The central activity of the CMIB unit is to develop small molecules to probe and control the biological activities of key targets involved in cancer (These are mainly non-B nucleic acid structures (Quadruplexes) and Kinases).
IR-photoexcitable probes designed both for subcellular tracking and targeted photodamage represents also an important research axis. The drug and probe discovery activity is sustained by Molecular Modelling approaches and Multimodal Imaging (TEM, NanoSIMS, IRM). The CMIB unit is hosting the Institut Curie–CNRS proprietary library comprised of over 9000 chemical compounds and the preclinical IRM imaging and chemical imaging facilities
The main research themes of the unit include:
- G-quadruplex targeting agents
- DNA targeted fluorescent dyes
- Kinase inhibitors
- Photo and radiosensitizers for Retinoblastoma and Glioblastoma therapy.
The main methodological approaches are :
- Chemical biology and medicinal chemistry (Hit to lead optimization)
- Molecular dynamics and virtual screening
- Multimodal imaging for 2D and 3D chemical mapping
- Development of software and Image acquisition, processing and analysis