U934/UMR3215 – Genetics and Developmental Biology

The Genetics and Developmental Biology Department (or Unit) of the Institut Curie was inaugurated in October 2008, with the support of CNRS and Inserm and in partnership with University Paris 6 (UPMC). The Unit currently consists of nine internationally competitive research teams.

The goal of this Unit is based on the simple, but fundamental, concept that an understanding of normal developmental regulation should provide us with a better understanding of the basis of human pathology. During development, cells have to integrate different types of molecular and physical information to proliferate, and to make decisions such as whether to maintain pluripotency or trigger differentiation and acquire specialisation for tissue-specific functions.

Cancerisation can result from perturbations at each of these levels and is linked to misregulation of developmental signalling pathways, uncontrolled cellular proliferation and a loss of cellular identity.

Key publications

Year of publication 2016

Jean-Léon Maître, Hervé Turlier, Rukshala Illukkumbura, Björn Eismann, Ritsuya Niwayama, François Nédélec, Takashi Hiiragi (2016 Aug 4)

Asymmetric division of contractile domains couples cell positioning and fate specification.

Nature : DOI : 10.1038/nature18958
Floris Bosveld, Olga Markova, Boris Guirao, Charlotte Martin, Zhimin Wang, Anaëlle Pierre, Maria Balakireva, Isabelle Gaugue, Anna Ainslie, Nicolas Christophorou, David K. Lubensky, Nicolas Minc & Yohanns Bellaïche (2016 Feb 25)

Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis

Nature : 530 : 495–498 : DOI : 10.1038/nature16970
Timothy W. Dunn, Christoph Gebhardt, Eva A. Naumann, Clemens Riegler, Misha B. Ahrens, Florian Engert, Filippo Del Bene (2016 Feb 3)

Neural Circuits Underlying Visually Evoked Escapes in Larval Zebrafish

Neuron : 89 : 3 : 613-628 : DOI : 10.1016/j.neuron.2015.12.021
Marius Walter, Aurélie Teissandier, Raquel Pérez-Palacios, Déborah Bourc'his (2016 Jan 27)

An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells.

eLife : DOI : 10.7554/eLife.11418

Year of publication 2015

Katarzyna Siudeja, Sonya Nassari, Louis Gervais, Patricia Skorski, Sonia Lameiras, Donato Stolfa, Maria Zande, Virginie Bernard, Thomas Rio Frio, Allison J Bardin (2015 Dec 3)

Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging.

Cell stem cell : 663-74 : DOI : 10.1016/j.stem.2015.09.016
Delphine Gogendeau, Katarzyna Siudeja, Davide Gambarotto, Carole Pennetier, Allison J Bardin, Renata Basto (2015 Nov 17)

Aneuploidy causes premature differentiation of neural and intestinal stem cells.

Nature communications : 8894 : DOI : 10.1038/ncomms9894