UMR9187 / U1196 – Chemistry, Modelling and Imaging for Biology (CMIB)

The central activity of the CMIB unit is to develop small molecules to probe and control the biological activities of key targets involved in cancer.

These are mainly non-B nucleic acid structures (Quadruplexes) and Kinases. IR-photoexcitable probes designed both for subcellular tracking and targeted photodamage represents also an important research axis. The drug and probe discovery activity is sustained by Molecular Modelling approaches and Multimodal Imaging (TEM, NanoSIMS, IRM). The CMIB unit is hosting the Institut Curie–CNRS proprietary library comprised of over 9000 chemical compounds and the preclinical IRM imaging and chemical imaging facilities

The main research themes of the unit include:

  • G-quadruplex targeting agents
  • DNA targeted fluorescent dyes
  • Kinase inhibitors
  • Photo and radiosensitizers for Retinoblastoma and Glioblastoma therapy.
  • Medicinal chemistry (Hit to lead optimization, building of focused libraries)
  • Molecular dynamics and virtual screening
  • Multimodal imaging for 2D and 3D chemical mapping
  • Development of software and Image acquisition, processing and analysis

Key publications

Year of publication 2017

Antoine Malabirade, Javier Morgado-Brajones, Sylvain Trépout, Frank Wien, Ileana Marquez, Jérôme Seguin, Sergio Marco, Marisela Velez, Véronique Arluison (2017 Sep 8)

Membrane association of the bacterial riboregulator Hfq and functional perspectives.

Scientific reports : 7 : 10724 : DOI : 10.1038/s41598-017-11157-5
Pauline Gilson, Fernando Josa-Prado, Claire Beauvineau, Delphine Naud-Martin, Laetitia Vanwonterghem, Florence Mahuteau-Betzer, Alexis Moreno, Pierre Falson, Laurence Lafanechère, Véronique Frachet, Jean-Luc Coll, Jose Fernando Díaz, Amandine Hurbin, Benoit Busser (2017 Sep 2)

Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer properties.

Scientific reports : 10209 : DOI : 10.1038/s41598-017-09491-9
Sylvain Trépout, Anne Marie Wehenkel (2017 Aug 31)

Bacterial Tubulins: A Eukaryotic-Like Microtubule Cytoskeleton

Trends in Microbiology : In press, corrected proof : DOI : 10.1016/j.tim.2017.08.004
Buchieri Maria V., Cimino Mena , Rebollo-Ramirez Sonia, Beauvineau Claire, Cascioferro Alessandro, Favre-Rochex Sandrine, Helynck Olivier, Naud-Martin Delphine, Larrouy-Maumus Gerald, Munier-Lehmann Hélène, Gicquel Brigitte (2017 Aug 28)

Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis

Journal of Medicinal Chemistry : DOI : 10.1021/acs.jmedchem.7b00726
Aziza Jessy, Piguel Sandrine (2017 Aug 25)

An update on direct C–H bond functionalization of nitrogen-containing fused heterocycles

Synthesis : 49 : DOI : 10.1055/s-0036-1590859
Claire Beauvineau, Corinne Guetta, Marie-Paule Teulade-Fichou, Florence Mahuteau-Betzer (2017 Aug 14)

PhenDV, a turn-off fluorescent quadruplex DNA probe for improving the sensitivity of drug screening assays

Organic & Biomolecular Chemistry : 15 : 7117-7121 : DOI : 10.1039/c7ob01705g