UMR9187 / U1196 – Chemistry, Modelling and Imaging for Biology (CMIB)

The central activity of the CMIB unit is to develop small molecules to probe and control the biological activities of key targets involved in cancer (These are mainly non-B nucleic acid structures (Quadruplexes) and Kinases).

IR-photoexcitable probes designed both for subcellular tracking and targeted photodamage represents also an important research axis. The drug and probe discovery activity is sustained by Molecular Modelling approaches and Multimodal Imaging (TEM, NanoSIMS, IRM). The CMIB unit is hosting the Institut Curie–CNRS proprietary library comprised of over 9000 chemical compounds and the preclinical IRM imaging and chemical imaging facilities

The main research themes of the unit include:

  • G-quadruplex targeting agents
  • DNA targeted fluorescent dyes
  • Kinase inhibitors
  • Photo and radiosensitizers for Retinoblastoma and Glioblastoma therapy.

The main methodological approaches are :

  • Chemical biology and medicinal chemistry (Hit to lead optimization)
  • Molecular dynamics and virtual screening
  • Multimodal imaging for 2D and 3D chemical mapping
  • Development of software and Image acquisition, processing and analysis

Key publications

Year of publication 2019

Ouahiba Sihali-Beloui, Djamila Aroune, Fella Benazouz, Adile Hadji, Salima El-Aoufi, Sergio Marco (2019 Jun 2)

A hypercaloric diet induces hepatic oxidative stress, infiltration of lymphocytes, and mitochondrial reshuffle in Psammomys obesus, a murine model of insulin resistance.

Comptes rendus biologies : DOI : S1631-0691(19)30041-1
Dapeng Zhang, Yujiao Fan, Hui Chen, Sylvain Trépout, Min-Hui Li (2019 May 31)

CO2-activated reversible transition between polymersomes and micelles with AIE fluorescence.

Angewandte Chemie (International ed. in English) : Accepted Author Manuscript : DOI : 10.1002/anie.201905089
Oksana Reznichenko, Alicia Quillévéré, Rodrigo Prado Martins, Nadège Loaëc, Hang Kang, María José Lista, Claire Beauvineau, Jorge González-García, Régis Guillot, Cécile Voisset, Chrysoula Daskalogianni, Robin Fåhraeus, Marie-Paule Teulade-Fichou, Marc Blondel, Anton Granzhan (2019 May 23)

Novel cationic bis(acylhydrazones) as modulators of Epstein–Barr virus immune evasion acting through disruption of interaction between nucleolin and G-quadruplexes of EBNA1 mRNA

European Journal of Medicinal Chemistry : 178 : 13-29 : DOI : 10.1016/j.ejmech.2019.05.042
Emilia Puig Lombardi, Allyson Holmes, Daniela Verga, Marie-Paule Teulade-Fichou, Alain Nicolas, Arturo Londoño-Vallejo (2019 May 23)

Thermodynamically stable and genetically unstable G-quadruplexes are depleted in genomes across species.

Nucleic acids research : gkz463 : 2019-2020 : DOI : 10.1093/nar/gkz463
El Hassen Mokrani, Abderrahmane Bensegueni, Ludovic Chaput, Claire Beauvineau, Hanane Djeghim, Liliane Mouawad (2019 May 1)

Identification of New Potent Acetylcholinesterase Inhibitors Using Virtual Screening and In Vitro Approaches.

Molecular informatics : 38 : 1800118 : DOI : 10.1002/minf.201800118
David Partouche, Jérémie Mathurin, Antoine Malabirade, Sergio Marco, Christophe Sandt, Véronique Arluison, Ariane Deniset-Besseau, Sylvain Trépout (2019 Apr 1)

Correlative infrared nanospectroscopy and transmission electron microscopy to investigate nanometric amyloid fibrils: prospects and challenges.

Journal of microscopy : 274 : 23-31 : DOI : 10.1111/jmi.12779