U934/UMR3215 – Genetics and Developmental Biology

The Genetics and Developmental Biology Department (or Unit) of the Institut Curie was inaugurated in October 2008, with the support of CNRS and Inserm and in partnership with University Paris 6 (UPMC). The Unit currently consists of nine internationally competitive research teams.

The goal of this Unit is based on the simple, but fundamental, concept that an understanding of normal developmental regulation should provide us with a better understanding of the basis of human pathology. During development, cells have to integrate different types of molecular and physical information to proliferate, and to make decisions such as whether to maintain pluripotency or trigger differentiation and acquire specialisation for tissue-specific functions.

Cancerisation can result from perturbations at each of these levels and is linked to misregulation of developmental signalling pathways, uncontrolled cellular proliferation and a loss of cellular identity.

Key publications

Year of publication 2019

Julien G Dumortier, Mathieu Le Verge-Serandour, Anna Francesca Tortorelli, Annette Mielke, Ludmilla de Plater, Hervé Turlier, Jean-Léon Maître (2019 Aug 3)

Hydraulic fracturing and active coarsening position the lumen of the mouse blastocyst.

Science (New York, N.Y.) : 465-468 : DOI : 10.1126/science.aaw7709
Bethan Lloyd-Lewis, Philippos Mourikis, Silvia Fre (2019 Jul 20)

Notch signalling: sensor and instructor of the microenvironment to coordinate cell fate and organ morphogenesis.

Current opinion in cell biology : 16-23 : DOI : S0955-0674(18)30179-0
Gervais L, van den Beek M, Josserand M, Sallé J, Stefanutti M, Perdigoto CN, Skorski P, Mazouni K, Marshall OJ, Brand AH, Schweisguth F, Bardin AJ (2019 May 20)

Stem Cell Proliferation Is Kept in Check by the Chromatin Regulators Kismet/CHD7/CHD8 and Trr/MLL3/4

Developmental Cell : DOI : https://doi.org/10.1016/j.devcel.2019.04.033
Laura Boulan*, Ditte Andersen, Julien Colombani, Emilie Boone, Pierre Léopold*, (*corr. authors) (2019 Apr 23)

Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila.

Developmental cell : DOI : 10.1016/j.devcel.2019.03.016
Jamecna D, Polidori DJ, Mesmin B, Dezi M, Lévy D, Bigay J, Antonny B (2019 Mar 22)

An intrinsically disordered region in OSBP acts as an entropic barrier to control protein dynamics and orientation at membrane contact sites

Developmental cell * : * highlighted Trend in Cell Biology 2019 : DOI : 10.1016/j.devcel.2019.02.021
Derya Deveci, Francisco A Martin, Pierre Leopold*, Nuria M Romero*, (*Corr. author) (2019 Feb 26)

AstA Signaling Functions as an Evolutionary Conserved Mechanism Timing Juvenile to Adult Transition.

Current biology : CB : 813-822.e4 : DOI : 10.1016/j.cub.2019.01.053