U934/UMR3215 – Genetics and Developmental Biology

The Genetics and Developmental Biology Department (or Unit) of the Institut Curie was inaugurated in October 2008, with the support of CNRS and Inserm and in partnership with University Paris 6 (UPMC). The Unit currently consists of nine internationally competitive research teams.

The goal of this Unit is based on the simple, but fundamental, concept that an understanding of normal developmental regulation should provide us with a better understanding of the basis of human pathology. During development, cells have to integrate different types of molecular and physical information to proliferate, and to make decisions such as whether to maintain pluripotency or trigger differentiation and acquire specialisation for tissue-specific functions.

Cancerisation can result from perturbations at each of these levels and is linked to misregulation of developmental signalling pathways, uncontrolled cellular proliferation and a loss of cellular identity.

Key publications

Year of publication 2019

Derya Deveci, Francisco A Martin, Pierre Leopold*, Nuria M Romero*, (*Corr. author) (2019 Feb 26)

AstA Signaling Functions as an Evolutionary Conserved Mechanism Timing Juvenile to Adult Transition.

Current biology : CB : 813-822.e4 : DOI : 10.1016/j.cub.2019.01.053
Larissa Mourao, Guillaume Jacquemin, Mathilde Huyghe, Wojciech J Nawrocki, Naoual Menssouri, Nicolas Servant, Silvia Fre (2019 Jan 31)

Lineage tracing of Notch1-expressing cells in intestinal tumours reveals a distinct population of cancer stem cells.

Scientific reports : 888 : DOI : 10.1038/s41598-018-37301-3
Beber A, Taveneau C, Nania M, Tsai FC, Di Cicco A, Bassereau P, Lévy D, Cabral JT, Isambert H, Mangenot S*, Bertin A* (2019 Jan 24)

Membrane reshaping by micrometric curvature sensitive septin filaments

Nature communications : DOI : 10.1038/s41467-019-08344-5

Year of publication 2018

Żylicz Jan Jakub, Bousard Aurélie, Žumer Kristina, Dossin François, Mohammad Eusra, Teixiera da Rocha Simão, Schwalb Björn, Syx Laurène, Dingli Florent, Loew Damarys, Cramer Patrick, Heard Edith (2018 Dec 21)

The Implication of Early Chromatin Changes in X Chromosome Inactivation

Cell : 176 : 1-16 : DOI : 10.1016/j.cell.2018.11.041
Eleonora Meschi, Pierre Léopold*, Renald Delanoue, (*Corr. author) (2018 Dec 10)

An EGF-Responsive Neural Circuit Couples Insulin Secretion with Nutrition in Drosophila.

Developmental cell : DOI : 10.1016/j.devcel.2018.11.029
Anna M Lilja, Veronica Rodilla, Mathilde Huyghe, Edouard Hannezo, Camille Landragin, Olivier Renaud, Olivier Leroy, Steffen Rulands, Benjamin D Simons, Silvia Fre (2018 May 23)

Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland.

Nature cell biology : DOI : 10.1038/s41556-018-0108-1