processing and software development for chemical mapping: EFTEM-TomoJ user interface (left) and workflow including multivariate statistical analysis for signal-to-noise ratio improvement (right). From Messaoudi et al. 2013. Microsc. Microanal. 28:1-9).

For this purpose, we develop and optimize methods and tools (software, image acquisition procedures, preparation techniques and methods to improve sensitivity and resolution of imaging equipment) in the context of multimodal and/or multiscale imaging (including nano-SIMS, TEM-STEM-EFTEM, MRI) and molecular modelling (docking and dynamics). We mainly apply these developments to oncology and radio-biology thru close collaborations with several biology groups. We focus our activities on:

  1. the multiparametric/multiscale imaging developments to assess heterogeneity of healthy and cancer tissues characteristics
  2. the understanding of the effects of photon irradiation of photosensitizing molecules
  3. the characterization and tracking of radiosensitizing nanoparticles and drugs within cells
  4. the study of the bio-distribution and pharmacokinetic of drugs and chemical elements (I, P, Ca, Fe,….) in normal or pathogenic tissues and cells
  5. the search of small molecules with medicinal interest by computer-aided drug design
  6. the understanding at the atomic level of the mechanism of action of some proteins of biological interest by the use of normal mode analysis (NMA) and molecular dynamics (MD).

The developments and tools we design becomes accessible to academic users and corporations through the facilities depending on us (MRI, chemical mapping and tomography as part of the Cellular and Imaging facility of the Institut Curie) and through the Institut Carnot-Global Care.

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Key publications

Year of publication 2019

Yangwei Deng, Hui Chen, Xinfeng Tao, Fangyi Cao, Sylvain Trépout, Jun Ling, Min-Hui Li (2019 Jul 31)

Oxidation-Sensitive Polymersomes Based on Amphiphilic Diblock Copolypeptoids.

Biomacromolecules : XXXX : XXXX-XXXX : DOI : 10.1021/acs.biomac.9b00713
S Houari, E Picard, T Wurtz, E Vennat, N Roubier, T D Wu, J L Guerquin-Kern, M Duttine, T T Thuy, A Berdal, S Babajko (2019 Jul 23)

Disrupted Iron Storage in Dental Fluorosis.

Journal of dental research : 98 : 994-1001 : DOI : 10.1177/0022034519855650
Dapeng Zhang, Yujiao Fan, Hui Chen, Sylvain Trépout, Min-Hui Li (2019 Jul 22)

CO2-activated reversible transition between polymersomes and micelles with AIE fluorescence.

Angewandte Chemie (International ed. in English) : 58 : 10260-10265 : DOI : 10.1002/anie.201905089
Trépout S. (2019 Jul 16)

Tomographic Collection of Block-Based Sparse STEM Images: Practical Implementation and Impact on the Quality of the 3D Reconstructed Volume

Materials : 12 : 2281 : DOI : 10.3390/ma12142281
B. Augé, E. Dartois, J. Duprat, C. Engrand, G. Slodzian, T.D. Wu, J.L. Guerquin-Kern, H. Vermesse, A. N. Agnihotri, P. Boduch, H. Rothard (2019 Jun 21)

Hydrogen isotopic anomalies in extraterrestrial organic matter: Role of cosmic ray irradiation and implications for UCAMMs

Astronomy & Astrophysics : 627 : A122 : DOI : 10.1051/0004-6361/201935143
Ouahiba Sihali-Beloui, Djamila Aroune, Fella Benazouz, Adile Hadji, Salima El-Aoufi, Sergio Marco (2019 Jun 2)

A hypercaloric diet induces hepatic oxidative stress, infiltration of lymphocytes, and mitochondrial reshuffle in Psammomys obesus, a murine model of insulin resistance.

Comptes rendus biologies : DOI : 10.1016/j.crvi.2019.04.003
All publications