UMR9187 / U1196 – Chemistry, Modelling and Imaging for Biology (CMIB)

The central activity of the CMIB unit is to develop small molecules to probe and control the biological activities of key targets involved in cancer.

These are mainly non-B nucleic acid structures (Quadruplexes) and Kinases. IR-photoexcitable probes designed both for subcellular tracking and targeted photodamage represents also an important research axis. The drug and probe discovery activity is sustained by Molecular Modelling approaches and Multimodal Imaging (TEM, NanoSIMS, IRM). The CMIB unit is hosting the Institut Curie–CNRS proprietary library comprised of over 9000 chemical compounds and the preclinical IRM imaging and chemical imaging facilities

The main research themes of the unit include:

  • G-quadruplex targeting agents
  • DNA targeted fluorescent dyes
  • Kinase inhibitors
  • Photo and radiosensitizers for Retinoblastoma and Glioblastoma therapy.
  • Medicinal chemistry (Hit to lead optimization, building of focused libraries)
  • Molecular dynamics and virtual screening
  • Multimodal imaging for 2D and 3D chemical mapping
  • Development of software and Image acquisition, processing and analysis

Key publications

Year of publication 2017

Slodzian G., Wu T.D., Duprat J., Engrand C., Guerquin-Kern J.L. (2017 Dec 1)

Dynamic transfer applied to secondary ion imaging over large scanned fields with the nanoSIMS 50 at high mass resolution

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms : 412 : 123-173 : DOI : 10.1016/j.nimb.2017.06.019
Hammerer F., Poyer F., Fourmois L., Chen S., Garcia G., Teulade-Fichou M.P., Maillard P., Mahuteau-Betzer F. (2017 Nov 15)

Mitochondria-targeted cationic porphyrin-triphenylamine hybrids for enhanced two-photon photodynamic therapy

Bioorganic & Medicinal Chemistry : In press : DOI : https://doi.org/10.1016/j.bmc.2017.11.024
Ludivine Guyon, Marc Pirrotta, Katerina Duskova, Anton Granzhan, Marie-Paule Teulade-Fichou, David Monchaud (2017 Nov 15)

TWJ-Screen: an isothermal screening assay to assess ligand/DNA junction interactions in vitro

Nucleic Acids Research : gkx1118 : DOI : 10.1093/nar/gkx1118
Chiara Mauriello-Jimenez, Maxime Henry, Dina Aggad, Laurence Raehm, Xavier Cattoën, Michel Wong Chi Man, Clarence Charnay, Serkan Alpugan, Vefa Ahsen, Deniz Kutlu Tarakci, Philippe Maillard, Marie Maynadier, Marcel Garcia, Fabienne Dumoulin, Magali Gary-Bobo, Jean-Luc Coll, Véronique Josserand, Jean-Olivier Durand (2017 Oct 31)

Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles for two-photon photodynamic therapy or photoacoustic imaging.

Nanoscale : DOI : 10.1039/c7nr04677d
Pabon-Martinez Y.V., Xu Y., Villa A., Lundin K.E., Geny S., Nguyen C.H., Pedersen E.B., Jorgensen P.T., Wengel J., Nilsson L., Smith C.I.E., Zain R. (2017 Sep 8)

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures

SCIENTIFIC REPORTS : 7 : DOI : 10.1038/s41598-017-09147-8
Antoine Malabirade, Javier Morgado-Brajones, Sylvain Trépout, Frank Wien, Ileana Marquez, Jérôme Seguin, Sergio Marco, Marisela Velez, Véronique Arluison (2017 Sep 8)

Membrane association of the bacterial riboregulator Hfq and functional perspectives.

Scientific reports : 7 : 10724 : DOI : 10.1038/s41598-017-11157-5