Unit
Dynamics of Genetic Information: fundamental bases and cancer (DIG-Cancer) (UMR3244)
Thematic areas of research:
Image
To top
Unit
ANTONIN MORILLON / VALERIE BORDE
Dynamics of Genetic Information: fundamental bases and cancer (DIG-Cancer) (UMR3244)
The teams in this unit aim to better understand the mechanisms that maintain genome and epigenome integrity and expression and study how disruptions in these processes contribute to cancers and age-related human diseases.
Teams
Key figures
123
Publications since 2019
4
ERC since 2019
3
Spin-off since 2019
Key publications
All publications
-
-
-
Multi-modal quantification of pathway activity with MAYANature Communications
-
-
Kronos scRT: a uniform framework for single-cell replication timing analysisNature Communications
-
-
-
Molecular basis of the dual role of the Mlh1-Mlh3 endonuclease in MMR and in meiotic crossover formationProceedings of the National Academy of Sciences
-
Interactive analysis of single-cell epigenomic landscapes with ChromSCapeNature Communications
-
News
All news
-
World Triple Negative Breast Cancer Day: innovation to cure more womenWorld Triple Negative Breast Cancer Day, held on March 3rd, is a reminder that triple-negative breast cancers remain the most difficult to treat, and that only innovation and dynamic research can bring hope of curing more patients.01/03/2024
-
L’Institut Curie engagé sur le front des cancers masculinsEn novembre, mois de sensibilisation aux cancers masculins, l’Institut Curie met en lumière les spécificités de ces cancers. Ses trois sites, Paris, Saint-Cloud et Orsay, offrent à chaque patient une prise en charge optimale des cancers de la prostate, des testicules et du pénis, ainsi qu’un accès à l’innovation. Côté recherche, les équipes s’intéressent aux aspects biologiques et physiologiques de ces maladies.03/11/2023
-
Institut Curie’s latest progress at the AACR Annual Meeting 2023From April 14 to 19, 2023, in Orlando, USA, the international scientific and medical community comes together for the annual meeting of the American Association for Cancer Research, an opportunity for scientists from Institut Curie to present their findings in various fields of cancer research.17/04/2023
-
Institut Curie certified as Integrated cancer research site for the third timeFollowing a call for applications launched in April 2022, Institut Curie had its integrated cancer research site project certified by France’s Institut national du cancer (Inca). Its goal is to better understand tumor recurrences in order to better prevent, detect and treat them.20/02/2023
-
Unprecedented: a team from Institut Curie discovers how DNA unzips at the time of replicationAn article published in Cell and co-authored by Chunlong Chen, head of the Replication program and genome instability team at Institut Curie, reports an unprecedented discovery on DNA replication. It helps us better understand how life is created and gives hope for progress in oncology.
Since the discovery of the structure of the double DNA helix in 1953, the way in which double09/01/2023 -
Chunlong Chen, first Institut Curie’s recipient of the Fondation Bettencourt Schueller Impulscience program.The Fondation Bettencourt Schueller has chosen the research project of Chunlong Chen, group leader at Institut Curie Research Center, as one of seven recipients of its new research support program, Impulscience. This funding should allow him to extend his work in fundamental biology on the regulation of DNA replication, as well as genome transcription.28/11/2022
Scientific events
"How homologous recombination (HR)-deficient tumors survive genomic instability"
Abstract
Gaining recognition in the last few years, alternative DNA repair pathways were recently shown to be required for cancer cell viability in the absence of homologous recombination (HR)-mediated DNA repair. Deciphering the functions and composition of these pathways will facilitate
All scientific events
31 May
2024
Seminar
11h-12h
Cutting and Pasting DNA to Create our Adaptive Immune System
V(D)J recombination is essential for generating the adaptive immune response and unlimited number of different antibodies and antigen receptors. Encoded by multiple V, D and J gene segments, antigen receptors are assembled by programmed double-stranded DNA cleavage and imprecise re-joining. RAG1/2 recombinase initiates the process by stochastically cleaving DNA at a pair of recombination signal se
5 Apr
2024
Institutional seminar "Mayent - Rothschild"
11h-12h
A garden of forking paths: branching, switching and reversal in meiotic recombination
Abstract
Meiotic recombination involves repair of double strand DNA breaks by homologous recombination to form crossovers and noncrossovers. Current models suggest that different mechanisms form these two products: noncrossovers by synthesis dependent strand annealing; COs by double Holliday junction formation and resolution. In testing these predictions, we found evidence for remarkable dynami
Meiotic recombination involves repair of double strand DNA breaks by homologous recombination to form crossovers and noncrossovers. Current models suggest that different mechanisms form these two products: noncrossovers by synthesis dependent strand annealing; COs by double Holliday junction formation and resolution. In testing these predictions, we found evidence for remarkable dynami
22 Mar
2024
Seminar
11h-23h
Initiation of DNA replication visualised by cryo-EM
Activation of eukaryotic origins of replication occurs in temporally separated steps to ensure that chromosomes are copied only once per cell cycle. First, the MCM helicase is loaded onto duplex DNA as an inactive double hexamer. The loaded form of the MCM is selectively phosphorylated by the Dbf4-dependent kinase. This event facilitates the assembly of two Cdc45-MCM-GINS (CMG) holo-helicase
11 Mar
2024
Symposium
08h-17h
"Genetics together with the next-generation" - A Symposium to celebrate the career of Alain Nicolas
The symposium "Genetics together with the next-generation" will honor the career of Alain Nicolas, dedicated to the study of the mechanisms of genome maintenance and inter-generational transmission. Beyond his numerous scientific contributions, Alain has also contributed to training an important new generation of scientists, gathering the international scientific community through the or
8 Jan
2024
Seminar
11h-23h
Double Raphael - Double Trouble - Double Impact
"How homologous recombination (HR)-deficient tumors survive genomic instability"
Abstract
Gaining recognition in the last few years, alternative DNA repair pathways were recently shown to be required for cancer cell viability in the absence of homologous recombination (HR)-mediated DNA repair. Deciphering the functions and composition of these pathways will facilitate