UMR9187 / U1196 – Chemistry, Modelling and Imaging for Biology (CMIB)

The central activity of the CMIB unit is to develop small molecules to probe and control the biological activities of key targets involved in cancer.

These are mainly non-B nucleic acid structures (Quadruplexes) and Kinases. IR-photoexcitable probes designed both for subcellular tracking and targeted photodamage represents also an important research axis. The drug and probe discovery activity is sustained by Molecular Modelling approaches and Multimodal Imaging (TEM, NanoSIMS, IRM). The CMIB unit is hosting the Institut Curie–CNRS proprietary library comprised of over 9000 chemical compounds and the preclinical IRM imaging and chemical imaging facilities

The main research themes of the unit include:

  • G-quadruplex targeting agents
  • DNA targeted fluorescent dyes
  • Kinase inhibitors
  • Photo and radiosensitizers for Retinoblastoma and Glioblastoma therapy.
  • Medicinal chemistry (Hit to lead optimization, building of focused libraries)
  • Molecular dynamics and virtual screening
  • Multimodal imaging for 2D and 3D chemical mapping
  • Development of software and Image acquisition, processing and analysis

Key publications

Year of publication 2017

Morgan Pellerano, Sergey Tcherniuk, Corine Perals, Thi Nhu Ngoc Van, Elsa Garcin, Florence Mahuteau-Betzer, Marie-Paule Teulade-Fichou, May C Morris (2017 Apr 22)

Targeting Conformational Activation of CDK2 Kinase.

Biotechnology journal : DOI : 10.1002/biot.201600531
Guillaume Kellermann, Florent Dingli, Vanessa Masson, Daniel Dauzonne, Evelyne Ségal-Bendirdjian, Marie-Paule Teulade-Fichou, Damarys Loew, Sophie Bombard (2017 Feb 11)

Exploring the mechanism of inhibition of human telomerase by cysteine-reactive compounds.

FEBS letters : DOI : 10.1002/1873-3468.12589
Gilles Galvani, K Harsha Vardhan Reddy, Claire Beauvineau, NourEddine Ghermani, Florence Mahuteau-Betzer, Mouad Alami, Samir Messaoudi (2017 Feb 9)

Conversion of 3-Bromo-2H-coumarins to 3-(Benzofuran-2-yl)-2H-coumarins under Palladium Catalysis: Synthesis and Photophysical Properties Study.

Organic letters : DOI : 10.1021/acs.orglett.7b00069
Sofia Rivera, Céline Leteur, Frédérique Mégnin, Frédéric Law, Isabelle Martins, Ioana Kloos, Stéphane Depil, Nazanine Modjtahedi, Jean Luc Perfettini, Christophe Hennequin, Eric Deutsch (2017 Jan 28)

Time dependent modulation of tumor radiosensitivity by a pan HDAC inhibitor: abexinostat.

Oncotarget : DOI : 10.18632/oncotarget.14813
Naoko Kotera, Régis Guillot, Marie-Paule Teulade-Fichou, Anton Granzhan (2017 Jan 21)

Copper(II)-Controlled Molecular Glue for Mismatched DNA.

Chembiochem : a European journal of chemical biology : DOI : 10.1002/cbic.201600675
Michael J Lecours, Adrien Marchand, Ahdia Anwar, Corinne Guetta, W Scott Hopkins, Valérie Gabelica (2017 Jan 15)

What stoichiometries determined by mass spectrometry reveal about the ligand binding mode to G-quadruplex nucleic acids.

Biochimica et biophysica acta : DOI : 10.1016/j.bbagen.2017.01.010