UMR9187 / U1196 – Chemistry, Modelling and Imaging for Biology (CMIB)

The central activity of the CMIB unit is to develop small molecules to probe and control the biological activities of key targets involved in cancer.

These are mainly non-B nucleic acid structures (Quadruplexes) and Kinases. IR-photoexcitable probes designed both for subcellular tracking and targeted photodamage represents also an important research axis. The drug and probe discovery activity is sustained by Molecular Modelling approaches and Multimodal Imaging (TEM, NanoSIMS, IRM). The CMIB unit is hosting the Institut Curie–CNRS proprietary library comprised of over 9000 chemical compounds and the preclinical IRM imaging and chemical imaging facilities

The main research themes of the unit include:

  • G-quadruplex targeting agents
  • DNA targeted fluorescent dyes
  • Kinase inhibitors
  • Photo and radiosensitizers for Retinoblastoma and Glioblastoma therapy.
  • Medicinal chemistry (Hit to lead optimization, building of focused libraries)
  • Molecular dynamics and virtual screening
  • Multimodal imaging for 2D and 3D chemical mapping
  • Development of software and Image acquisition, processing and analysis

Key publications

Year of publication 2017

Donati L., Nilchian M., Trepout S., Messaoudi C., Marco S., Unser M. (2017 Aug 1)

Compressed sensing for STEM tomography

ULTRAMICROSCOPY : 179 : 47-56 : DOI : 10.1016/j.ultramic.2017.04.003
Marie-Paule Teulade-Fichou, Joël Lefebvre, Corinne Guetta, Florent Poyer, Florence Mahuteau-Betzer (2017 Jul 13)

Copper-alkyne complexation is responsible for the Nucleolar Localisation of Quadruplex Nucleic Acid Drugs Labelled by Click Chemistry.

Angewandte Chemie (International ed. in English) : Online publication : DOI : 10.1002/anie.201703783
Chennoufi R., Mahuteau-Betzer F., Tauc P., Teulade-Fichou M.P., Deprez E. (2017 Jun 18)

Triphenylamines Induce Cell Death Upon 2-Photon Excitation

MOLECULAR IMAGING : 16 : DOI : 10.1177/1536012117714164
Stéphanie Lemaitre, Florent Poyer, Sergio Marco, Paul Fréneaux, François Doz, Isabelle Aerts, Laurence Desjardins, Nathalie Cassoux, Carole D Thomas (2017 Jun 17)

Looking for the Most Suitable Orthotopic Retinoblastoma Mouse Model in Order to Characterize the Tumoral Development.

Investigative ophthalmology & visual science : 58 : 3055-3064 : DOI : 10.1167/iovs.17-21760
Chaput L., Mouawad L. (2017 Jun 12)

Efficient conformational sampling and weak scoring in docking programs? Strategy of the wisdom of crowds

JOURNAL OF CHEMINFORMATICS : 9 : DOI : 10.1186/s13321-017-0227-x
Aroune D., Libdiri F., Leboucher S., Maouche B., Marco S., El-Aoufi S. (2017 May 1)

Changes in the NF kappa B and E-cadherin expression are associated to diabetic nephropathy in Psammomys obesus

SAUDI JOURNAL OF BIOLOGICAL SCIENCES : 24 : 843-850 : DOI : 10.1016/j.sjbs.2016.05.009