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Mechanisms generating rapid genome evolution

Invited by Geneviveve Almouzni, Prof. David Pellman, Pediactric Oncology – Cell Biology researcher at Dana-Farber Cancer Institute, gave a talk at Institut Curie.

Genomic alterations have traditionally been thought of as a classic Darwinian process of gradual mutational accrual.  However, recent work from us and others has defined mechanisms driving rapid genome evolution due to catastrophic cell division errors.  I will describe recent progress on these processes, which include chromothripsis and chromosome breakage-fusion-bridge cycles.