Our goal is to contribute, via integrated-imaging approaches and molecular modelling, to drug design and to the understanding of the effects and action mechanisms of diagnostic, therapeutic, and theranostic agents on cells, tissues and organisms.
For this purpose, we develop and optimize methods and tools (software, image acquisition procedures, preparation techniques and methods to improve sensitivity and resolution of imaging equipment) in the context of multimodal and/or multiscale imaging (including nano-SIMS, TEM-STEM-EFTEM, MRI) and molecular modelling (docking and dynamics). We mainly apply these developments to oncology and radio-biology thru close collaborations with several biology groups. We focus our activities on:
- the multiparametric/multiscale imaging developments to assess heterogeneity of healthy and cancer tissues characteristics
- the understanding of the effects of photon irradiation of photosensitizing molecules
- the characterization and tracking of radiosensitizing nanoparticles and drugs within cells
- the study of the bio-distribution and pharmacokinetic of drugs and chemical elements (I, P, Ca, Fe,….) in normal or pathogenic tissues and cells
- the search of small molecules with medicinal interest by computer-aided drug design
- the understanding at the atomic level of the mechanism of action of some proteins of biological interest by the use of normal mode analysis (NMA) and molecular dynamics (MD).
The developments and tools we design becomes accessible to academic users and corporations through the facilities depending on us (MRI, chemical mapping and tomography as part of the Cellular and Imaging facility of the Institut Curie) and through the Institut Carnot-Global Care.