We are looking for motivated and productive post-doctoral fellows (both experimental and computational biologists) to join our ATIP-Avenir team Replication Program and Genome Instability at the Institut Curie, Paris, France. The team focuses on using cutting-edge high-throughput genomic approaches and genome-wide data analyses to study the spatio-temporal replication program of the human genome and its impact on genome stability in normal and cancer cells, in population as well as at single molecule/cell level.
The Institut Curie, located in the heart of Paris, is the largest French cancer research center and one of the world’s leading institutions in the field. It represents an excellent location to perform multidisciplinary research supported by a strong network of the PSL Research University. The project will be performed in close collaboration between our genome analysis team, the bioinformatics/sequencing platforms and the worldwide experimental biologist experts. The candidate will benefit from an excellent multi-disciplinary environment.
Applicant should be a researcher hold, or in the process of completing, a PhD degree in molecular/cell biology, bioinformatics or related areas. The candidate should have solid experimental and/or computational skills and a strong interest in genome biology. Experience with 3th generation sequencing, high-throughput imaging or single cell data analysis is a plus. The candidate should be highly motivated, curious and enthusiastic to work in a collaborative team.
Duration: 1-year renewable, up to 3 years.
Interested candidates should send a detailed CV (education, work/research experience, language skills and other skills relevant for the position, list of publications) along with a cover letter and contact details of 3 referees to C.L. Chen ().
– Brison O*, EL-Hilali S*, et al. Chen CL (2019). Transcription-Mediated Organization of The Replication Initiation Program Across Large Genes Sets Up Common Fragile Sites Genome-Wide. bioRxiv. doi:https://doi.org/10.1101/714717.
– Shi M J, et al. (2019) APOBEC-mediated Mutagenesis as a Likely Cause of FGFR3 S249C Mutation Over-representation in Bladder Cancer. Eur. Urol. 76, 9–13.
– Klein K*. Wang W.* (*co-first authors), et al. (2017) Genome-Wide Identification of Early-Firing Human Replication Origins by Optical Replication Mapping. bioRxiv. doi:https://doi.org/10.1101/214841.
– Petryk N, et al., Chen CL* and Hyrien O* (*co-last authors). (2016) Replication landscape of the human genome. Nat. Commun. 7:10208.
– Van Dijk EL*, Chen CL* (co-first authors), et al. (2011) XUT, a novel class of antisense regulatory ncRNA in yeast. Nature 475:114-7.