U934/UMR3215 – Genetics and Developmental Biology


CALL OPEN FOR GROUP LEADER POSITIONS

until December 1, 2018

Call_for_group_leader_umr3215We are looking for outstanding candidates who will complement the existing strengths of this department in areas including stem cells, tissue growth and morphogenesis, cell polarisation, signal transduction, epigenetics, genomics, and integrated physiology. We encourage research programs that will advance our understanding of normal and cancer development, using variety of animal and cellular models.

Applications should include a CV (with list of publications), a motivation letter, a summary of scientific achievements (1-2 pages), a detailed five-year research plan (5 pages), a one-page summary of research plan, and a contact details of 3-5 individuals who can be contacted for recommendation letters.

Applications should be sent to :

More information ->

 

The Genetics and Developmental Biology Department (or Unit) of the Institut Curie was inaugurated in October 2008, with the support of CNRS and Inserm and in partnership with University Paris 6 (UPMC). The Unit currently consists of nine internationally competitive research teams.

The goal of this Unit is based on the simple, but fundamental, concept that an understanding of normal developmental regulation should provide us with a better understanding of the basis of human pathology. During development, cells have to integrate different types of molecular and physical information to proliferate, and to make decisions such as whether to maintain pluripotency or trigger differentiation and acquire specialisation for tissue-specific functions.

Cancerisation can result from perturbations at each of these levels and is linked to misregulation of developmental signalling pathways, uncontrolled cellular proliferation and a loss of cellular identity.

Key publications

Year of publication 2018

Marlène Rasschaert, Josef A Schroeder, Ting-Di Wu, Sergio Marco, Andréa Emerit, Heiko Siegmund, Claudia Fischer, Nathalie Fretellier, Jean-Marc Idée, Claire Corot, Christoph Brochhausen, Jean-Luc Guerquin-Kern (2018 Jul 10)

Multimodal Imaging Study of Gadolinium Presence in Rat Cerebellum: Differences Between Gd Chelates, Presence in the Virchow-Robin Space, Association With Lipofuscin, and Hypotheses About Distribution Pathway.

Investigative radiology : 53 : 518-528 : DOI : 10.1097/RLI.0000000000000490
Anna M Lilja, Veronica Rodilla, Mathilde Huyghe, Edouard Hannezo, Camille Landragin, Olivier Renaud, Olivier Leroy, Steffen Rulands, Benjamin D Simons, Silvia Fre (2018 May 23)

Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland.

Nature cell biology : DOI : 10.1038/s41556-018-0108-1
Ana Vujic, Carolin Lerchenmüller, Ting-Di Wu, Christelle Guillermier, Charles P Rabolli, Emilia Gonzalez, Samuel E Senyo, Xiaojun Liu, Jean-Luc Guerquin-Kern, Matthew L Steinhauser, Richard T Lee, Anthony Rosenzweig (2018 Apr 27)

Exercise induces new cardiomyocyte generation in the adult mammalian heart.

Nature communications : 9 : 1659 : DOI : 10.1038/s41467-018-04083-1
Trépout S., Tassin A.M., Marco S., Bastin P. (2018 Apr 1)

STEM tomography analysis of the trypanosome transition zone

Journal of Structural Biology : 202 : 51-60 : DOI : 10.1016/j.jsb.2017.12.005
MaryJane Shimell, Xueyang Pan, Francisco A Martin, Arpan C Ghosh, Pierre Leopold, Michael B O'Connor, Nuria M Romero (2018 Feb 23)

Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing.

Development (Cambridge, England) : DOI : dev159699

Year of publication 2017

Slodzian G., Wu T.D., Duprat J., Engrand C., Guerquin-Kern J.L. (2017 Dec 1)

Dynamic transfer applied to secondary ion imaging over large scanned fields with the nanoSIMS 50 at high mass resolution

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms : 412 : 123-173 : DOI : 10.1016/j.nimb.2017.06.019