The group of Dr. Sophie Bombard (Biochemistry and Biology of anticancer drugs, http://cmib.curie.fr/en), belonging to the research unit “Chemistry, Modelling and Imaging for Biology”, invites applications for a one-year post-doctoral position to begin September 2019. This position seeks a dynamic and enthusiastic candidate who is interested in elucidating the mechanism of action of promising new metal complexes targeting DNA (including G-quadruplex secondary structures) that have been isolated from an in-house screening for their radiosensitizing properties and in visualizing G-quadruplex-interacting compounds in various cancer cell lines. The prospective postdoctoral fellow will conduct several cellular assays, including cell imaging and ChiP-sequencing, and biochemical assays for in vitro evaluations of the aforementioned compounds. The postdoctoral fellow will also have ample opportunities to collaborate with internationally recognized biologists and chemists at the Institut Curie.
The applicant should have a Ph.D. degree in biochemistry and should be proficient in cell culture and in modern molecular and cellular biology procedures. Experience with DNA repair pathways is a significant plus. A track record (as evidenced by publications in peer-viewed journals) in relevant field is required.
The laboratory is located at the Institut Curie research center at the university campus of Orsay (Université Paris-Saclay – south of Paris, France) and offers a highly competitive scientific infrastructure. Institut Curie is constituted of a hospital and a world-class multidisciplinary research center combining research in cell biology, genetics, epigenetics, immunology, soft matter physics, organic and medicinal chemistry. The institute facilities include advanced imaging, high throughput sequencing, bioinformatics, reverse phase protein array, proteomics and mass spectrometry, antibody technologies, cytometry, and animal housing. Interested candidates please send a CV, a cover letter stating research interests, qualification, and three recommendation letters and references to Dr. Sophie Bombard: firstname.lastname@example.org.