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Unit
PIERRE LEOPOLD / YOHANNS BELLAICHE
Genetics and Developmental Biology (UMR3215 / U934)

The research Unit “Genetics and Developmental Biology” of Institut Curie is composed of nine teams addressing fundamental questions related to the development of organisms and its pathological dysfunctions.

Key figures
16
publications in 2020
3
ongoing ERC in 2020
24
PhD Students in 2020
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11 Apr
2024
Institutional seminar "Mayent - Rothschild"
10h-23h
Mechanism of receptor choice in the olfactory system of ants
Bogdan Sieriebriennikov1,2, Hua Yan2 and Claude Desplan1

(1) NYU Biology, New York

(2) University of Florida, Gainesville

In both flies and vertebrates, smell is perceived by olfactory sensory neurons (OSNs) that rely on the expression of a single odorant receptor (Or) gene per cell to discriminate between odors. Flies have few Or genes (~60), while mammals have many (>1,000 in mice),
28 Mar
2024
Seminar
10h-23h
Spatiotemporal models of mammalian development: An epigeneticist’s dream or nightmare?
My research group aims to address the fundamental challenge of understanding how multicellular organisms achieve variation despite cells having identical genetic information. The development of a single fertilized egg into a complete mammalian embryo is an especially beautiful embodiment of this problem. During this process, cellular differentiation is defined by the capacity of the cell ensemble
6 Jul
2023
Institutional seminar
10h-23h
Cellular and environmental mechanisms regulating protein absorption in the vertebrate gut
Intestinal epithelial cells (IECs) are highly polarized and can perform vectorial transport of nutrients using asymmetrically localized membrane proteins and via polarized endocytic and trafficking processes. Using cell biological, forward and reverse genetics, and physiology approaches, we have been investigating mechanisms regulating cell polarization and protein absorption in zebrafish and mice
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