Among 47 retained projects for the call « FRM teams 2016 », three institut Curie projects have been selected.
Stem Cells and Tissue Homeostasis (Institut Curie / UMR 3215 CNRS / U934 Inserm), managed by Allison Bardin (CNRS research Director)
Stem cells are characterized by their ability to self-renew as well as to produce differentiated progeny. The group identifies mechanisms important for these processes and ultimately to understand how they function collectively to promote homeostasis of a tissue.
DNA Recombination, Replication and Genome Stability (Institut Curie / UMR 3348 CNRS), managed by Sarah Lambert (CNRS research Director)
The causes of replication stress are many and varied, but they ultimately affect the progression of replication forks and can jeopardize the even segregation of chromosome in mitosis. The aim of our research is to decipher the molecular transactions occurring at replication forks in response to replication stress and to understand how these mechanisms trigger genome instability.
Germ Cell Development (Institut Curie / UMR 3215 CNRS / U934 Inserm), managed by Jean René Huynh (CNRS research Director)
Team addresses the following questions:
- How is germline stem cell growth regulated? GSCs divide actively and need to recover their initial volume/mass quickly after each division. We found that specialized mechanisms are involved.
- How is the duration of cytokinesis regulated in germ cells? We identified mutations in Drosophila Aurora-B and Cyclin-B genes, which regulate complete abscission in germline stem cells and incomplete abscission in differentiating germ cells.
- How do homologue chromosomes find each other during meiosis? We are studying the potential role of the cytoplasmic cytoskeleton in regulating chromosome organization during the early steps of meiosis in the germarium.
- How is the germline genetic material protected from DNA damages? The genetic information contained in the female gamete needs to be safely transmitted to the next generation. We are studying how mobile DNA elements such as transposons are silenced in germline cells.
Image © Institut Curie, from left to right: Jean René Huynh, Sarah Lambert, Allison Bardin