Polarity Division Morphogenesis

Team Members

Yohanns Bellaïche, PhD

Yohanns Bellaiche

Yohanns Bellaïche CNRS Research Director Team Bellaïche Unit Deputy Director Team Leader Tel:

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Research Activities

Deputy Director of the “Genetics and Developmental Biology Unit” Since Jan 2011
UMR 3215-U934 ,Curie Institute, Paris, France

Senior Group Leader “Polarity Division Morphogenesis team Since 2008
“Genetics and Developmental Biology Unit” CNRS U3215 INSERM U934
Curie Institute, Paris (France).
Unit of Dr. Edith Heard (since 2010) and Prof. S. Artavanis Tsakonas (2008-2010)

Junior Group Leader 2003 - 2008
CNRS ATIPE, UMR144, Curie Institute, Paris (France). Unit of Dr. B. Goud.

Postdoctoral Fellow 1998 - 2003
Ecole Normale Supérieure, Paris. France. Laboratory of Dr. F. Schweisguth.

PhD thesis 1995 - 1998
Harvard Medical School, Boston. USA. Laboratory of Dr. N. Perrimon.

Academic Diplomas

PhD, University Paris 6, Biology, 1998

Masters’ degree, Ecole Normale Supérieure de Lyon, Molecular and Cellular Biology, 1993

Prizes and Awards

  • Elected as EMBO member (2012)
  • Young Investigator EMBO Award (2005)
  • CNRS Bronze Medal Award (2002)
  • Paoletti Award (2002)

actuals finance

  • ANR-14-BLANC, 178 000€, 2014-2018.
  • ARC Programme labélisé 2013, 300 000€, 2013-2016.
  • ERC Advanced Grant 2 419 000€, 2014-2019

Key publications

Year of publication 2020

Jesús M López-Gay, Hayden Nunley, Meryl Spencer, Florencia di Pietro, Boris Guirao, Floris Bosveld, Olga Markova, Isabelle Gaugue, Stéphane Pelletier, David K Lubensky, Yohanns Bellaïche (2020 Oct 16)

Apical stress fibers enable a scaling between cell mechanical response and area in epithelial tissue.

Science (New York, N.Y.) : DOI : eabb2169

Year of publication 2018

Diana Pinheiro, Yohanns Bellaïche (2018 Oct 10)

Mechanical Force-Driven Adherens Junction Remodeling and Epithelial Dynamics.

Developmental cell : 3-19 : DOI : S1534-5807(18)30743-3
Zhimin Wang, Floris Bosveld, Yohanns Bellaïche (2018 May 10)

Tricellular junction proteins promote disentanglement of daughter and neighbour cells during epithelial cytokinesis.

Journal of cell science : DOI : jcs215764

Year of publication 2017

Diana Pinheiro, Edouard Hannezo, Sophie Herszterg, Floris Bosveld, Isabelle Gaugue, Maria Balakireva, Zhimin Wang, Inês Cristo, Stéphane U Rigaud, Olga Markova, Yohanns Bellaïche (2017 Mar 16)

Transmission of cytokinesis forces via E-cadherin dilution and actomyosin flows.

Nature : DOI : 10.1038/nature22041

Year of publication 2016

Floris Bosveld, Olga Markova, Boris Guirao, Charlotte Martin, Zhimin Wang, Anaëlle Pierre, Maria Balakireva, Isabelle Gaugue, Anna Ainslie, Nicolas Christophorou, David K Lubensky, Nicolas Minc, Yohanns Bellaïche (2016 Feb 18)

Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis.

Nature : 495-8 : DOI : 10.1038/nature16970

Year of publication 2015

Boris Guirao, Stéphane U Rigaud, Floris Bosveld, Anaïs Bailles, Jesús López-Gay, Shuji Ishihara, Kaoru Sugimura, François Graner, Yohanns Bellaïche (2015 Dec 15)

Unified quantitative characterization of epithelial tissue development.

eLife : DOI : 10.7554/eLife.08519
Floris Bosveld, Boris Guirao, Zhimin Wang, Mathieu Rivière, Isabelle Bonnet, François Graner, Yohanns Bellaïche (2015 Jul 5)

Modulation of junction tension by tumor suppressors and proto-oncogenes regulates cell-cell contacts.

Development (Cambridge, England) : 623-34 : DOI : 10.1242/dev.127993

Year of publication 2013

Pierre-Luc Bardet, Boris Guirao, Camille Paoletti, Fanny Serman, Valentine Léopold, Floris Bosveld, Yûki Goya, Vincent Mirouse, François Graner, Yohanns Bellaïche (2013 May 28)

PTEN controls junction lengthening and stability during cell rearrangement in epithelial tissue.

Developmental cell : 534-46 : DOI : 10.1016/j.devcel.2013.04.020
Sophie Herszterg, Andrea Leibfried, Floris Bosveld, Charlotte Martin, Yohanns Bellaiche (2013 Feb 16)

Interplay between the dividing cell and its neighbors regulates adherens junction formation during cytokinesis in epithelial tissue.

Developmental cell : 256-70 : DOI : 10.1016/j.devcel.2012.11.019

Year of publication 2012

Floris Bosveld, Isabelle Bonnet, Boris Guirao, Sham Tlili, Zhimin Wang, Ambre Petitalot, Raphaël Marchand, Pierre-Luc Bardet, Philippe Marcq, François Graner, Yohanns Bellaïche (2012 Apr 14)

Mechanical control of morphogenesis by Fat/Dachsous/Four-jointed planar cell polarity pathway.

Science (New York, N.Y.) : 724-7 : DOI : 10.1126/science.1221071

Year of publication 2010

Marion Ségalen, Christopher A Johnston, Charlotte A Martin, Julien G Dumortier, Kenneth E Prehoda, Nicolas B David, Chris Q Doe, Yohanns Bellaïche (2010 Apr 19)

The Fz-Dsh planar cell polarity pathway induces oriented cell division via Mud/NuMA in Drosophila and zebrafish.

Developmental cell : 740-52 : DOI : 10.1016/j.devcel.2010.10.004
Maria-Isabel Yuseff, Anne Reversat, Danielle Lankar, Jheimmy Diaz, Isabelle Fanget, Paolo Pierobon, Violaine Randrian, Nathanael Larochette, Fulvia Vascotto, Chantal Desdouets, Bertrand Jauffred, Yohanns Bellaiche, Stéphane Gasman, François Darchen, Claire Desnos, Ana-Maria Lennon-Duménil (2010 Mar 11)

Polarized secretion of lysosomes at the B cell synapse couples antigen extraction to processing and presentation.

Immunity : 361-74 : DOI : 10.1016/j.immuni.2011.07.008

Year of publication 2008

Pierre Fichelson, Clara Moch, Kenzo Ivanovitch, Charlotte Martin, Clara M Sidor, Jean-Antoine Lepesant, Yohanns Bellaiche, Jean-René Huynh (2008 Nov 14)

Live-imaging of single stem cells within their niche reveals that a U3snoRNP component segregates asymmetrically and is required for self-renewal in Drosophila.

Nature cell biology : 685-93 : DOI : 10.1038/ncb1874

Year of publication 2006

Maria Balakireva, Carine Rossé, Johanna Langevin, Yu-chen Chien, Michel Gho, Geneviève Gonzy-Treboul, Stéphanie Voegeling-Lemaire, Sandra Aresta, Jean-Antoine Lepesant, Yohanns Bellaiche, Michael White, Jacques Camonis (2006 Sep 25)

The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster.

Molecular and cellular biology : 8953-63

Year of publication 2005

Nicolas B David, Charlotte A Martin, Marion Segalen, François Rosenfeld, François Schweisguth, Yohanns Bellaïche (2005 Oct 18)

Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell division.

Nature cell biology : 1083-90
Johanna Langevin, Matthew J Morgan, Jean-Baptiste Sibarita, Sandra Aresta, Mala Murthy, Thomas Schwarz, Jacques Camonis, Yohanns Bellaïche (2005 Oct 15)

Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane.

Developmental cell : 365-76