UMR9187 / U1196 – Chemistry, Modelling and Imaging for Biology (CMIB)

Post Doctoral fellow position in Chemical Biology of Nucleic Acids

A two-years post-doctoral position is currently available in the laboratory of Chemistry, Modelling and Imaging for Biology (CMIB) In the team of Dr. Marie-Paule Teulade-Fichou (http// Institut Curie. The laboratory is located at the research center of the Institut Curie on the campus of Orsay (Paris-Saclay University- south of Paris, France). Read more …

The central activity of the CMIB unit is to develop small molecules to probe and control the biological activities of key targets involved in cancer (These are mainly non-B nucleic acid structures (Quadruplexes) and Kinases).

IR-photoexcitable probes designed both for subcellular tracking and targeted photodamage represents also an important research axis. The drug and probe discovery activity is sustained by Molecular Modelling approaches and Multimodal Imaging (TEM, NanoSIMS, IRM). The CMIB unit is hosting the Institut Curie–CNRS proprietary library comprised of over 9000 chemical compounds and the preclinical IRM imaging and chemical imaging facilities

The main research themes of the unit include:

  • G-quadruplex targeting agents
  • DNA targeted fluorescent dyes
  • Kinase inhibitors
  • Photo and radiosensitizers for Retinoblastoma and Glioblastoma therapy.

The main methodological approaches are :

  • Chemical biology and medicinal chemistry (Hit to lead optimization)
  • Molecular dynamics and virtual screening
  • Multimodal imaging for 2D and 3D chemical mapping
  • Development of software and Image acquisition, processing and analysis

Key publications

Year of publication 2018

Morgan Pellerano, Delphine Naud-Martin, Florence Mahuteau-Betzer, Marie Morille, May Catherine Morris (2018 Dec 13)

Fluorescent biosensor for detection of the R248Q aggregation-prone mutant of p53.

Chembiochem : a European journal of chemical biology : Accepted Author Manuscript : DOI : 10.1002/cbic.201800531
Michela Zuffo, Xiao Xie, Anton Granzhan (2018 Dec 6)

Strength in Numbers: Development of a Fluorescence Sensor Array for Secondary Structures of DNA.

Chemistry - A European Journal : DOI : 10.1002/chem.201805422
Coralie Caron, Xuan N T Duong, Régis Guillot, Sophie Bombard, Anton Granzhan (2018 Dec 4)

Interaction of Functionalized Naphthalenophanes with Abasic Sites in DNA: DNA Cleavage, DNA Cleavage Inhibition, and Formation of Ligand-DNA Adducts.

Chemistry - A European Journal : DOI : 10.1002/chem.201805555
Partouche D., Turbant F., El Hamoui O., Campidelli C., Bombled M., Trépout S., Wien F., Arluison V. (2018 Dec 1)

Epigallocatechin Gallate Remodelling of Hfq Amyloid-Like Region Affects Escherichia coli Survival

Pathogens : 7 : 95 : DOI : 10.3390/pathogens7040095
Prado Martins R., Findakly S., Daskalogianni C., Teulade-Fichou M.P., Blondel M., Fåhraeus R. (2018 Nov 29)

In Cellulo Protein-mRNA Interaction Assay to Determine the Action of G-Quadruplex-Binding Molecules

Molecules : 23 : 3124 : DOI : 10.3390/molecules23123124
Verga D., Nguyen C.H., Dakir M., Coll J.L., Teulade-Fichou M.P., Molla A. (2018 Nov 20)

Polyheteroaryl Oxazole/Pyridine-based compounds selected in vitro as G-quadruplex ligands inhibit Rock kinase and exhibit antiproliferative activity

Journal of Medicinal Chemistry : Just Accepted Manuscript : DOI : 10.1021/acs.jmedchem.8b01023