U934/UMR3215 – Genetics and Developmental Biology

The research Unit “Genetics and Developmental Biology” of Institut Curie is composed of nine teams addressing fundamental questions related to the development of organisms and its pathological dysfunctions.

Our action is based on a simple idea: understanding developmental processes and tissue homeostasis is key to understand the etiology of diseases. We study living organisms at different scales ranging from organisms (mouse, zebrafish, Drosophila) to molecular aspects, and including organoids, patient-derived xenografts and cell lines. This variety of approaches enables an integrated analysis from the cell nucleus to the whole organism.
Our research addresses the following themes:
-the acquisition and maintenance of identity of stem cells, germ cells, or specialized somatic cells through cell signaling and transcriptional control
– the control of gene expression by the non-coding genome (ncRNAs, transposons) in normal and pathological conditions
– the role of mechanical forces and cell divisions in building embryos and tissues
– the role of inter-organ communications and systemic signals in tissue growth and homeostasis.

 

Key publications

Year of publication 2019

Graindorge A, Pinheiro I, Nawrocka A, Mallory AC, Tsvetkov P, Gil N, Carolis C, Buchholz F, Ulitsky I, Heard E, Taipale M, Shkumatava A (2019 Dec 1)

In-Cell Identification and Measurement of RNA-Protein Interactions

Nature Communications
Eric Victor van Leen, Florencia di Pietro, Yohanns Bellaïche (2019 Sep 12)

Oriented cell divisions in epithelia: from force generation to force anisotropy by tension, shape and vertices.

Current opinion in cell biology : 9-16 : DOI : S0955-0674(19)30070-5
Roberta Ragazzini, Raquel Pérez-Palacios, Irem H Baymaz, Seynabou Diop, Katia Ancelin, Dina Zielinski, Audrey Michaud, Maëlle Givelet, Mate Borsos, Setareh Aflaki, Patricia Legoix, Pascal W T C Jansen, Nicolas Servant, Maria-Elena Torres-Padilla, Deborah Bourc'his, Pierre Fouchet, Michiel Vermeulen, Raphaël Margueron (2019 Aug 28)

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.

Nature communications : 3858 : DOI : 10.1038/s41467-019-11800-x
Julien G Dumortier, Mathieu Le Verge-Serandour, Anna Francesca Tortorelli, Annette Mielke, Ludmilla de Plater, Hervé Turlier, Jean-Léon Maître (2019 Aug 3)

Hydraulic fracturing and active coarsening position the lumen of the mouse blastocyst.

Science (New York, N.Y.) : 465-468 : DOI : 10.1126/science.aaw7709
Bethan Lloyd-Lewis, Philippos Mourikis, Silvia Fre (2019 Jul 20)

Notch signalling: sensor and instructor of the microenvironment to coordinate cell fate and organ morphogenesis.

Current opinion in cell biology : 61 : 16-23 : DOI : 10.1016/j.ceb.2019.06.003
Gervais L, van den Beek M, Josserand M, Sallé J, Stefanutti M, Perdigoto CN, Skorski P, Mazouni K, Marshall OJ, Brand AH, Schweisguth F, Bardin AJ (2019 May 20)

Stem Cell Proliferation Is Kept in Check by the Chromatin Regulators Kismet/CHD7/CHD8 and Trr/MLL3/4

Developmental Cell : DOI : https://doi.org/10.1016/j.devcel.2019.04.033