UMR3664 – Nuclear Dynamics

logos


Teams in this unit investigate the mechanisms underlying the stability and the plasticity of genetic and epigenetic information in normal or pathological contexts such as cancer. Using complementarity approaches, we develop an integrated view of the functional organization of the genome at different scales: from the molecule to the cell to the organism.

Using several model organisms (Drosophila, Xenopus, mouse, yeast) and cell lines (human, rodents, insects …) we study fundamental processes of chromosome biology: DNA replication, segregation and repair, regulation of gene expression during development, cell cycle and in response to environmental stress

Together, these models are helping to decipher how DNA replication and repair, gene transcription and silencing  are modulated during development, cell division and in response to environmental stress

The main research themes of the unit include:

  • The roles of factors involved in chromatin dynamics, genome stability and repair
  • How functional domains of eukaryotic genomes are established and then maintained during development.
  • How epigenetic plasticity plays a part in controlling the polarity of the embryo.
  • How nuclear compartmentalisation and dynamics participate in regulating various functions of the genome.

 

Key publications

Year of publication 2016

Sebastian Müller, Geneviève Almouzni (2016 Dec 1)

Chromatin dynamics during the cell cycle at centromeres.

Nature Reviews Genetics : 192-208 : DOI : 10.1038/nrg.2016.157
Christèle Maison, Delphine Bailly, Jean-Pierre Quivy, Geneviève Almouzni (2016 Jul 19)

The methyltransferase Suv39h1 links the SUMO pathway to HP1α marking at pericentric heterochromatin.

Nature communications : 12224 : DOI : 10.1038/ncomms12224
Lisa Prendergast, Sebastian Müller, Yiwei Liu, Hongda Huang, Florent Dingli, Damarys Loew, Isabelle Vassias, Dinshaw J Patel, Kevin F Sullivan, Geneviève Almouzni (2016 Jun 11)

The CENP-T/-W complex is a binding partner of the histone chaperone FACT.

Genes & development : 1313-26 : DOI : 10.1101/gad.275073.115
A Coulon, D R Larson (2016 Jun 1)

Fluctuation Analysis: Dissecting Transcriptional Kinetics with Signal Theory.

Methods in enzymology : 159-91 : DOI : 10.1016/bs.mie.2016.03.017
Cédric Delevoye, Xavier Heiligenstein, Léa Ripoll, Floriane Gilles-Marsens, Megan K Dennis, Ricardo A Linares, Laura Derman, Avanti Gokhale, Etienne Morel, Victor Faundez, Michael S Marks, Graça Raposo (2016 Jan 4)

BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes.

Current biology : CB : 1-13 : DOI : 10.1016/j.cub.2015.11.020
Topkaya D., Lafont D., Poyer F., Garcia G., Albrieux F., Maillard P., Bretonniere Y., Dumoulin F. (2016 Jan 1)

Design of an amphiphilic porphyrin exhibiting high in vitro photocytotoxicity

NEW JOURNAL OF CHEMISTRY : 40 : 2044-2050 : DOI : 10.1039/c5nj02716k