Thematic areas of research:
Image
To top
Unit
Genetics and Developmental Biology (UMR3215 / U934)
The research Unit “Genetics and Developmental Biology” of Institut Curie is composed of nine teams addressing fundamental questions related to the development of organisms and its pathological dysfunctions.
Teams
Key figures
16
publications in 2020
3
ongoing ERC in 2020
24
PhD Students in 2020
Key publications
All publications
-
Brain adiponectin signaling controls peripheral insulin response in DrosophilaNature Communications
-
-
-
-
-
News
All news
-
Congratulations to Dr. Jean-Léon Maître, recipient of the Richard Lounsbery AwardDr. Jean-Léon Maître, head of the Mechanics of Mammalian Development team, has been honored with the prestigious Richard Lounsbery Award by the French Academy of Sciences and the American National Academy of Sciences (NAS). The award recognizes the research carried out by his team to understand the mechanisms underlying the construction of the mammalian embryo.15/03/2024 -
Embryo fragmentation under the microscopeDuring the early days of its existence, cells of human embryos may fragment. This phenomenon is common and affects the embryo’s survival. In a study published in EMBO Journal, researchers from CNRS and Institut Curie used a “light-sheet” microscope to discover that cell fragmentation is caused, in mouse models, by contractions on the surface of the embryo and occur when signals persist abnormally from when the maternal oocyte is formed.22/08/2023 -
Congratulations to Déborah Bourc’his, winner of an ERC Advanced GrantOn Thursday March 30, 2023, Déborah Bourc’his, team leader at Institut Curie’s Research Center, was awarded one of the European Research Council’s prestigious ERC Advanced Grants for her promising work on interactions between transposons and male reproductive cells.05/04/2023 -
Cell division and cell geometryThe mystery of reshaping of dividing epithelial cells’ cytoskeleton has mobilized the team led by Yohanns Bellaïche at Institut Curie’s Research Center. The results of their study, describing the essential role of small enzyme proteins - RhoGTPases - on the actomyosin cytoskeleton, have just been published in the journal Current Biology. A step towards better understanding of the process controlling the number of cells and the integrity of their genomes.17/03/2023 -
Morphogenesis: when genetics and mechanics work togetherThe spatial distribution of cells during embryonic development of an organism (morphogenesis) is affected in many diseases, including cancer. Yohanns Bellaïche and his Polarity, Division and Morphogenesis team at Institut Curie’s Research Center, in collaboration with a laboratory from Université Paris Cité, have just revealed a new mechanism involving tissue curvature and tension, controlled by genetics. Their results have just been published in the journal Nature Communications.13/03/2023 -
Institut Curie awarded yet another prestigious ERC grantThis Tuesday 31 January, Institut Curie Research Center biology researcher Jean-Léon Maître was awarded one of the European Research Council’s coveted grants. With two million Euros awarded over five years, the grant will allow the scientist to deepen our understanding of the physical forces at play in how the human body is structured.31/01/2023
Scientific events
All scientific events
25 Apr
2024
Seminar
16h-23h
Mechanics of Neural Crest Development: From Induction to Migration and Differentiation
The neural crest is an embryonic cell population whose migratory behavior has been likened to cancer invasion during metastasis. Neural crests differentiate into a wide array of cell types, including muscle, cartilage, bones, melanocytes, neurons, and glia. Although the role of mechanical cues has been demonstrated in the migration and differentiation of neural crest cells, little is known about w
11 Apr
2024
Institutional seminar "Mayent - Rothschild"
10h-23h
Mechanism of receptor choice in the olfactory system of ants
Bogdan Sieriebriennikov1,2, Hua Yan2 and Claude Desplan1
(1) NYU Biology, New York
(2) University of Florida, Gainesville
In both flies and vertebrates, smell is perceived by olfactory sensory neurons (OSNs) that rely on the expression of a single odorant receptor (Or) gene per cell to discriminate between odors. Flies have few Or genes (~60), while mammals have many (>1,000 in mice),
(1) NYU Biology, New York
(2) University of Florida, Gainesville
In both flies and vertebrates, smell is perceived by olfactory sensory neurons (OSNs) that rely on the expression of a single odorant receptor (Or) gene per cell to discriminate between odors. Flies have few Or genes (~60), while mammals have many (>1,000 in mice),
28 Mar
2024
Seminar
10h-23h
Spatiotemporal models of mammalian development: An epigeneticists dream or nightmare?
My research group aims to address the fundamental challenge of understanding how multicellular organisms achieve variation despite cells having identical genetic information. The development of a single fertilized egg into a complete mammalian embryo is an especially beautiful embodiment of this problem. During this process, cellular differentiation is defined by the capacity of the cell ensemble
29 Feb
2024
Seminar
10h-23h
Metabolism of neural stem cell-niche interactions
Metabolism of neural stem cell – niche interactions
While almost all eukaryotic cells require mitochondrial energy production, not all cells and tissues are equally susceptible to mitochondrial disease. In our lab, we mainly study how mitochondrial dysfunction and mutations in the mitochondrial genome affect neural stem cell (NSC) behaviour in Drosophila and mouse. Our
While almost all eukaryotic cells require mitochondrial energy production, not all cells and tissues are equally susceptible to mitochondrial disease. In our lab, we mainly study how mitochondrial dysfunction and mutations in the mitochondrial genome affect neural stem cell (NSC) behaviour in Drosophila and mouse. Our
21 Sep
2023
Institutional seminar
09h-23h
A Circuit Approach to Understand Aging
Uri Alon´s laboratory is focused on several aspects of systems biology, which intersect well with fundamental biological questions addressed by different groups in our unit, and span from investigating gene expression regulation, tissue homeostasis and morphogenesis, network motifs and the design principles of biological circuits. By combining computational biology, mathematical modeling and