UMR9187 / U1196 – Chemistry, Modelling and Imaging for Biology (CMIB)

The central activity of the CMIB unit is to develop small molecules to probe and control the biological activities of key targets involved in cancer.

These are mainly non-B nucleic acid structures (Quadruplexes) and Kinases. IR-photoexcitable probes designed both for subcellular tracking and targeted photodamage represents also an important research axis. The drug and probe discovery activity is sustained by Molecular Modelling approaches and Multimodal Imaging (TEM, NanoSIMS, IRM). The CMIB unit is hosting the Institut Curie–CNRS proprietary library comprised of over 9000 chemical compounds and the preclinical IRM imaging and chemical imaging facilities

The main research themes of the unit include:

  • G-quadruplex targeting agents
  • DNA targeted fluorescent dyes
  • Kinase inhibitors
  • Photo and radiosensitizers for Retinoblastoma and Glioblastoma therapy.
  • Medicinal chemistry (Hit to lead optimization, building of focused libraries)
  • Molecular dynamics and virtual screening
  • Multimodal imaging for 2D and 3D chemical mapping
  • Development of software and Image acquisition, processing and analysis

Key publications

Year of publication 2018

David Partouche, Antoine Malabirade, Thomas Bizien, Marisela Velez, Sylvain Trépout, Sergio Marco, Valeria Militello, Christophe Sandt, Frank Wien & Véronique Arluison (2018 Feb 27)

Techniques to Analyze sRNA Protein Cofactor Self-Assembly In Vitro

Bacterial Regulatory RNA. Methods in Molecular Biology : 1737 : 321-340 : DOI : 10.1007/978-1-4939-7634-8_18
Ludivine Guyon, Marc Pirrotta, Katerina Duskova, Anton Granzhan, Marie-Paule Teulade-Fichou, David Monchaud (2018 Feb 16)

TWJ-Screen: an isothermal screening assay to assess ligand/DNA junction interactions in vitro

Nucleic Acids Research : 46 : e16 : DOI : 10.1093/nar/gkx1118
Chen, Su; Poyer, Florent; Garcia, Guillaume; Fiorini-Debuisschert, Céline; Rosilio, Véronique and Maillard, Philippe (2018 Feb 14)

Amphiphilic Glycoconjugated Porphyrin Heterodimers as Two-Photon Excitable Photosensitizers: Design, Synthesis, Photophysical and Photobiological Studies

ChemistrySelect : 3 : 1887-1897 : DOI : 10.1002/slct.201703013
Marius Mamone, Jessy Aziz, Julie Le Bescont, Sandrine Piguel (2018 Jan 18)

Aminocarbonylation of N-Containing Heterocycles with Aromatic Amines Using Mo(CO)6

Synthesis : 50 : A-F : DOI : 10.1055/s-0037-1609152
Hammerer F., Poyer F., Fourmois L., Chen S., Garcia G., Teulade-Fichou M.P., Maillard P., Mahuteau-Betzer F. (2018 Jan 1)

Mitochondria-targeted cationic porphyrin-triphenylamine hybrids for enhanced two-photon photodynamic therapy

Bioorganic & Medicinal Chemistry : 26 : 107-118 : DOI : 10.1016/j.bmc.2017.11.024
Verguet A., Messaoudi C., Sorzano C.O.S., Marco S. (2018 Jan 1)

Alignment of Tilt Series

Cellular Imaging : 183-207 : DOI : 10.1007/978-3-319-68997-5