Private: Mammalian Developmental Epigenetics

Team Members

Anne-Valerie Gendrel


Anne-Valerie Gendrel Team Heard Researcher Tel: Back to the list

Research Interests:

Maintenance of X-chromosome inactivation

DNA methylation


Monoallelic expression

Repeats and transposable elements regulation


mini CV:

Since Oct 2014 Inserm research scientist (CR1)

2009-2014  Postdoc in Edith Heard's group; Institut Curie, Paris, France.

2005-2009  Postdoc in Neil Brockdorff’s group; MRC Clinical Sciences Centre, London, UK.

2005  PhD in Genetics, Université Paris XI, Orsay, France. Supervision by Dr Vincent Colot; Epigenetic regulation of transposable elements and its impact on the genome in the model plant Arabidopsis thaliana.


Selected publications:

Gendrel A-V., Attia M., Chen C-J., Diabangouaya P., Servant N., Barillot E. and Heard E. Developmental dynamics and disease potential of random monoallelic gene expression. (2014). Developmental Cell, 28(4):366-80.

Corbel C., Diabangouaya P., Gendrel A-V., Chow J.C., and Heard E. (2013). Unusual chromatin status and organisation of the inactive X chromosome in murine trophoblast giant cells. Development, 140(4):861-72.

Gendrel A-V., Tang Y.A., Suzuki M., Godwin J., Nesterova T.B., Greally J.M., Heard E., and Brockdorff N. (2013). Epigenetic functions of Smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Mol Cell Biol, 33(16):3150-65.

Gendrel A-V., Apedaile A., Termanis A, Coker H., Zvetkova I., Godwin J, Tang YA., Huntley D., Montana G., Taylor S, Giannoulatou E, Heard E, Stancheva S, and Brockdorff, N. (2012). Smchd1 dependent and independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome. Developmental Cell, 23(2):265-79.

Gendrel A-V. and Heard E. (2011). Fifty years of X-inactivation research. Development, 138(23):5049-55.

Blewitt M.E., Gendrel A-V., Pang Z., Sparrow D.B., Whitelaw N., Craig J.M., Apedaile A., Hilton D.J., Dunwoodie S.L., Brockdorff N., Kay G.F., and Whitelaw E. (2008). SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Nature Genetics, 40(5):663-9.

Key publications

Year of publication 2014

Anne-Valerie Gendrel, Mikael Attia, Chong-Jian Chen, Patricia Diabangouaya, Nicolas Servant, Emmanuel Barillot, Edith Heard (2014 Feb 24)

Developmental dynamics and disease potential of random monoallelic gene expression.

Developmental cell : 366-80 : DOI : 10.1016/j.devcel.2014.01.016